| Sphere Recruitment (Birmingham) Limited | Administrative & support | 2000 |
| Sphere Recruitment Ltd. | Administrative & support | 1999 |
| Spice of India (Cuerdley) Ltd | Hospitality | 2013 |
| Spicecourse Limited | Real estate | 1995 |
| Spinal Consultancy Limited | Health & social care | 2003 |
| Spindles Investment Limited | Financial services | 2015 |
| Spirals Infotech Ltd | Information & communication | 2017 |
| Spirit of the Herd: Ponies Helping People Ltd | Other services | 2018 |
| Spitfire Books Limited | Wholesale & retail | 2005 |
| Spring and Company Limited | Professional & scientific | 1991 |
| Spring Bean Ltd | Administrative & support | 2016 |
| Squarepark Limited | | 1980 |
| Squeeze Marketing Limited | Information & communication | 2007 |
| SRB Productions Limited | Information & communication | 2007 |
| SRL Pharma Ltd | Professional & scientific | 2023 |
| SS IT Consultants Ltd | Professional & scientific | 2018 |
| Ssuss Limited | Administrative & support | 1999 |
| ST Transform Ltd | Professional & scientific | 2025 |
| ST Werburgh Limited | Construction | 1999 |
| ST. James's Properties (Cheshire) Limited | Professional & scientific | 2003 |
| ST. Mark Property Limited | Real estate | 2023 |
| St.Stephen Private Ltd | Wholesale & retail | 2013 |
| Stable Plastics Limited | Manufacturing | 1966 |
| Staffordshire Fuels Limited | Wholesale & retail | 1997 |
| Staffordshire Glass Supplies Limited | Administrative & support | 2001 |
| Staly Dental Centre Limited | Health & social care | 2020 |
| Stalybridge Celtic Football Club Limited(The) | Other services | 1934 |
| Standpoint Business Systems Limited | Information & communication | 1997 |
| Star Computer Services Limited | Information & communication | 1999 |
| Starkey Group Limited | Financial services | 2004 |
| Station Garage (Knutsford) Limited | Wholesale & retail | 2003 |
| Stavely Films Limited | Information & communication | 2002 |
| Steel Thistle Press Ltd | Information & communication | 2022 |
| Steline Transport Ltd | Transport & logistics | 2017 |
| Stelway Cold Stores Limited | | 1982 |
| Stenix Limited | Professional & scientific | 2007 |
| Step-Trans (UK) Company Limited | Wholesale & retail | 2019 |
| Stephen Beesley Associates Limited | Professional & scientific | 2017 |
| Stephen Ince Limited | Administrative & support | 2002 |
| Stephenson Halliday Limited | Professional & scientific | 2001 |
| Sterling International Horse Transport Ltd | Other services | 2017 |
| Sterling Solutions Umbrella Ltd | Professional & scientific | 2003 |
| Stirling Management Group Limited | Financial services | 1982 |
| Stirling Retail Park General Partner Limited | Real estate | 2004 |
| Stirling Retail Park LP2 Limited | Administrative & support | 2004 |
| Stitch IT Promotions Ltd | Manufacturing | 2004 |
| Stockport Carpet Centre Ltd. | Wholesale & retail | 2002 |
| Stockport Grammar School (2007) Limited | Education | 1995 |
| Stockport Hydraulics Limited | Manufacturing | 2011 |
| Stockport Labour Party Club Limited | Hospitality | 1987 |
| Stockport Masonic Guildhall,Limited(The) | Other services | 1930 |
| Stockport Window Cleaning Limited | Administrative & support | 2002 |
| Stone Mine Limited | Construction | 2001 |
| Stonebridge Non-Wovens Ltd | Wholesale & retail | 2001 |
| Stones Construction Services Limited | Construction | 2004 |
| Stonewood (UK) Limited | Manufacturing | 2003 |
| Storage Equipment Inspection Services Limited | Administrative & support | 1988 |
| Storymaze Limited | Professional & scientific | 2023 |
| Straightline IT Limited | Information & communication | 2003 |
| Strands of Sandbach Limited | Other services | 2003 |
| Strategy Machinists Ltd | Manufacturing | 2014 |
| Strawberry Fields of Edwinstowe Limited | Manufacturing | 2003 |
| Strawberry Limited | Information & communication | 2007 |
| Streetwise UK Management Limited | Professional & scientific | 2004 |
| Stretford Floors Limited | Construction | 2007 |
| Stuart Rushton Employee Ownership Trustee Limited | Professional & scientific | 2026 |
| Studio One Hairdressing Limited | Other services | 2003 |
| Subway Northwest Limited | Hospitality | 2007 |
| Sugar Mill Court Limited | Households | 2004 |
| Sunbeams Limited | Health & social care | 2001 |
| Sunbeams Thorpe Park Limited | Health & social care | 2015 |
| Suncreek (Stockport) Limited | Real estate | 2006 |
| Sunderland Serviced Offices Limited | Other services | 2026 |
| Sundome Limited | Administrative & support | 1996 |
| Sunfield (Wilmslow) Residents Management Company Limited | Real estate | 2024 |
| Sunset View Properties Limited | Real estate | 2005 |
| Supreme International Limited | | 1983 |
| Surefix Joinery Limited | Construction | 2005 |
| Sutton Hotels Limited | Extraterritorial | 2004 |
| Suttons International Limited | Transport & logistics | 1967 |
| Suttons International Storage Limited | Transport & logistics | 2024 |
| Swansway Garages Limited | Wholesale & retail | 2002 |
| Swarco Hitex Ltd | Construction | 2002 |
| Swift Cooling Services Limited | Wholesale & retail | 1983 |
| Swift Financial Management Ltd | Professional & scientific | 2022 |
| Swift Holdings and Investments NW Ltd | Financial services | 2023 |
| Swiftcomp Services Limited | Information & communication | 1996 |
| Swootsy Limited | Wholesale & retail | 2024 |
| Syeda Akmal Limited | Health & social care | 2009 |
| Syingate Limited | Construction | 2019 |
| Sylhet SW Ltd | Hospitality | 2026 |
| Synchronised Finance Limited | Professional & scientific | 2007 |
| Systemattic Limited | Construction | 2000 |
| T and C Studley Limited | Real estate | 2003 |
| T and S Catering Solutions Ltd | Hospitality | 2022 |
| T Baser Ltd | Hospitality | 2015 |
| T E Hughes & SON Limited | Wholesale & retail | 1971 |
| T J B Property Management Limited | Real estate | 2003 |
| T J Enterprises Limited | Information & communication | 2006 |
| T Swindells Ltd | Professional & scientific | 2003 |