| Saffron Kitchen Chesterfield CIC | Manufacturing | 2022 |
| Safri Food & Wine Ltd | Wholesale & retail | 2022 |
| Safri Group Limited | Real estate | 2025 |
| Saftek Ltd | Wholesale & retail | 2025 |
| Sahand Barbers 14 Ltd | Other services | 2023 |
| Sahin Cleaning Ltd | Construction | 2020 |
| Saigon Nails Spa & Beauty Limited | Other services | 2021 |
| Sail (Sexual Abuse and Incest Line) | Health & social care | 2013 |
| Saint Coulson Estimating Services Ltd | Other services | 2025 |
| Saints Bar and Hub Ltd | Hospitality | 2025 |
| SAK Design T/A Nankivells Ltd | Manufacturing | 2007 |
| Saka Holdings Ltd | Real estate | 2019 |
| Saka Supplies Ltd | Wholesale & retail | 2019 |
| Saleslink Collective Ltd | Professional & scientific | 2025 |
| Sall Estates Ltd. | Real estate | 2012 |
| Sally Wragg Limited | Administrative & support | 2020 |
| Salnhem Limited | Health & social care | 2019 |
| Salon DM Limited | Other services | 2010 |
| Salon S40 Boutique Limited | Extraterritorial | 2016 |
| Saltergate Ltd | Real estate | 2015 |
| SAM RAC Contracting Limited | Construction | 2008 |
| SAML2 Ltd | Manufacturing | 2024 |
| Sams Hair Lounge Ltd | Other services | 2012 |
| Samtech Mechanical Services Limited | Construction | 2009 |
| Samuell Limited | Wholesale & retail | 2025 |
| SAN Marco Associates Limited | Professional & scientific | 2015 |
| SAN Marko Limited | Professional & scientific | 2024 |
| Sanaya Lanka Ltd | Wholesale & retail | 2026 |
| Sanctuary Inn Ltd | Hospitality | 2023 |
| Sanctuary Relaxation Limited | Hospitality | 2019 |
| Sanderson Hutton Property Limited | Real estate | 2024 |
| Sanderson's Glass & Glazing Ltd | Construction | 2022 |
| Sandicare Limited | Extraterritorial | 1995 |
| Sankey Properties Ltd | Real estate | 2016 |
| Saolis Holdings Limited | Real estate | 2019 |
| Sapphire Beauty & Aesthetics Ltd | Other services | 2019 |
| Saqer Almanar UK Ltd | Construction | 2025 |
| Sara&Sofia 19 Limited | Hospitality | 2025 |
| Sarah Bowman Limited | Hospitality | 2011 |
| Sarah Lovell Ltd | Administrative & support | 2013 |
| Sarah Peach Limited | Financial services | 2010 |
| Sarah Wilmot Limited | Other services | 2010 |
| Sarahcarefranchise Ltd | Health & social care | 2016 |
| Saramac Limited | Agriculture & fishing | 2007 |
| Sarmar (Chesterfield) Ltd | Real estate | 2024 |
| Saros Europe Ltd. | Other services | 2011 |
| Sarosuk Limited | Professional & scientific | 2023 |
| Sarren Ltd | Wholesale & retail | 2020 |
| SAS Aquatics Ltd | Agriculture & fishing | 2025 |
| SAS Developments & Lettings Ltd | Real estate | 2024 |
| SAS Homes Limited | Construction | 2017 |
| SAS Install Limited | Other services | 2017 |
| SAS Projects (Midlands) Limited | Construction | 2024 |
| SAT Square Ltd | Wholesale & retail | 2021 |
| Saturn and Stripes Ltd | Wholesale & retail | 2020 |
| Saunders Wheel Wash Limited | Wholesale & retail | 2013 |
| Savage Legal Services Limited | Professional & scientific | 2022 |
| Savery Grazing Ltd | Hospitality | 2023 |
| Savextra Limited | Wholesale & retail | 2026 |
| Savi's Place Ltd | Hospitality | 2025 |
| Savour PR Limited | Professional & scientific | 2025 |
| Saws-Global Ltd | Manufacturing | 2025 |
| Saxton MEE (Dronfield) Limited | Real estate | 2023 |
| Saxton MEE Holdings Limited | Financial services | 2020 |
| SAY IT With Soap Limited | Manufacturing | 2026 |
| SB Hewitt Construction Ltd | Construction | 2024 |
| SB Tours Ltd | Administrative & support | 2025 |
| SB Venues Ltd | Hospitality | 2025 |
| SBK Computers Ltd. | Information & communication | 1998 |
| SBK Property Limited | Real estate | 2014 |
| SBS Hardwick Limited | Hospitality | 2022 |
| SC Chicken UK Ltd | Hospitality | 2017 |
| SC Comms Limited | Professional & scientific | 2005 |
| SC Joinery & Building Services Ltd | Construction | 2026 |
| Scaffold Services (Chesterfield) Ltd | Construction | 2013 |
| Scaglia Indeva Limited | Manufacturing | 2000 |
| Scalplift Ltd | Health & social care | 2021 |
| Scanlon Properties (Midlands) Ltd | Real estate | 2018 |
| Scape Easy Limited | Construction | 2015 |
| Scaravilli Ltd | Hospitality | 2022 |
| Scarlett Beauty LDN Ltd | Other services | 2021 |
| Scarsdale Brewery Company Limited | Extraterritorial | 2011 |
| Scarsdale Green Management Company Limited | Households | 2019 |
| Scattergood Podiatry Limited | Health & social care | 2014 |
| Scavelli's Limited | Wholesale & retail | 2000 |
| Scene Streaming Limited | Health & social care | 2020 |
| Schmalz Limited | Manufacturing | 2009 |
| Schmalz UK Limited | Manufacturing | 2021 |
| Schmitz Medical UK Ltd | Manufacturing | 2026 |
| Schnuckiputzi Limited | Wholesale & retail | 2023 |
| Schoeller-Bleckmann Oilfield Equipment (UK) Limited | Mining & quarrying | 1996 |
| Science Into Limited | Professional & scientific | 2013 |
| Scoffcorp Ltd | Manufacturing | 2025 |
| Scope Electrical Contractors Ltd | Construction | 2017 |
| Scorpion Composites Development Limited | Manufacturing | 2004 |
| Scott Electrical Services (Chesterfield) Limited | Manufacturing | 1998 |
| Scott Green Associates Limited | Professional & scientific | 2005 |
| Scott Ives Double Glazing Limited | Construction | 2011 |
| Scott Marsden Electrical Limited | Construction | 2026 |
| Screed-Right Consultancy Ltd | Professional & scientific | 2021 |