| Scobie Equipment Limited | Manufacturing | 2016 |
| Scobie Group Limited | Financial services | 2020 |
| Scobie Maintenance Limited | Construction | 2005 |
| Scobie Mcintosh Group Limited | Financial services | 2020 |
| Scobie Mcintosh Logistics Limited | Transport & logistics | 2020 |
| Scobie Projects Limited | Manufacturing | 2016 |
| Scobie Refrigeration Limited | Manufacturing | 2020 |
| Scobie Technical Services Limited | Manufacturing | 2020 |
| Scobie Vending Services Limited | Administrative & support | 2020 |
| Scobles Rigging Ltd | Construction | 2017 |
| Scoobie Burger Van Limited | Hospitality | 2023 |
| Scope Ophthalmics Limited | Wholesale & retail | 2011 |
| Scorpion Trading Ltd | Financial services | 2009 |
| Scotty’S Automotive Ltd | Construction | 2026 |
| SCP (UK) Holdings Limited | Professional & scientific | 1998 |
| SCP (UK) Limited | Wholesale & retail | 1966 |
| Scratched UP Records Ltd | Information & communication | 2024 |
| Scratchmark Ltd | Information & communication | 2016 |
| Scrooged Ltd | Professional & scientific | 2010 |
| Scymaxx Cleaning Services Limited | Administrative & support | 2025 |
| SDR Aerospace Limited | Transport & logistics | 2013 |
| SE HR Consultancy Ltd | Professional & scientific | 2023 |
| Sea at Dawn Limited | Information & communication | 2022 |
| Sea Watch Foundation - the Cetacean Monitoring Unit | Professional & scientific | 1991 |
| Seabre Solutions Limited | Information & communication | 2022 |
| Seacap Trans Ltd | Transport & logistics | 2022 |
| Seager Property Ventures Limited | Financial services | 2025 |
| Sean Bennett Electrical Limited | Construction | 2018 |
| Seawing OIL and GAS Company Limited | Extraterritorial | 2024 |
| Sebel Investments Limited | Construction | 2020 |
| Second Call Limited | Financial services | 2013 |
| Second to MUM Ltd | Health & social care | 2026 |
| Secure 24 Support Ltd | Transport & logistics | 2023 |
| Secure Logiq Limited | Manufacturing | 2011 |
| Securicom Ltd | Administrative & support | 2019 |
| Security & Visual Installations Ltd | Construction | 2026 |
| Security Partners International Limited | Administrative & support | 2007 |
| SEE Electrical Ltd | Construction | 2026 |
| Sefiso Limited | Transport & logistics | 2024 |
| SEH Capital Ltd | Real estate | 2024 |
| Select Fashion Ltd | Wholesale & retail | 2019 |
| Selecttvformats Ltd | Information & communication | 2018 |
| Selfies Selfies Ltd | Hospitality | 2019 |
| Selfless Care Ltd | Health & social care | 2025 |
| Selsey Properties Ltd | Real estate | 2024 |
| Semi Retired Ltd | Information & communication | 2025 |
| Semicolon Software Services Ltd | Information & communication | 2026 |
| Sens-Air Limited | Manufacturing | 1984 |
| SENSE6 Pet Food Limited | Manufacturing | 2019 |
| Sentinalcore Limited | Information & communication | 2025 |
| Sentro Ltd | Extraterritorial | 2024 |
| Sepril Lodge Limited | Households | 1987 |
| Serenity Holdings Ltd | Financial services | 2024 |
| Serenity Homes Group Ltd | Real estate | 2023 |
| Serenity School Crawley Ltd | Education | 2022 |
| Serious Biscuit Ltd | Information & communication | 2018 |
| Serosep UK Limited | Professional & scientific | 2012 |
| Servaops Ltd | Administrative & support | 2025 |
| Service Hands Limited | Administrative & support | 2023 |
| Service Technologies Limited | Information & communication | 2017 |
| Service Vent Ltd | Construction | 2010 |
| Settled Aparthotel Ltd | Hospitality | 2025 |
| Seylan Cars Limited | Transport & logistics | 2024 |
| Seymour Cutting Solutions Limited | Administrative & support | 2020 |
| SF Collection Ltd | Wholesale & retail | 2026 |
| SF Global Services Ltd | Manufacturing | 2023 |
| SF Medipharma Limited | Professional & scientific | 2026 |
| SFR Co-Living Limited | Transport & logistics | 2025 |
| SFX Consulting Limited | Administrative & support | 2017 |
| SGG Courier Ltd | Transport & logistics | 2024 |
| SH Prestige Cosmetic Ltd | Other services | 2014 |
| Shabskr Solutins Limited | Wholesale & retail | 2025 |
| Shaft Solutions Ltd | Construction | 2025 |
| Shahid Samia Limited | Health & social care | 2013 |
| Shahra Clothing Limited | Wholesale & retail | 2022 |
| Shai Solutions Ltd | Professional & scientific | 2025 |
| Shailesh Engineering Services Ltd | Professional & scientific | 2012 |
| Shaka Capital Limited | Professional & scientific | 2024 |
| Shalerose Properties Limited | Real estate | 2001 |
| Shalom Childcare Ltd | Other services | 2012 |
| Shalom Elohim Ltd | Wholesale & retail | 2025 |
| Shaolin TAI CHI Kung FU Academy Ltd | Arts & recreation | 2012 |
| Shareplan Limited | Administrative & support | 2002 |
| Sharma's Pubs & Restaurants Ltd | Hospitality | 2020 |
| Sharmilaa Holdings UK Limited | Real estate | 2020 |
| Sharon Syndic Jewelry Ltd | Wholesale & retail | 2021 |
| Sharp Eco Ltd | Administrative & support | 2022 |
| Sheikh Renovations Ltd | Construction | 2024 |
| Sheikho Ltd | Wholesale & retail | 2025 |
| Shema Consultancy Limited | Health & social care | 2010 |
| Shepherds Construction Ltd | Construction | 2025 |
| Sheq Certification Ltd | Professional & scientific | 2019 |
| Sherlock & Sherlock Ltd | Extraterritorial | 2020 |
| Shetland Car Auto Motion Ltd | Administrative & support | 2024 |
| SHI Black Shilajit Ltd | Wholesale & retail | 2025 |
| Shila Digital Ltd | Information & communication | 2022 |
| Shillan Property Ltd | Real estate | 2020 |
| Shiloh Ciel Co Ltd | Real estate | 2023 |
| Shine Brighter Ltd | Administrative & support | 2025 |
| Shinerock Properties Limited | Construction | 2003 |