| Samscaping Tree and Garden Services Ltd | Agriculture & fishing | 2026 |
| Samuel Jenson Limited | Transport & logistics | 2018 |
| SAN Marco Deliveries Ltd | Hospitality | 2021 |
| Sandra Lynn Ryan Limited | Extraterritorial | 2023 |
| Sandy Boot Properties Ltd | Real estate | 2020 |
| Sandy's Discount Warehouse Limited | Wholesale & retail | 1965 |
| Sansa Property Limited | Real estate | 2024 |
| Santos Building Solutions Ltd | Construction | 2020 |
| Sanwood Limited | Wholesale & retail | 2022 |
| Sapient Wealth Management Ltd | Financial services | 2006 |
| Sarah V Homes Limited | Real estate | 2022 |
| Sarange (Heskin) Limited | Wholesale & retail | 2009 |
| Sarlinda Ltd | Administrative & support | 2024 |
| Sarofia Ltd | Other services | 2025 |
| Sasaki International Limited | Wholesale & retail | 1997 |
| Satts Haul Limited | Transport & logistics | 2019 |
| Savage Technologies Ltd | Professional & scientific | 2016 |
| Save Hardware Ltd | Wholesale & retail | 2025 |
| Savernake Ventures Ltd | Hospitality | 2019 |
| Savi Logistics Ltd | Transport & logistics | 2025 |
| Saving-You.Com Limited | Professional & scientific | 2004 |
| Savva Associates Limited | Professional & scientific | 2007 |
| Sawasdee Market Ltd | Hospitality | 2019 |
| Sawdust Loft Conversions & Joinery Ltd | Construction | 2020 |
| SB Cladding Limited | Construction | 2016 |
| SBC Group 2020 Limited | Financial services | 2020 |
| SBC Manufacturing Limited | Construction | 2020 |
| SBD Hospitality Ltd | Hospitality | 2026 |
| Sbee Consulting Ltd | Professional & scientific | 2019 |
| Sbeih Limited | Other services | 2018 |
| SBK Mini Market Ltd | Wholesale & retail | 2021 |
| Scambler Plant Hire Limited | Administrative & support | 2018 |
| Scan Logistics Limited | Transport & logistics | 2019 |
| Scanbox Entertainment Limited | Information & communication | 1996 |
| Scenic Outdoor Theatre Ltd | Arts & recreation | 2022 |
| Scheherazade Ltd. | Information & communication | 2017 |
| Schudio Ltd | Information & communication | 2011 |
| SCI Fit UK Limited | Real estate | 1999 |
| Sciana Systems Limited | Manufacturing | 2020 |
| Science Recruitment UK Ltd | Administrative & support | 2020 |
| Scot Lang Windows Doors and Conservatories Ltd | Construction | 2018 |
| Scotmex Hospitality Ltd | Hospitality | 2019 |
| Scottex Precision Textiles Limited | Manufacturing | 1978 |
| Scotts' Property Sales and Lettings (Chorley) Limited | Real estate | 2012 |
| Scoville Group Limited | Other services | 2022 |
| SCP (NW) Limited | Real estate | 2024 |
| Scrap Car Northwest Limited | Wholesale & retail | 2025 |
| Scrapbusters Limited | Administrative & support | 2011 |
| Screen Print Promotions Limited | Manufacturing | 1987 |
| Screentek International Ltd | Manufacturing | 2014 |
| Sculptra Limited | Health & social care | 2022 |
| SD & AS Property Limited | Real estate | 2026 |
| SD Holberry Builders Ltd | Construction | 2018 |
| Sdhm Ltd | Hospitality | 2021 |
| Sdmg Limited | Households | 2010 |
| SE Healthcare Solutions UK Ltd | Health & social care | 2024 |
| SE15 Ltd | Administrative & support | 2024 |
| Sea Glass Services Ltd | Real estate | 2015 |
| Seacontrol UK Ltd | Professional & scientific | 2024 |
| Seal & Valve Services UK Ltd | Manufacturing | 2001 |
| Seal Interiors Limited | Construction | 2014 |
| Sean Acaster Construction & Joinery Ltd | Construction | 2020 |
| Searchlight Holdings Limited | Extraterritorial | 2009 |
| Searchlight Investments Limited | Extraterritorial | 1988 |
| Seatpod Ltd | Construction | 2021 |
| SEC Storage Limited | Construction | 2014 |
| Secco Enterprises Limited | Financial services | 2019 |
| Seccure IT Ltd | Professional & scientific | 2022 |
| Second Opinion Design & Build London Ltd | Construction | 2019 |
| Secrets @ Dark Hair & Beauty Limited | Other services | 2015 |
| Secure Assure Limited | Information & communication | 2009 |
| Secure Cloud Services Ltd | Information & communication | 2022 |
| Sedman Wrathall Ltd | Other services | 2000 |
| SEG Aviation Ltd | Professional & scientific | 2023 |
| Segment 33 Limited | Health & social care | 2013 |
| Segwagwe Services Limited | Health & social care | 2015 |
| SEL Investments Ltd | Financial services | 2002 |
| Select Renewables and Electrical Services Ltd | Construction | 2019 |
| Selmas Limited | Professional & scientific | 2021 |
| Sena Property Limited | Financial services | 2024 |
| Senan Food Ltd | Hospitality | 2025 |
| Send Direct Limited | Transport & logistics | 1999 |
| Sengwah Creations Limited | Wholesale & retail | 2015 |
| Senior Soccer Ltd | Arts & recreation | 2024 |
| Senlac B & B Ltd | Hospitality | 2016 |
| Sense and Discover Limited | Education | 2025 |
| Sense Studios & Wellness Limited | Arts & recreation | 2025 |
| Sententia Software Limited | Information & communication | 2009 |
| Sentex Associates Limited | Real estate | 2017 |
| Sentryiq Ltd | Information & communication | 2025 |
| Serendipity Care Services Limited | Public administration | 2022 |
| Serpentyne Ltd | Professional & scientific | 2015 |
| Serveit Technology Limited | Information & communication | 2023 |
| Service Sport (UK) Limited | Professional & scientific | 1999 |
| Servicesport (Europe) Limited | Manufacturing | 2005 |
| Servicesport (Properties) Limited | Extraterritorial | 2009 |
| Servicesport Group Limited | Financial services | 2019 |
| Setas Investments Ltd | Manufacturing | 2021 |
| Setpoint Engineering Ltd | Professional & scientific | 2025 |
| Seven Performance Group Limited | Wholesale & retail | 2025 |