| Rising Phoenix Gymnastics CIC | Education | 2025 |
| Rising Tide Audio Ltd | Information & communication | 2024 |
| Ritelux Ltd | Wholesale & retail | 2009 |
| Rivacre Ltd | Information & communication | 2021 |
| RKJ Consulting Limited | Extraterritorial | 2006 |
| Rlees Properties Limited | Real estate | 2025 |
| Roadless Tractors Limited | Wholesale & retail | 2007 |
| Roberts Northwich Limited | Financial services | 2017 |
| Robin Jones (Engineering Projects) Limited | Professional & scientific | 1985 |
| Rock Chemicals Limited | Manufacturing | 1965 |
| Rock Distributors Limited | Wholesale & retail | 1978 |
| Rock OIL Marketing Limited | Wholesale & retail | 1984 |
| Rockliffe's Repairs Limited | Construction | 2003 |
| ROE Clare Limited | Agriculture & fishing | 2003 |
| Roften Galvanizing Limited | Manufacturing | 1976 |
| Rogers & Mclaughlin Limited | Real estate | 1964 |
| Rogers Masonry Limited | Administrative & support | 2004 |
| Roland Bardsley (UK) Limited | Professional & scientific | 1972 |
| Rolinson & Co Limited | Professional & scientific | 2003 |
| Rolls-Royce & Bentley Pension Fund Trustee Limited | Administrative & support | 2007 |
| Roman Lodge Estates Limited | Real estate | 2003 |
| Rondar Signs Limited | Wholesale & retail | 2001 |
| Roofstyle UK Limited | Manufacturing | 2006 |
| Rooftops Letting & Management Limited | Real estate | 2003 |
| Roomes Decor Limited | Construction | 2002 |
| Rose Rimmer Limited | Construction | 2005 |
| Roseway Giles Limited | Extraterritorial | 1992 |
| Rossdean Limited | Real estate | 2005 |
| Rosslyn Property Developments Limited | Real estate | 2013 |
| Rovewide Limited | Other services | 1978 |
| Rowlinsons Solicitors Limited | Professional & scientific | 2007 |
| Roxburgh Consulting Limited | Professional & scientific | 2002 |
| ROY Barlow Limited | Other services | 2002 |
| ROY Newey Limited | Professional & scientific | 2004 |
| Royal Court (Northwich) Limited | Households | 2005 |
| RP Design Consulting Limited | Professional & scientific | 2017 |
| RSB Maintenance Limited | Construction | 2007 |
| RSK Countryside Management Limited | Administrative & support | 2002 |
| RSK Investments Limited | Other services | 2002 |
| RSK Orbital Limited | Other services | 1998 |
| Rubber Duck Trucking Ltd | Transport & logistics | 2016 |
| Rubber Key Games Ltd | Information & communication | 2024 |
| Rudyard Lake Limited | Arts & recreation | 1995 |
| Runcorn Vehicle Recycling Limited | Wholesale & retail | 2005 |
| Ruston-Bucyrus Ltd | Professional & scientific | 2005 |
| Rutherford Consulting Limited | Professional & scientific | 2000 |
| Rvcc UK Limited | Wholesale & retail | 2021 |
| RXM Limited | Construction | 2007 |
| Ryecroft Homes Limited | Hospitality | 2002 |
| Rytrak Limited | | 1987 |
| S & a Buckley Limited | Professional & scientific | 2002 |
| S B M Safety Solutions Limited | Professional & scientific | 2004 |
| S Cooper and Sons Limited | Transport & logistics | 1999 |
| S E T Developments Limited | Construction | 1990 |
| S F R Farming Limited | Agriculture & fishing | 2005 |
| S P Media (NW) Limited | Professional & scientific | 2003 |
| S Russell Transport Limited | Transport & logistics | 2003 |
| S&A Brothers Retail Ltd | Wholesale & retail | 2025 |
| S. Cooper Holdings Limited | Real estate | 1938 |
| S. J. Jones Limited | Other services | 2003 |
| S. Jenyon Draughting Services Limited | | 1978 |
| S.& N.Pickford(Romiley Properties)Limited | Hospitality | 1964 |
| S.& N.Pickford(Romiley)Limited | Administrative & support | 1970 |
| S.A. Ward Building Maintenance Services Limited | Construction | 2003 |
| S.D.P & Family Ltd | Real estate | 2026 |
| S.Freedman & Sons(Stockport),Limited | Wholesale & retail | 1924 |
| S.L.E. Developments Limited | Construction | 2003 |
| S.P.O. Design Limited | Professional & scientific | 2006 |
| Sabah International Leatherwear Limited | Manufacturing | 1981 |
| Safe Security Limited | Administrative & support | 1999 |
| Safety Assurance Limited | Professional & scientific | 2007 |
| Safety at Height Limited | Wholesale & retail | 2001 |
| Safu IP Holdings Limited | Financial services | 2026 |
| Saga Doors Limited | Construction | 2017 |
| Sage-Solutions (NW) Limited | Information & communication | 2007 |
| Saha Lettings Ltd | Real estate | 2021 |
| Sahib's Kitchen Limited | Hospitality | 2025 |
| SAJ Accounting Limited | Professional & scientific | 2007 |
| Sale Accounting Services Limited | Professional & scientific | 2002 |
| Sale Private Day Nursery (Holdings) Limited | Financial services | 2004 |
| Sale Private Day Nursery Limited | Education | 1996 |
| Salemicro Limited | Information & communication | 1996 |
| Salix River & Wetland Services Limited | Agriculture & fishing | 2003 |
| Salmo Engineers Limited | Manufacturing | 2003 |
| Salwood Finance Limited | | 1967 |
| SAM Dale and SON Limited | Wholesale & retail | 1955 |
| SAM Training & Consultancy Ltd | Health & social care | 2007 |
| Sand Construction Limited | Wholesale & retail | 1999 |
| Sandbach Tyre Service Limited | Wholesale & retail | 2011 |
| Sandle Heath Supplies Limited | Administrative & support | 1992 |
| Sant's Fabrications Ltd | Energy | 2006 |
| Saplingessentialservices Ltd. | Wholesale & retail | 2018 |
| Sarah Thompson Property Ltd | Real estate | 2016 |
| Satake UK Pensions Employer Limited | Administrative & support | 2010 |
| Savas & Savage Solicitors Limited | Professional & scientific | 2005 |
| Saxoncare Limited | Professional & scientific | 1988 |
| SBP Properties Limited | Real estate | 2002 |
| Scenic Windows and Conservatories Limited | Construction | 1996 |
| Schofield Precision Engineers Ltd. | Manufacturing | 2002 |
| Scholars Court Management Company (Swinton) Limited | Households | 2003 |