| Coherent Data Analytics Ltd | Information & communication | 2015 |
| Colabs Innovations Ltd | Manufacturing | 2025 |
| Colextoo Ltd | Health & social care | 2021 |
| Coley Properties (2018) Limited | Real estate | 2023 |
| College Gardens Management (NO 1) Limited | Households | 1990 |
| College Gardens Management (NO 3) Limited | Households | 1991 |
| College View Property Rentals Ltd | Real estate | 2025 |
| Collingwood Property Management Limited | Real estate | 2025 |
| Color Agri Groupe Limited | Construction | 2026 |
| Combat Investments Ltd | Real estate | 2025 |
| Combat Sports Nutrition Ltd | Education | 2024 |
| Comerest Ltd | Real estate | 2022 |
| Comic Market UK Ltd | Wholesale & retail | 2026 |
| Commercial and Industrial Services (Manchester) Limited | Information & communication | 1969 |
| Comms Save Group Limited | Extraterritorial | 2009 |
| Community and Voluntary Services Cheshire East | Other services | 2009 |
| Community LED Services Limited | Real estate | 2015 |
| Community Recycle Cycles CIC | Wholesale & retail | 2012 |
| Como Health Care Ltd | Public administration | 2020 |
| Companion Business Group Ltd | Financial services | 2026 |
| Compare Biomarket Ltd | Professional & scientific | 2017 |
| Compassionate Estates Limited | Real estate | 2021 |
| Compassionate Healthcare Limited | Health & social care | 2015 |
| Compassionate Nursing Solutions Ltd | Health & social care | 2025 |
| Compitsystems Ltd | Information & communication | 2010 |
| Complementary Birth Ltd | Education | 2013 |
| Complete Homes (Cheshire) Limited | Construction | 2007 |
| Complete Wills (Storage) Limited | Professional & scientific | 2021 |
| Complete Wills Estate Planning Services Limited | Professional & scientific | 2008 |
| Completech Limited | Professional & scientific | 1986 |
| COMPONENTS4ALL Limited | Wholesale & retail | 2007 |
| Concept Commercial Finance Limited | Financial services | 2018 |
| Concorde (NO.1) Ltd | Construction | 2018 |
| Confederation of Fibre Optic and Network Infrastructure Installers Ltd | Other services | 2025 |
| Conflux Consultants Limited | Information & communication | 1998 |
| Connect in Cheshire Ltd | Administrative & support | 2019 |
| Connective Infrastructure Ltd | Professional & scientific | 2025 |
| Conquer Fitness Events Limited | Arts & recreation | 2024 |
| Constable Tower Management Limited | Hospitality | 1994 |
| Construction Linx (Holdings) Limited | Administrative & support | 2010 |
| Construction Linx Limited | Construction | 2005 |
| Construction Material Recycling Limited | Other services | 1996 |
| Contact Photographic Services Limited | Manufacturing | 1985 |
| Continuum Info Tech Limited | Wholesale & retail | 2025 |
| Contract Management Solutions (CMS) Limited | Professional & scientific | 2015 |
| Contractor & Co Design Limited | Professional & scientific | 2026 |
| Convergent Engineering Design Ltd. | Professional & scientific | 2011 |
| Conwy & Denbighshire Care Limited | Financial services | 2026 |
| Cooke Building Ltd | Construction | 2025 |
| Cooler Options Limited | Water & waste | 2014 |
| Cooloo Investment Company | Financial services | 2024 |
| Coombe UK Holdings Limited | Wholesale & retail | 2025 |
| Cooper Buckley Limited | Transport & logistics | 1964 |
| Cooper Capital Ltd | Real estate | 2021 |
| Coorstek Advanced Materials Crewe Limited | Manufacturing | 1992 |
| Coppenhall Pharmacy Ltd | Wholesale & retail | 2019 |
| Corbett Roofing & Guttering Ltd | Construction | 2023 |
| Core Fit Unique Limited | Other services | 2015 |
| Core Fulfilment Limited | Transport & logistics | 1997 |
| Core Medical Group Ltd | Wholesale & retail | 2020 |
| Corepoint Consulting Limited | Professional & scientific | 2025 |
| Cores. Limited | Construction | 2007 |
| Cornerstone Alternative Education Ltd | Education | 2020 |
| Cosareanu Driver Ltd | Transport & logistics | 2023 |
| Costatour Ltd | Transport & logistics | 2019 |
| Costyb Trans Ltd | Transport & logistics | 2017 |
| Cosworth Enterprises Ltd | | 1992 |
| Cosy Home Rentals Limited | Real estate | 2020 |
| Cotton Hall Ltd | Agriculture & fishing | 2025 |
| Cottons DDC Ltd | Agriculture & fishing | 2025 |
| County Brides and Events Limited | Information & communication | 2016 |
| County Brides Limited | Information & communication | 2017 |
| Coverdrone Limited | Financial services | 2015 |
| Cowap Mobile Welding Services Limited | Construction | 2012 |
| Cowap Rail Services Limited | Construction | 2019 |
| Cozy Alley Properties Ltd | Real estate | 2024 |
| CP Building and Joinery Limited | Construction | 2019 |
| Crafts of Cheshire Ltd | Wholesale & retail | 2023 |
| Craftwerk Bars & Restaurants Ltd | Hospitality | 2022 |
| Craftwerk Beers Ltd | Hospitality | 2018 |
| Craftwerk Trading Ltd | Hospitality | 2023 |
| Craig Dixon Limited | Transport & logistics | 2017 |
| Cranage Hall Farm Management Limited | Real estate | 2004 |
| CRC Trans 2025 Ltd | Transport & logistics | 2025 |
| CRD Telecom Ltd | Construction | 2025 |
| CRE8TIVE Link Limited | Administrative & support | 2003 |
| Creation Capital Group Limited | Financial services | 2026 |
| Creation Furniture Group Limited | Wholesale & retail | 2021 |
| Creative Action Team C.I.C. | Health & social care | 2013 |
| Creative Card Crewe Limited | Wholesale & retail | 2013 |
| Crewe Accountants Ltd | Professional & scientific | 2016 |
| Crewe Alexandra Football Club Company,Limited(The) | Arts & recreation | 1899 |
| Crewe Alexandra Group Limited | Professional & scientific | 2019 |
| Crewe Alexandra in the Community Limited | Arts & recreation | 2005 |
| Crewe Asian Store Limited | Wholesale & retail | 2021 |
| Crewe Bargains Ltd | Wholesale & retail | 2026 |
| Crewe Butcher Ltd | Wholesale & retail | 2025 |
| Crewe Central Table Tennis Club C.I.C. | Arts & recreation | 2022 |
| Crewe Construction Services Limited | Construction | 2005 |
| Crewe Delivery Ltd | Transport & logistics | 2020 |