| Sabi Ltd | Wholesale & retail | 2019 |
| Sabre Education Limited | Education | 2004 |
| Sabti Ltd | Wholesale & retail | 2019 |
| Sacul Investments Limited | Financial services | 2020 |
| Saeed Sobo Technologies Limited | Wholesale & retail | 2025 |
| Saeso Couriers Limited | Transport & logistics | 2025 |
| Safa Essence Ltd | Wholesale & retail | 2023 |
| Saferide Gatwick Ltd | Transport & logistics | 2023 |
| Saferoute Transfer Ltd | Transport & logistics | 2025 |
| Safeway Cars Crawley Ltd | Transport & logistics | 2024 |
| Safeway Cleaning Limited | Administrative & support | 2018 |
| Saffie’S Collection Ltd | Wholesale & retail | 2024 |
| Saffron Caterers Limited | Hospitality | 2018 |
| Sahara Bar Cafe Ltd | Hospitality | 2024 |
| SAI VAS Limited | Information & communication | 2023 |
| SAJ European Limited | Transport & logistics | 2024 |
| SAJ Management Services Limited | Wholesale & retail | 2011 |
| SAJ Portfolios Ltd | Real estate | 2022 |
| Sajina Ltd | Real estate | 2024 |
| SAK Europe Ltd | Construction | 2017 |
| SAK Eyecare Ltd | Health & social care | 2025 |
| SAK UK Marketing Ltd | Professional & scientific | 2019 |
| Sakt Ltd | Hospitality | 2020 |
| SAL Gate Security Services Ltd | Administrative & support | 2024 |
| Salama Foods Limited | Hospitality | 2019 |
| Salazar Health Care Limited | Health & social care | 2015 |
| Sale and Deal UK Ltd | Wholesale & retail | 2026 |
| Sale Holdings Limited | Financial services | 2024 |
| Saleeth Holdings Ltd | Wholesale & retail | 2025 |
| Salomir Holdings Limited | Financial services | 2024 |
| Salontwelve Limited | Administrative & support | 2012 |
| SAM UK Enterprises Ltd | Wholesale & retail | 2026 |
| Sam's Tech Limited | Wholesale & retail | 2025 |
| Samatvam Limited | Professional & scientific | 2019 |
| Same Day Solutions - SDS Ltd | Other services | 2020 |
| Sammy & Co Tax Associate Ltd | Professional & scientific | 2015 |
| Sammy & Jessy Limited | Health & social care | 2024 |
| Samosa Singh Enterprise Ltd | Information & communication | 2022 |
| Sampa Sydney Limited | Health & social care | 2017 |
| Samuel Storey Evans Ltd | Wholesale & retail | 2022 |
| Samy Housing Limited | Real estate | 2020 |
| Samyrkhan Ltd | Health & social care | 2024 |
| Sanctuary Holidays Limited | Administrative & support | 2008 |
| Sanderana Limited | Professional & scientific | 2021 |
| Sandhill Farm Limited | Agriculture & fishing | 2014 |
| Sandhu Contracting Ltd | Transport & logistics | 2019 |
| Sandwich Square Ltd | Other services | 2025 |
| Sanitaire Ltd | Hospitality | 2021 |
| Santok Homes Limited | Real estate | 2025 |
| Santos Neto & Roga Promotions Ltd | Administrative & support | 2018 |
| Sapphire Parking Limited | Transport & logistics | 2026 |
| Sapphire Smiles Ltd | Health & social care | 2024 |
| Sapphire Solicitors & Advocates Ltd. | Professional & scientific | 2024 |
| Sapphire Tiles Ltd | Wholesale & retail | 2014 |
| Saracen Group Ventures Ltd | Information & communication | 2016 |
| Sarah Meers LPA Limited | Professional & scientific | 2026 |
| Sarah Verey Studio Ltd | Construction | 2020 |
| Saranjha & Co Ltd | Wholesale & retail | 2025 |
| Sargacycle Ltd | Mining & quarrying | 2025 |
| Sari Restaurant Ltd | Hospitality | 2023 |
| Sarkisian Films Ltd | Information & communication | 2024 |
| Sarrf Interior Ltd | Wholesale & retail | 2023 |
| Sarumdale Limited | Hospitality | 1990 |
| Sastra Consulting Ltd | Information & communication | 2018 |
| Sattva Consultancy Ltd | Construction | 2026 |
| Sauber Group Ltd | Administrative & support | 2024 |
| Savings Seeker Ltd | Wholesale & retail | 2025 |
| Savira Enterprise Technologies Limited | Other services | 2012 |
| Savour Station Ltd | Manufacturing | 2025 |
| Savu Services Ltd | Construction | 2018 |
| Sawyer Coachworks Limited | Wholesale & retail | 2014 |
| Saxonbrook Services Ltd | Health & social care | 2018 |
| Saxongate Publishing Limited | Information & communication | 2016 |
| Saxony Carpets Ltd | Construction | 2022 |
| Sayan Linguistics Ltd | Other services | 2015 |
| Sayers Publishing Group Limited | Information & communication | 1988 |
| SB Compliance Consultancy Ltd | Professional & scientific | 2025 |
| SB Crawley Ltd | Hospitality | 2025 |
| Sbsfood Ltd | Hospitality | 2025 |
| SC Plant and Commercials UK Ltd | Wholesale & retail | 2026 |
| Scaffold Accessories & Supplies Ltd | Wholesale & retail | 2021 |
| Scaffolding Products Ltd | Manufacturing | 2013 |
| Scampers Petcare Superstore Limited | Wholesale & retail | 1991 |
| SCB Property Management Ltd | Real estate | 2021 |
| Scento Ltd | Construction | 2019 |
| Schlumberger Cambridge Research Limited | Administrative & support | 1958 |
| Schlumberger Common Investment Fund Limited | Financial services | 2002 |
| Schlumberger Oilfield UK Limited | Professional & scientific | 2001 |
| Schlumberger Trust Company Limited | Financial services | 1988 |
| Schlumberger UK Holdings Limited | Professional & scientific | 1982 |
| Schlumberger UK Limited | Professional & scientific | 2010 |
| School of Sleep Ltd | Professional & scientific | 2024 |
| Sciara Limited | Real estate | 2019 |
| Scintilla Care Services Limited | Health & social care | 2022 |
| SCL Support Limited | Education | 2021 |
| SCL Technology Limited | Manufacturing | 2018 |
| Scobie Asset Finance Limited | Administrative & support | 2012 |
| Scobie Bakery Services Limited | Administrative & support | 2020 |
| Scobie Catering Services Limited | Administrative & support | 2020 |
| Scobie Coffee Services Limited | Manufacturing | 2020 |