| Seymour Care Ventures Ltd | Real estate | 2024 |
| Seymour Street 1961 Limited | Extraterritorial | 2014 |
| SFC Estates Limited | Real estate | 2022 |
| SFL Contracts Ltd | Construction | 2015 |
| Sfpl Limited | Real estate | 2016 |
| SG Building and Design Ltd | Construction | 2022 |
| SGD Building Ltd | Construction | 2021 |
| SGF Roofing NW Ltd | Construction | 2025 |
| SGF Scaffolding NW Ltd | Construction | 2025 |
| SGL Developments (UK) Ltd | Construction | 2012 |
| SGV Capital Solutions UK Ltd | Real estate | 2016 |
| SH Development & Design Ltd | Real estate | 2024 |
| SH Healthcare Partners Limited | Health & social care | 2026 |
| Shackerley (Holdings) Group Limited | Manufacturing | 1983 |
| Shackerley Facades Limited | Extraterritorial | 1993 |
| Shad Management Limited | Administrative & support | 2007 |
| Shakes&Smokes Limited | Hospitality | 2025 |
| Shama Masood Iqbal Ltd | Health & social care | 2025 |
| Shand Group Limited | Professional & scientific | 2016 |
| Shannon Sealants Limited | Construction | 2012 |
| Shaping a Vision Ltd | Professional & scientific | 2009 |
| Share a Base Ltd | Households | 2022 |
| Sharp Logic Consultants Limited | Administrative & support | 2026 |
| Sharples Davies Limited | Administrative & support | 2000 |
| Sharrock Waste Management Ltd | Water & waste | 2024 |
| Shathi Indian Ltd | Hospitality | 2018 |
| Shauna's Support Services Limited | Administrative & support | 2022 |
| Shaw Green Group Limited | Professional & scientific | 2015 |
| Shaw Medical Limited | Health & social care | 2018 |
| Shawhill Fold Residents Association Limited | Construction | 2002 |
| Shawhill Training Limited | Professional & scientific | 2002 |
| Sheet Piling (Holdings) Limited | Financial services | 2019 |
| Sheet Piling (UK) Limited | Construction | 2012 |
| Shepherd Consulting Engineers Ltd | Professional & scientific | 2025 |
| Shepherds Farm (Cockerham) Limited | Agriculture & fishing | 1997 |
| Shepherds Logistics Limited | Transport & logistics | 2019 |
| Sheq Assure Ltd | Professional & scientific | 2023 |
| Sheq Improvement Solutions Ltd | Professional & scientific | 2006 |
| Sherburne Aviation Services Ltd | Administrative & support | 2014 |
| Sheridan Energy Supply Limited | Energy | 2025 |
| Sherpa Consultants Ltd | Information & communication | 2013 |
| Sherpa Systems Ltd | Information & communication | 2013 |
| Sherwood French Ltd | Professional & scientific | 2021 |
| Shesells Resells UN Limited | Wholesale & retail | 2025 |
| Shida Preserved Flowers Ltd | Wholesale & retail | 2020 |
| Shieldmaiden Digital Ltd | Information & communication | 2025 |
| Shields Media Consultancy Limited | Manufacturing | 2020 |
| Shifa Tech Ltd | Wholesale & retail | 2023 |
| Shift Van Hire Ltd | Administrative & support | 2026 |
| Shiloh Construction (North West) Limited | Construction | 1998 |
| Shiloh Surfacing Limited | Extraterritorial | 2015 |
| Shinelive Limited | Real estate | 2018 |
| Shire Restaurant Ltd | Wholesale & retail | 2017 |
| Shirebrook Wealth Management Limited | Extraterritorial | 2011 |
| Shireburn Investments Limited | Financial services | 2025 |
| Shivram Singh Limited | Health & social care | 2011 |
| Shop & Send Limited | Extraterritorial | 2015 |
| Shoppium Limited | Wholesale & retail | 2019 |
| Shoreham Cement Works Limited | Mining & quarrying | 2015 |
| Shorrk (UK) Ltd | Wholesale & retail | 2026 |
| Shorrock Enterprises Limited | Education | 2010 |
| Shotski Limited | Wholesale & retail | 2024 |
| Shri Trimmings Limited | Manufacturing | 2017 |
| Shropshire Fire and Security Limited | Administrative & support | 2018 |
| Shurma Ltd | Hospitality | 2021 |
| Shutters of London Limited | Wholesale & retail | 2017 |
| Shwoger Ltd | Transport & logistics | 2018 |
| SIA Imperial Ltd | Wholesale & retail | 2011 |
| Siam Supreme Ltd | Hospitality | 2016 |
| Sians Sweet Treats Limited | Manufacturing | 2021 |
| Siavash Consulting Limited | Professional & scientific | 2020 |
| SIC Tickets Limited | Administrative & support | 2017 |
| Sical Information Systems Limited | Information & communication | 1998 |
| Sienna Rules Ltd | Hospitality | 2015 |
| Sigma Tiling Ltd | Construction | 2018 |
| Sign Access Ltd | Professional & scientific | 2019 |
| Signature Landscapes Design and Build Ltd | Administrative & support | 2017 |
| Signature Luxe Cleaning Co Ltd | Administrative & support | 2026 |
| Signatures From the Heart Limited | Wholesale & retail | 2015 |
| Silcocks Extreme Rides Limited | Arts & recreation | 2024 |
| Silcocks Investments Limited | Real estate | 2001 |
| Silver Birches Financial Services Ltd | Financial services | 2013 |
| Silver Centre (UK) Limited | Extraterritorial | 2005 |
| Silver Grove Properties Limited | Construction | 2012 |
| Silver Mushroom Homewares Limited | Wholesale & retail | 2025 |
| Silver Mushroom Limited | Wholesale & retail | 2013 |
| Silverwood Design Services Limited | Extraterritorial | 1990 |
| Silvesters Farm Limited | Real estate | 2009 |
| Simit Chai Ltd | Manufacturing | 2019 |
| Simon Pendlebury Physiotherapy Ltd | Health & social care | 2022 |
| Simple AS Home Improvements Limited | Administrative & support | 2025 |
| Simple Socials Limited | Professional & scientific | 2019 |
| Simple Solutions 4 Software Limited | Extraterritorial | 2014 |
| Simply Beeutiful Holdings Limited | Financial services | 2025 |
| Simply Beeutiful Honey Limited | Agriculture & fishing | 2022 |
| Simply Care (North West) Ltd | Health & social care | 2025 |
| Simply Floors Chorley Ltd | Construction | 2016 |
| Simply Oysters & Seafood Ltd | Wholesale & retail | 2019 |
| Simply Oysters Ltd | Wholesale & retail | 2018 |
| Simply Sidemount Limited | Wholesale & retail | 2022 |