| Stanground Ales Limited | Hospitality | 2019 |
| Stanley Building Ltd | Construction | 2022 |
| Stansfield House Holdings Ltd | Financial services | 2021 |
| Stanworth Management Company Limited | Administrative & support | 2015 |
| Star Asphalt Limited | Professional & scientific | 2003 |
| Star Cars (Lancs) Limited | Transport & logistics | 2016 |
| Star Surveys Ltd. | Professional & scientific | 1990 |
| Starlight Services Ltd | Administrative & support | 2016 |
| Starline (Holdings) Limited | Real estate | 1953 |
| Starpence Commercial Limited | Real estate | 2025 |
| Starpence Ltd | Real estate | 2025 |
| Start Ventures Limited | Administrative & support | 2023 |
| Station House Lancaster Ltd | Hospitality | 2022 |
| Statusdesign.Co.Uk (Creative) Limited | Professional & scientific | 2010 |
| Stav-Moto Limited | Wholesale & retail | 2018 |
| STC (Software Testing Consultants) Limited | Information & communication | 2006 |
| Steel Hippo Consulting Ltd | Extraterritorial | 2012 |
| Steel Hippo Ltd | Information & communication | 2012 |
| Steeley News Ltd | Wholesale & retail | 2017 |
| Steeplefield Limited | Administrative & support | 2017 |
| Steer North Ltd | Professional & scientific | 2026 |
| Stella Creative Limited | Administrative & support | 2024 |
| Stella Rossa Design and Build Ltd | Construction | 2020 |
| Stellar Precision Engineering Ltd | Professional & scientific | 2022 |
| Stem Business Consultancy Ltd | Professional & scientific | 2025 |
| Stenet Services Limited | Construction | 2011 |
| Step UP Fashion Ltd | Wholesale & retail | 2020 |
| Stephen Atkinson (Civil Engineering) Limited | Construction | 2015 |
| Stephen Dilworth Building Contractors Limited | Construction | 2007 |
| Stephen Mcmaster Limited | Professional & scientific | 2016 |
| Stephen Threlfall Limited | Information & communication | 2021 |
| Stephen Walsh Consultancy Limited | Professional & scientific | 2020 |
| Stephens Medical Services Limited | Health & social care | 2023 |
| Stepwise Recovery Limited | Information & communication | 2025 |
| Sterdec Construction Ltd | Construction | 2021 |
| Sterling Northern Services Limited | Extraterritorial | 2006 |
| Sterling Northern Systems Limited | Professional & scientific | 2003 |
| Steve Birchall Poultry Services Limited | Agriculture & fishing | 2001 |
| Steve Carter Commercial & Plant Limited | Administrative & support | 2009 |
| Steve Forrest Builders Limited | Construction | 2003 |
| Steve Lister Tyres Ltd | Wholesale & retail | 2006 |
| Steve Sage Eyewear Limited | Wholesale & retail | 2010 |
| Steven Harper Logistics Ltd | Transport & logistics | 2019 |
| Steven Wrigley Van Sales Ltd | Wholesale & retail | 2014 |
| Stevenson's Trade Centre Limited | Wholesale & retail | 2017 |
| Stewart Fersina Holdings Limited | Professional & scientific | 2009 |
| Stewart Grieve Design Ltd | Information & communication | 2015 |
| Stewart Knowles Limited | Construction | 2025 |
| Stewart Longton Caravans Limited | Wholesale & retail | 1981 |
| Stickersworld Ltd | Wholesale & retail | 2017 |
| Stickytape & Staples Ltd | Construction | 2021 |
| STM & Orient Stone Paving Limited | Construction | 2011 |
| Stockford Recruitment Ltd | Administrative & support | 2024 |
| Stocks Lane Properties Ltd | Real estate | 2023 |
| Stonebirch Limited | Real estate | 2023 |
| Stonebridge Care Limited | Health & social care | 2026 |
| Stonechapel Limited | Professional & scientific | 2003 |
| Stonegate Surveyors Ltd | Real estate | 2020 |
| Stonehaven Management Company Ltd | Households | 2025 |
| Stop Press Limited | Wholesale & retail | 2015 |
| Storm Developments UK Limited | Wholesale & retail | 2005 |
| Stove Service (Northallerton) Limited | Manufacturing | 2016 |
| Stow Services Limited | Construction | 2015 |
| Straightforward Business Improvements Ltd | Administrative & support | 2011 |
| Straits & Stones Limited | Health & social care | 2022 |
| Strategic Financial Portfolios Limited | Extraterritorial | 2005 |
| Strategic IOT Ltd | Information & communication | 2022 |
| Stratos Engineering Ltd | Information & communication | 2011 |
| Stratus Investments Limited | Real estate | 2017 |
| Strawberry Fields Cafe (Chorley) Ltd | Hospitality | 2012 |
| Strawberry Fields Nursery & Preschool Limited | Health & social care | 2018 |
| Strawberry Fields Swim Academy Ltd | Arts & recreation | 2020 |
| Streamline Shutters Limited | Construction | 2021 |
| Stressforless Limited | Wholesale & retail | 2021 |
| Stretton & Associates Limited | Professional & scientific | 2014 |
| Stretton Development Limited | Real estate | 2000 |
| Stringfellow Building Contractors Ltd. | Construction | 1996 |
| Strip TEC UK Ltd | Manufacturing | 2024 |
| Stronger SEO Ltd | Information & communication | 2020 |
| Structural Design Engineering Limited | Professional & scientific | 2019 |
| Structural Timber Systems Ltd | Manufacturing | 2018 |
| Stuart Wren Ltd | Wholesale & retail | 2022 |
| STUD1O Chorley Ltd | Professional & scientific | 2025 |
| Studholme - Bell Limited | Professional & scientific | 2003 |
| Studio 3 North West Ltd | Arts & recreation | 2019 |
| Studio 97 Limited | Other services | 2022 |
| Studio RTR Limited | Information & communication | 2015 |
| Style Catering Limited | Hospitality | 2023 |
| Style Design & Architecture Limited | Professional & scientific | 2007 |
| SU Long Consulting Ltd | Professional & scientific | 2022 |
| SUB 6 Limited | Information & communication | 2002 |
| Subby Cashback Ltd. | Administrative & support | 2019 |
| Subsea and Sea Limited | Administrative & support | 2012 |
| Substance Europe Limited | Manufacturing | 2008 |
| SUE Halsall Limited | Other services | 2017 |
| Sue’S Secretarial Services Ltd | Administrative & support | 2026 |
| Sugar by Tamara Ltd | Hospitality | 2026 |
| Suitable Financial Advice Ltd | Financial services | 2004 |
| Suite Heat Ltd | Construction | 2019 |
| Sukhadia Garbaddas Bapuji & Sons (UK) Ltd | Hospitality | 2016 |