| Snowball Consulting Ltd | Professional & scientific | 2010 |
| Snowball Group Limited | Financial services | 2018 |
| Snowball Strategic Growth Limited | Professional & scientific | 2018 |
| Snubem Limited | Professional & scientific | 2013 |
| SO Much More Than Accounts Limited | Administrative & support | 2020 |
| Soapy Joe's Valeting Centre Limited | Other services | 2019 |
| Social FLO Ltd | Professional & scientific | 2024 |
| Sojam Investments Ltd | Administrative & support | 2012 |
| SOL Property Limited | Professional & scientific | 2009 |
| Sola Gratia Solutions Ltd | Health & social care | 2023 |
| Solcaliente Limited | Professional & scientific | 2018 |
| Soleado Limited | Professional & scientific | 2017 |
| Solearm Limited | Professional & scientific | 2009 |
| Solisto Limited | Professional & scientific | 2011 |
| Solt Creative Ltd | Other services | 2022 |
| Solution Mortgages Limited | Financial services | 1981 |
| Somerford Park Farm Limited | Agriculture & fishing | 2018 |
| Somerset Storage Installations (UK) Ltd | Construction | 2023 |
| Sophie ANN Solutions Limited | Transport & logistics | 2006 |
| Sophie Moores School of Dance Limited | Arts & recreation | 2025 |
| Sorrel Housing Consultants Ltd | Professional & scientific | 2020 |
| SOS Bphc Ltd. | Financial services | 2011 |
| SP Digital Media Production Ltd | Information & communication | 2024 |
| SP Painting Limited | Construction | 2025 |
| Spaggle Limited | Professional & scientific | 2017 |
| Spall Clark Solicitors Limited | Professional & scientific | 2019 |
| Spanaway Limited | Professional & scientific | 2011 |
| Spanish Location Limited | Professional & scientific | 2009 |
| Spanish Paradise Limited | Professional & scientific | 2019 |
| Spanish Views Limited | Real estate | 2009 |
| Sparklex Racing Limited | Arts & recreation | 2013 |
| Spartisan Ltd | Manufacturing | 2012 |
| Spdb Limited | Construction | 2006 |
| Specialised Aluminium Supplies Limited | Manufacturing | 2001 |
| Specialist Automotive and Supercars Limited | Extraterritorial | 2010 |
| Specialist Soccer Ltd | Arts & recreation | 2013 |
| Spectacle Socks Ltd | Wholesale & retail | 2026 |
| Spice Fusion (Congleton) Ltd | Hospitality | 2026 |
| Spice Merchant (Leek) Ltd | Hospitality | 2021 |
| SPICE4DRINK Ltd | Manufacturing | 2014 |
| Spillane & Associates Limited | Professional & scientific | 2015 |
| Spja Limited | Professional & scientific | 2026 |
| Sports Lottery Limited | Arts & recreation | 2012 |
| Spotlight Brand Placement Limited | Professional & scientific | 2004 |
| Spotty Lottie Limited | Real estate | 2022 |
| Spring Grove-Road Management Company Limited | Households | 2006 |
| Squeeky Cleaners Limited | Administrative & support | 2025 |
| SRI Water Engineering Limited | Administrative & support | 2005 |
| SSC Property Management Ltd | Real estate | 2023 |
| SSL101 Limited | Construction | 2023 |
| SSL103 Limited | Construction | 2023 |
| SSL104 Limited | Construction | 2023 |
| SSL105 Limited | Construction | 2023 |
| SSL106 Limited | Construction | 2023 |
| SSL107 Limited | Construction | 2023 |
| Stables Direct Ltd | Wholesale & retail | 2012 |
| Stakkah Ltd | Real estate | 2025 |
| Stal (UK) Limited | Construction | 2010 |
| Stanley PR Limited | Professional & scientific | 2014 |
| Stanley's Electrical Contractors Limited | Construction | 2022 |
| Starboyclub Ltd | Wholesale & retail | 2025 |
| Starseed Sisterhood Ltd | Wholesale & retail | 2024 |
| STD Developments Limited | Transport & logistics | 1991 |
| Steadbarn Limited | Households | 1999 |
| Steel Laced Limited | Manufacturing | 2019 |
| Stem to Stern Limited | Manufacturing | 2014 |
| Stephenson Browne Limited | Real estate | 2010 |
| Sterling Accountancy Services (Cheshire) Ltd | Professional & scientific | 2019 |
| Sterling Green Financial Ltd | Administrative & support | 2016 |
| Sterling Green Limited | Financial services | 2005 |
| Sterling Investment Properties Limited | Real estate | 2016 |
| Steve Walton Ltd | Construction | 2022 |
| Steve Walton Property Ltd | Real estate | 2023 |
| Sticker Printers Ltd | Manufacturing | 2025 |
| Stock Bar Limited | Hospitality | 2010 |
| Stone Hammer Music Ltd | Education | 2019 |
| Stonehammer Sales and Repairs Ltd | Manufacturing | 2021 |
| Storm Cutting Formes Ltd | Financial services | 2015 |
| Storm Tool & DIE (UK) Ltd | Manufacturing | 2015 |
| Stormguard Floodplan Limited | Manufacturing | 2013 |
| Stormguard Limited | Manufacturing | 2001 |
| Stormguard Sills Limited | Extraterritorial | 2001 |
| Stradling Brothers Ltd | Construction | 2024 |
| Stradling Developments Limited | Construction | 2024 |
| Strategia Consult Ltd | Professional & scientific | 2015 |
| Street Adderley Limited | Real estate | 1999 |
| Streetgym Limited | Arts & recreation | 2011 |
| Stressheads & Overthinkers Ltd | Health & social care | 2026 |
| Studio Jubilee Associates Limited | Professional & scientific | 2018 |
| Stumpling Limited | Professional & scientific | 2013 |
| SUBCO2 Ltd | Other services | 2010 |
| Subjecta Limited | Administrative & support | 2001 |
| Sudnik Software Ltd | Information & communication | 2024 |
| Sueno Property Limited | Professional & scientific | 2010 |
| Sugar Party Ltd | Wholesale & retail | 2026 |
| Sula Group Ltd | Financial services | 2026 |
| Sulaco Aviation Services Ltd | Manufacturing | 2022 |
| Sulu Makers Ltd | Manufacturing | 2022 |
| Summit Commercial Finance Ltd | Financial services | 2025 |
| Sumo Monkey Development Ltd | Information & communication | 2014 |