| South Lancashire Consulting Ltd | Extraterritorial | 2015 |
| South Leicester Rugby Football Club Limited | Arts & recreation | 2010 |
| South Ribble Gymnastics Ltd | Education | 2025 |
| South Street Homes Limited | Construction | 2014 |
| South Wales Furniture Limited | Manufacturing | 2016 |
| Southampton Cars Limited | Wholesale & retail | 2014 |
| Southeast Groundworks & Building Services Ltd | Construction | 2016 |
| Southern Business Consultants Limited | Professional & scientific | 2015 |
| Southgate Avenue Ltd | Real estate | 2026 |
| Southport.Gb.Com Ltd | Information & communication | 2000 |
| Sovereign Industrial Services Ltd | Construction | 2020 |
| Sovereign Jewellers Limited | Wholesale & retail | 2024 |
| Spa Satori Ltd | Arts & recreation | 2010 |
| Spade Mill Logistics Ltd | Transport & logistics | 2017 |
| Spare and Square Limited | Manufacturing | 2022 |
| Spark Careers Limited | Education | 2018 |
| Sparkle Cellar Services LLP | | 2026 |
| Sparkle Glasswashers Limited | Other services | 2018 |
| SPC International Limited | Manufacturing | 2003 |
| SPD Investment Holdings Limited | Financial services | 2013 |
| Speak to a Human Ltd | Information & communication | 2025 |
| Spear Brickwork Ltd | Construction | 2021 |
| Special ALE Service Limited | Hospitality | 2004 |
| Special Events (Bristol) Limited | Manufacturing | 1999 |
| Specialised Solutions Ltd | Construction | 2019 |
| Specialist Professional Services Limited | Administrative & support | 2007 |
| Specialist Vehicle Installations Ltd | Professional & scientific | 2019 |
| Spectre Construction and Development Limited | Construction | 2020 |
| Spectrum Leisure Limited | Arts & recreation | 2023 |
| Spectrum Tile Centre Limited | Construction | 2025 |
| Speed Medical Examination Services Limited | Health & social care | 1998 |
| Speed Rehab Limited | Health & social care | 2015 |
| Speedi Trades Ltd | Information & communication | 2026 |
| Speedy JET Plumbers Limited | Construction | 2019 |
| Speedy Transport Couriers Limited | Transport & logistics | 2020 |
| Speedzee Logistics Ltd | Transport & logistics | 2024 |
| Spencer Lavery Properties Ltd | Real estate | 2025 |
| Spinbackevents-Uk Ltd | Arts & recreation | 2025 |
| Spindex Limited | Manufacturing | 2014 |
| Spinney Financial Services Limited | Professional & scientific | 2024 |
| Spitalfields House Limited | Wholesale & retail | 2022 |
| Spizmedia Limited | Information & communication | 2003 |
| SPL Landscapes Limited | Administrative & support | 2019 |
| Splashout Fitted Bathrooms & Hot Tubs Limited | Wholesale & retail | 2002 |
| Splatz Ltd | Health & social care | 2014 |
| Splice Cast Limited | Manufacturing | 2004 |
| Splinter Media Productions Limited | Professional & scientific | 2012 |
| Sport's Future Ltd | Arts & recreation | 2013 |
| Sportsworld Travel Ltd | Administrative & support | 2016 |
| Spotlight Childrens' Services Ltd | Health & social care | 2011 |
| Spotted Cat Investments Limited | Hospitality | 2016 |
| Springbank Developments Limited | Construction | 2020 |
| Springbank Luxury Boarding Ltd | Professional & scientific | 2004 |
| Springbank Slate & Stone Limited | Construction | 2013 |
| Springside Gardens (Whittle LE Woods) Management Company Limited | Households | 2008 |
| Spruehub Limited | Wholesale & retail | 2026 |
| Sqlbytes Ltd | Information & communication | 2022 |
| Square One Relocations Ltd | Transport & logistics | 2009 |
| Square Zero-Solutioneers Ltd | Professional & scientific | 2018 |
| SR Signature Academy Limited | Education | 2018 |
| SR Signature Limited | Wholesale & retail | 2018 |
| SR Strategic Sourcing Ltd | Professional & scientific | 2014 |
| SR Supply Chain Consultants Ltd | Professional & scientific | 2007 |
| SR Therapy Centre Ltd | Health & social care | 2022 |
| SRC Northwest Ltd | Construction | 2023 |
| Srcostings Ltd | Professional & scientific | 2018 |
| SRE Capital Limited | Administrative & support | 2026 |
| SRE Collections Limited | Administrative & support | 2026 |
| SRE PNE Limited | Energy | 2026 |
| SRK2 Development & Investments Ltd | Construction | 2025 |
| SRM Care Ltd | Health & social care | 2014 |
| SRP Building Services Limited | Construction | 2024 |
| SRS & PAS Limited | Real estate | 2010 |
| SRS Leisure Limited | Hospitality | 2004 |
| SRS Pharma Limited | Wholesale & retail | 2015 |
| SS Greengrocers Ltd | Wholesale & retail | 2023 |
| Ssam Legal Limited | Professional & scientific | 2015 |
| ST Anta Limited | Professional & scientific | 2002 |
| ST Georges Plaice Ltd | Hospitality | 2021 |
| ST James Lodge Management Company (Leyland) Limited | Professional & scientific | 1986 |
| ST James Medical Services Ltd | Health & social care | 2012 |
| ST Joseph's Little Rascals Ltd | Arts & recreation | 2009 |
| ST Lawrence Investment & Pension Solutions Limited | Extraterritorial | 2002 |
| ST Michael's Church of England Academy Trust | Education | 2011 |
| ST Paul Design & Build Ltd | Construction | 2026 |
| ST Thomas Property Management Ltd | Real estate | 2022 |
| St&R Limited | Other services | 2012 |
| St&R Systems Limited | Administrative & support | 2015 |
| ST. George's House (Manco) Limited | Real estate | 2020 |
| Stable View Cattery Limited | Agriculture & fishing | 2021 |
| Stableit Limited | Information & communication | 2019 |
| Stac Construction Management Ltd | Construction | 2021 |
| Stack 404 Ltd | Information & communication | 2023 |
| Stafford & Co. Ltd. | Extraterritorial | 2001 |
| Stafford Financial Planning Ltd | Extraterritorial | 2003 |
| Staffs PFA Limited | Financial services | 2014 |
| Stainless Furniture Limited | Professional & scientific | 2019 |
| Stalone Brazilian JIU Jitsu Clothing Ltd | Education | 2021 |
| Stan Ainsworth & Co. Limited | Manufacturing | 2002 |
| Standout Developments Ltd | Construction | 2020 |