| Russel Court Management Company Limited | Households | 2019 |
| Russell Henville Consulting Limited | Professional & scientific | 2009 |
| Rustic Designs (NW) Ltd | Manufacturing | 2024 |
| Rustic Touch Limited | Wholesale & retail | 2006 |
| Rutherford Developments Limited | Real estate | 2012 |
| Rutlidge Properties Ltd | Real estate | 2023 |
| Ruttle Contracting Limited | Construction | 2019 |
| Ruttle Group Limited | Real estate | 2016 |
| Ruttle Plant (Midlands) Limited | Administrative & support | 1999 |
| Ruttle Plant (North East) Limited | Construction | 2004 |
| Ruttle Plant Hire Limited | Real estate | 2018 |
| Ruttle Projects Limited | Real estate | 2026 |
| Ruttle Sales Limited | Wholesale & retail | 2019 |
| RV & TM Taylor Limited | Other services | 2016 |
| RW Accountants Limited | Professional & scientific | 2019 |
| Rwts Ltd | Professional & scientific | 2025 |
| Ryan & Molyneux Transport Limited | Transport & logistics | 2015 |
| Ryan Cartwright Consultancy Ltd | Information & communication | 2023 |
| Ryan Scott Transport Ltd | Transport & logistics | 2025 |
| Ryan Wilson Freelance Biopharma Services Limited | Professional & scientific | 2024 |
| Ryesafety Limited | Professional & scientific | 2018 |
| Ryhann Properties Limited | Real estate | 2019 |
| Rymeg Limited | Administrative & support | 2013 |
| Rytetype Limited | Wholesale & retail | 2003 |
| S & a Construction (Somerset) Ltd | Construction | 2021 |
| S & a Event Medical Ltd | Health & social care | 2017 |
| S & EE Traction Ltd | Administrative & support | 2018 |
| S & I Investments Limited | Real estate | 2003 |
| S & J Engineering (UK) Limited | Construction | 2014 |
| S & J Entertainments Ltd | Hospitality | 2019 |
| S & P Drive Limited | Education | 2012 |
| S & T Hospitality Ltd | Hospitality | 2024 |
| S B Properties & Lettings Limited | Real estate | 2017 |
| S D Carpentry Limited | Construction | 2006 |
| S Fairclough Properties Ltd | Real estate | 2018 |
| S J Builders (Surrey) Limited | Construction | 2016 |
| S Johnston Transport Limited | Transport & logistics | 2018 |
| S K Rigbye Limited | Transport & logistics | 2013 |
| S M Developments (NW) Limited | Real estate | 2024 |
| S M Roocroft Limited | Construction | 2003 |
| S P & G Lettings Limited | Real estate | 2024 |
| S Phillipson Plumbing and Heating Ltd | Construction | 2016 |
| S R Bell Carpentry and Building Ltd | Manufacturing | 2019 |
| S R Night Limited | Real estate | 2025 |
| S Singh Food & Wine Ltd | Wholesale & retail | 2023 |
| S Swim Academy Ltd | Education | 2021 |
| S Trans Services Ltd | Administrative & support | 2018 |
| S&L Garage Equipment Ltd | Other services | 2023 |
| S&R Property Investment Group Ltd | Real estate | 2026 |
| S-Mech Ltd | Administrative & support | 2014 |
| S. C. Electrical (North West) Limited | Construction | 2016 |
| S.A. Turner Electrical Ltd | Construction | 2013 |
| S.D. Transport Cover Limited | Wholesale & retail | 2016 |
| S.J. Enterprises (Chorley) Limited | Administrative & support | 2011 |
| S.J.S. Hire Tools Limited | Extraterritorial | 1983 |
| S.M. Tailors Ltd | Other services | 2009 |
| S.M.A.R.T Choice NW Ltd | Wholesale & retail | 2025 |
| S.Malar Ltd | Wholesale & retail | 2019 |
| S.V. Tech Limited | Professional & scientific | 1992 |
| S1ST Ltd | Administrative & support | 2020 |
| S2 & K2 Solutions Ltd | Information & communication | 2016 |
| S24 Consulting Ltd | Information & communication | 2021 |
| Saasili Ltd | Information & communication | 2022 |
| Saber Renewable Energy JV SPV Ltd | Professional & scientific | 2023 |
| Saber Renewable Energy Ltd | Energy | 2023 |
| Sabri Foods Limited | Wholesale & retail | 2011 |
| Saddles Direct Limited | Wholesale & retail | 2014 |
| Safa Hand Car Wash (Chorley) Limited | Wholesale & retail | 2024 |
| Safaripak Limited | Extraterritorial | 2025 |
| Safe and Secure Security Services Ltd | Information & communication | 2025 |
| Safe Hands Facilities Management Ltd | Administrative & support | 2018 |
| Safe World Insurance Group (UK) Limited | Financial services | 2017 |
| Safechoice (NW) Ltd | Professional & scientific | 2012 |
| Safeguard Security & Electrical Limited | Administrative & support | 2021 |
| Safeseal Warm Roofs Ltd | Construction | 2019 |
| Safety Fire & Rescue Solutions Limited | Professional & scientific | 2015 |
| Safety Warehouse Limited | Wholesale & retail | 2008 |
| Saffron Brighouse Ltd | Hospitality | 2023 |
| Saffron Hoddesdon Ltd | Hospitality | 2016 |
| Safi Care Ltd | Administrative & support | 2015 |
| Sage and Silk Hair Ltd | Other services | 2025 |
| Sage Cottage Properties Limited | Hospitality | 1976 |
| Sage's Hospitality Services Ltd | Other services | 2017 |
| Saha Capital Ltd | Real estate | 2013 |
| Saio Limited | Administrative & support | 2014 |
| Saisree Limited | Professional & scientific | 2016 |
| Sakura Solutions Ltd | Information & communication | 2016 |
| Salazar Velez Ltd | Transport & logistics | 2019 |
| Sales Geek Chorley Ltd | Professional & scientific | 2025 |
| Sales LAB Group Ltd | Real estate | 2019 |
| Saltrans Services Limited | Transport & logistics | 2016 |
| SAM Bird Motorbodies Limited | Wholesale & retail | 2018 |
| SAM International Transport Ltd | Transport & logistics | 2016 |
| SAM Stafford Nails Ltd | Other services | 2020 |
| Samantha Holl T/A the Bay Horse Inn Ltd | Professional & scientific | 2021 |
| Samantha Rose Equestrian Limited | Other services | 2025 |
| Samantha Rose Ltd | Education | 2026 |
| Samantha Rose Skin & Laser Limited | Other services | 2018 |
| Samanthajane Clothing Ltd | Wholesale & retail | 2015 |
| Samscaping Limited | Administrative & support | 2023 |