| Science Fiction Space Craft Ltd | Professional & scientific | 2018 |
| Scion P and M Services Limited | Real estate | 2018 |
| Scope Business Services Limited | Professional & scientific | 1995 |
| Scott Doors Limited | Manufacturing | 1997 |
| SCR Properties Ltd | Real estate | 2002 |
| Screen INK & Solvent Supplies Ltd | Manufacturing | 1998 |
| Seal Education Limited | Professional & scientific | 2005 |
| Sean Salinger Fitness Ltd | Health & social care | 2006 |
| Searlecrest Limited | Wholesale & retail | 1982 |
| Seaview Developments (NW) Limited | Extraterritorial | 2006 |
| Second Peak Limited | Health & social care | 2026 |
| Sedgwick Automation Ltd | Information & communication | 2025 |
| Select Seven Ltd | Arts & recreation | 2007 |
| Selworth Properties Limited | Real estate | 1986 |
| Sense Network Limited | Financial services | 2007 |
| SER Limited | Information & communication | 2003 |
| Serviced City Pads Limited | Hospitality | 2007 |
| Services Design Consultants Ltd | Professional & scientific | 2018 |
| Seven Stars 4 X 4 Limited | Wholesale & retail | 2004 |
| Sever Group Limited | Administrative & support | 1967 |
| SEW Electronics Ltd | Manufacturing | 2005 |
| Shannon Technical Services Limited | Wholesale & retail | 2005 |
| Shape Consulting Limited | Professional & scientific | 2006 |
| Shape Yourself Limited | Health & social care | 2004 |
| Sharpeiq Ltd | Information & communication | 2023 |
| Shaws Fabrics Limited | Wholesale & retail | 1916 |
| Shawspeed KIT Cars Limited | Wholesale & retail | 2003 |
| Shayuz Limited | Professional & scientific | 2001 |
| Shear Magic Ltd | Construction | 2007 |
| Shepherd Bros.(Knutsford)Limited | Real estate | 1962 |
| Sherwin & Sons Contractors Limited | Agriculture & fishing | 2006 |
| Shire Professions Finance Limited | Extraterritorial | 2025 |
| Shires Art Printing Limited | Manufacturing | 1998 |
| Shirtcliffe Associates Limited | Professional & scientific | 1996 |
| Shogun Limited | Professional & scientific | 1986 |
| Shontec Ltd | Construction | 2007 |
| Shorebutton Limited | Manufacturing | 2003 |
| Shorecliffe Limited | | 2009 |
| Sigma Engineering(M/C)Limited | Wholesale & retail | 1967 |
| Sigma Manchester Limited | Wholesale & retail | 2003 |
| Signum Aviation Ltd | Transport & logistics | 2007 |
| Silcock Leedham Consulting Engineers Limited | Administrative & support | 2010 |
| Silcock Leedham Group Ltd | Administrative & support | 2010 |
| Silk Developments Ltd | Real estate | 1995 |
| Silkframe Computers Limited | Information & communication | 1985 |
| Silktown Dwellings Limited | Real estate | 1993 |
| Silver Fibre (UK) Limited | Extraterritorial | 2004 |
| Silverbrax Ltd | Other services | 2003 |
| Simbox Limited | Wholesale & retail | 2012 |
| Simoy & Simoy Holdings Ltd | Health & social care | 2016 |
| Simply ASK Wholesale Limited | Wholesale & retail | 2000 |
| Sirocco Properties Limited | Real estate | 2003 |
| SIS Property Limited | Professional & scientific | 2006 |
| Sisbro Accountants Ltd | Professional & scientific | 2021 |
| SIX Music Productions Limited | Wholesale & retail | 2005 |
| Skaramoosh Media Ltd | Information & communication | 2019 |
| Skerratt Auto Repairs Limited | Transport & logistics | 1974 |
| Skinnybitch Ltd | Manufacturing | 2025 |
| Skip Brown Cars & Components Limited | Wholesale & retail | 1985 |
| SKS (GB) Limited | Professional & scientific | 2007 |
| Skylar Nails Ltd | Other services | 2020 |
| SM Consultancy Limited | Professional & scientific | 2007 |
| Smart Carpets & Furnishings Limited | Professional & scientific | 2003 |
| Smart Furnishings (2007) Ltd | Wholesale & retail | 2007 |
| Smart Investor Hub Ltd | Professional & scientific | 2025 |
| Smarter Integration Limited | Information & communication | 2016 |
| Smartglide Interiors Limited | Wholesale & retail | 2018 |
| SMC Euroclamp Limited | Manufacturing | 1950 |
| Smcsm Limited | Administrative & support | 2012 |
| Smiths SD Limited | Administrative & support | 2003 |
| Smqa Consultancy Limited | Professional & scientific | 2019 |
| SMS Accountants Limited | Professional & scientific | 2001 |
| Snap Films Limited | Information & communication | 2026 |
| Snatch the Dog & Friends Ltd | Professional & scientific | 2003 |
| Snow Solutions Limited | Professional & scientific | 2012 |
| Snugburys Ice Cream Limited | Hospitality | 2002 |
| Softgaze Limited | Professional & scientific | 2001 |
| Solsus Limited | Professional & scientific | 2003 |
| Sonic Drilling & Piling Planthire Limited | Construction | 2012 |
| Soozoo Limited | Agriculture & fishing | 2018 |
| Source Public Relations Limited | Professional & scientific | 2007 |
| Sourcing and Supply Solutions Limited | Wholesale & retail | 2002 |
| South Manchester Jewish Student Trust Limited | Other services | 2002 |
| Southern Ecological Solutions Limited | Professional & scientific | 2007 |
| Southern Groundworks Limited | Construction | 2017 |
| Space Dimensions Limited | Administrative & support | 2004 |
| Spacehouse Limited | Professional & scientific | 2000 |
| Span Software Limited | Information & communication | 1981 |
| Span Software Products Limited | Information & communication | 1981 |
| Spark Brothers LLP | | 2004 |
| Sparkles (Hampshire) Limited | Administrative & support | 2019 |
| SPB Commercials Limited | Wholesale & retail | 2008 |
| Specdec Limited | Construction | 1997 |
| Special Piping Materials Limited | Wholesale & retail | 1988 |
| Spectrum Fasteners Limited | Manufacturing | 1998 |
| Spectus Systems (Dormant) Limited | Professional & scientific | 1986 |
| Speedy Freight Holdings Limited | Financial services | 2021 |
| Spencer Quantum Limited | Other services | 1994 |
| Spencer Wilkinson Construction Limited | Construction | 2003 |
| Sphere Group Recruitment Limited | Professional & scientific | 2000 |