| Samnc Limited | Real estate | 2023 |
| Sandbach Hydraulics Ltd | Manufacturing | 2014 |
| Sandbach Milk Ltd | Wholesale & retail | 2021 |
| Sandhole Oak Barn Limited | Real estate | 2024 |
| Sandtrion Limited | Administrative & support | 2020 |
| Sanzion Limited | Wholesale & retail | 2019 |
| Sarah Cope Enterprises Limited | Wholesale & retail | 2017 |
| Sarah-Jane Mcintosh Limited | Administrative & support | 2001 |
| Sarks (UK) Limited | Professional & scientific | 2011 |
| Savill & SON Removals Ltd | Transport & logistics | 2020 |
| SB Car Sales (NW) Ltd | Wholesale & retail | 2023 |
| Science Webinars Limited | Education | 2022 |
| Scissor Wood Limited | Manufacturing | 2008 |
| SCL Property Management Limited | Households | 2021 |
| Scope Electrics Limited | Financial services | 2019 |
| Scorpus Ltd. | Wholesale & retail | 2022 |
| Scotney Cooper Properties Ltd | Real estate | 2025 |
| Scotts Engineering Ltd | Professional & scientific | 2023 |
| Scotty's Shake Shed LLP | | 2025 |
| SCP Aesthetics Ltd | Health & social care | 2022 |
| Scribere Limited | Professional & scientific | 2012 |
| SD Finance and Accountancy Limited | Professional & scientific | 2024 |
| SDG Electrical Testing Ltd | Professional & scientific | 2026 |
| Sea View Villa Limited | Professional & scientific | 2009 |
| Seafox Court (Sherburn) Management Company Limited | Real estate | 2013 |
| Seaside Spain Limited | Professional & scientific | 2018 |
| SECUR-80 Keyholding Limited | Administrative & support | 2023 |
| SECUR-80 Limited | Administrative & support | 2015 |
| Select Food Service Ltd | Wholesale & retail | 2016 |
| Sensa Hair and Wellness Ltd | Wholesale & retail | 2025 |
| Sensiball Limited | Other services | 2007 |
| SEO Stoke Limited | Information & communication | 2017 |
| Serenidad Limited | Professional & scientific | 2017 |
| Serenity Alley Ltd | Health & social care | 2024 |
| Serenity Designs (Congleton) Limited | Wholesale & retail | 2018 |
| Sevenoaks Projects Ltd | Information & communication | 2025 |
| Sfinks Limited | Professional & scientific | 2011 |
| SG Parade Property Limited | Health & social care | 2022 |
| SGR Enterprises Limited | Financial services | 2014 |
| Shamrock K9 Ltd | Administrative & support | 2018 |
| Sharma Limited | Extraterritorial | 2004 |
| Shellow Lane Lodges Ltd | Hospitality | 2015 |
| Shhh Beauty and Aesthetics Ltd | Other services | 2016 |
| Shield Self Storage Limited | Administrative & support | 2022 |
| Shires Memorial Services Limited | Real estate | 2022 |
| Shobna Gulati Ltd | Administrative & support | 2005 |
| Shocklach Limited | Professional & scientific | 2010 |
| Shropshire Raft Tours Ltd | Administrative & support | 2014 |
| Siam Property Limited | Construction | 2014 |
| SIB Developments Ltd | Construction | 2014 |
| Siesta Property Limited | Professional & scientific | 2009 |
| Siesta Sun Limited | Professional & scientific | 2019 |
| Sifted Payroll Ltd | Administrative & support | 2021 |
| Sifted Recruitment Ltd | Administrative & support | 2021 |
| Sigora Insights Ltd | Information & communication | 2026 |
| Silkali Limited | Wholesale & retail | 2015 |
| Silpin Limited | Professional & scientific | 2012 |
| Silverstar PA Care Ltd | Health & social care | 2025 |
| Silverstone Home Enhancements Limited | Construction | 2017 |
| SIM Vehicle Solutions Ltd. | Extraterritorial | 2023 |
| Simple System North Mids Ltd | Transport & logistics | 2022 |
| Simply Beams Limited | Professional & scientific | 2019 |
| Singularity Finance Limited | Financial services | 2025 |
| Siren Water Hygiene Limited | Water & waste | 2025 |
| Sisu Express Limited | Transport & logistics | 2018 |
| Sisu Logistics (UK) Ltd | Transport & logistics | 2020 |
| Site Stack Ltd | Information & communication | 2026 |
| Sitetex Ltd | Arts & recreation | 2023 |
| SJ Cleaning Services Macclesfield Limited | Administrative & support | 2022 |
| SJO Projects Ltd | Professional & scientific | 2025 |
| SK Scaffolding 2017 Ltd | Construction | 2019 |
| Skob Ltd | Real estate | 2023 |
| Skulptoria Ltd | Wholesale & retail | 2024 |
| Sky Blue Desk Ltd | Professional & scientific | 2018 |
| Slambo Limited | Professional & scientific | 2011 |
| SLD Plastering Ltd | Construction | 2023 |
| Slingshot Marketing Limited | Professional & scientific | 2023 |
| SLW Enterprise Ltd | Professional & scientific | 2015 |
| Smada Developments Limited | Real estate | 2023 |
| Small Brook Garden Products Ltd | Administrative & support | 2015 |
| Smart E FD Limited | Professional & scientific | 2021 |
| Smart Nation Limited | Professional & scientific | 2021 |
| Smart Sales Consulting Ltd | Professional & scientific | 2016 |
| Smart Touch Auto Care Ltd | Wholesale & retail | 2024 |
| Smartblinds Limited | Professional & scientific | 2008 |
| Smarter Energy Choices Ltd | Construction | 2024 |
| Smartly Balanced Limited | Professional & scientific | 2019 |
| SMD Aviation Ltd | Manufacturing | 2024 |
| Smds Solution Holdings Ltd | Professional & scientific | 2007 |
| SME Bookkeeping & Accountancy Ltd | Professional & scientific | 2017 |
| SMI Property Ltd | Real estate | 2023 |
| Smooth Parcel Limited | Other services | 2020 |
| SN Skincare & Aesthetics Ltd | Health & social care | 2023 |
| Snaptup Limited | Professional & scientific | 2012 |
| Snarge Ltd | Manufacturing | 2021 |
| Snelson Investments Limited | Financial services | 2019 |
| Snelson Property Services Limited | Manufacturing | 2009 |
| Snorom Limited | Professional & scientific | 2014 |
| Snowball Advisory Limited | Financial services | 2018 |
| Snowball Alternative Finance Limited | Financial services | 2017 |