| Soaring Worldwide Limited | Other services | 2006 |
| Social Partnerships Limited | Professional & scientific | 2001 |
| Socomec U.K. Limited | Information & communication | 1986 |
| Sodra Wood Limited | Wholesale & retail | 1984 |
| Softener Salts Limited | Wholesale & retail | 2017 |
| Soks Racing Ltd | Arts & recreation | 2025 |
| SOL Ride Europe Ltd | Wholesale & retail | 2019 |
| Solapac Ltd | Manufacturing | 2012 |
| Solar Butter Limited | Construction | 2026 |
| Solo Law Ltd | Professional & scientific | 2022 |
| Sonoma Health Ltd | Health & social care | 2023 |
| Sophie Harris-Taylor Ltd | Professional & scientific | 2023 |
| Sophie Ryder Ltd | Arts & recreation | 2016 |
| Souley Spares Limited | Wholesale & retail | 2021 |
| Sound OUT Consulting Ltd | Professional & scientific | 2011 |
| Source Conscience Ltd | Professional & scientific | 2019 |
| South Cerney Developments Limited | Financial services | 2014 |
| South Cerney Golf Course Limited | Arts & recreation | 2000 |
| South Cerney Sailing Club Limited | Hospitality | 1966 |
| South Farm Products Limited | Agriculture & fishing | 1964 |
| Southby & Co Financial Planning Ltd | Administrative & support | 2023 |
| Southern Right Capital Partners Limited | Financial services | 2015 |
| Southpaw Vets Ltd | Professional & scientific | 2020 |
| Southrop Farm (1994) Limited | Agriculture & fishing | 1994 |
| SOW Your Own Ltd | Wholesale & retail | 2020 |
| Space Contained Ltd | Transport & logistics | 2007 |
| Space Tree Holdings Limited | Financial services | 2025 |
| Specialist Lifting Solutions Limited | Manufacturing | 2012 |
| Spellbound Pictures Ltd | Information & communication | 2006 |
| Spencerbouchier Ltd | Information & communication | 2026 |
| Spiller Medical Consultancy Limited | Professional & scientific | 2011 |
| Spinaker Lake (Lake 9) Limited | Arts & recreation | 1992 |
| Spiorad Limited | Information & communication | 2020 |
| SPL Events Transport Limited | Transport & logistics | 2026 |
| SPL Freehold Ltd | Real estate | 2024 |
| Sports Stars (Sports Marketing Services) Limited | Professional & scientific | 2007 |
| Sprig Products Ltd | Wholesale & retail | 2023 |
| Spring Paddocks Equine Ltd | Professional & scientific | 2011 |
| Square House (Consultancy) LLP | | 2018 |
| ST James (Cheltenham) Limited | Real estate | 2024 |
| ST Mary's Limited | Transport & logistics | 2002 |
| ST. James's Place Acquisition Services Limited | Financial services | 2011 |
| ST. James's Place Charitable Foundation | Other services | 2011 |
| ST. James's Place Corporate Secretary Limited | Professional & scientific | 2014 |
| ST. James's Place DFM Holdings Limited | Financial services | 2015 |
| ST. James's Place International Distribution Limited | Professional & scientific | 2013 |
| ST. James's Place Investment Administration Limited | Financial services | 2013 |
| ST. James's Place Nominees Limited | Financial services | 2013 |
| ST. James's Place Partnership Services Limited | Administrative & support | 2012 |
| ST. James's Place PLC | Professional & scientific | 1996 |
| ST. James's Place UK PLC | Financial services | 1991 |
| ST. James's Place Unit Trust Group Limited | Financial services | 1969 |
| ST. James's Place Wealth Management Group Limited | Professional & scientific | 1991 |
| ST. James's Place Wealth Management PLC | Financial services | 2000 |
| ST. James’S Place Investment Management Limited | Financial services | 1992 |
| St.James's Place (PCP) Limited | Administrative & support | 1992 |
| St.James's Place Management Services Limited | Administrative & support | 1991 |
| Stable Cottage Southrop Ltd | Hospitality | 2015 |
| Stacey Electrical Installation Services Limited | Construction | 2012 |
| Stage : Planning Conditions Ltd | Professional & scientific | 2021 |
| Stalwart Solutions Limited | Information & communication | 2016 |
| Stamp Energy Consulting Limited | Professional & scientific | 2017 |
| Stanton Court Limited | Professional & scientific | 2012 |
| Starlisa Care Group Ltd | Health & social care | 2020 |
| Starspeed Training Limited | Transport & logistics | 2003 |
| Starts With Self Ltd | Wholesale & retail | 2026 |
| Statehouse Financial Management Limited | Financial services | 2003 |
| Stay on the Lakes Ltd | Real estate | 2022 |
| Steadings Community Management Trust | Professional & scientific | 2019 |
| Steadings Farming Ltd | Agriculture & fishing | 2017 |
| Steaditec Limited | Information & communication | 2009 |
| Stealth Group Ltd | Financial services | 2022 |
| Stealth IT Ltd | Information & communication | 2020 |
| Stem Aviation Ltd | Transport & logistics | 2020 |
| Stephen Hunt Sports Management Limited | Administrative & support | 2017 |
| Stephen Perkins Limited | Manufacturing | 2002 |
| Steve Pugh Logistics Ltd | Transport & logistics | 2007 |
| Steve Tech Ltd | Administrative & support | 2025 |
| Steven Hiscocks Ltd | Construction | 2010 |
| Stevens J Limited | Wholesale & retail | 2016 |
| Stevenson COX Property Ltd | Construction | 2026 |
| Still Property Ltd | Households | 2026 |
| Stnds Collective Ltd | Wholesale & retail | 2026 |
| Stonebridge Homecare Ltd | Health & social care | 2025 |
| Storm Motorsport Limited | Wholesale & retail | 2025 |
| Story Grove Ltd | Information & communication | 2025 |
| Stow and Digbeth Properties Ltd | Real estate | 1996 |
| Strait Systems Limited | Administrative & support | 2009 |
| Strategic Asset Protection Ltd | Financial services | 2016 |
| Strategic Environmental Solutions Ltd | Professional & scientific | 2006 |
| Strategy Planning & Solutions Limited | Professional & scientific | 2005 |
| Stratford Building Services Limited | Construction | 2005 |
| Stratone Financial Limited | Financial services | 2010 |
| Stratton Rock Limited | Financial services | 2016 |
| Street Cottage Ltd | Real estate | 2021 |
| Stronger for Longer Ltd | Health & social care | 2005 |
| Studee Ltd | Education | 2009 |
| Studio BDY Ltd | Professional & scientific | 2021 |
| Studio Hoo-Ga Limited | Professional & scientific | 2016 |
| Studio Nash Ltd | Professional & scientific | 2014 |