| Spelegrigo Limited | Financial services | 2022 |
| Spellbound Theatrical Productions Ltd | Arts & recreation | 2019 |
| Spencer Court (Cheltenham) Limited | Households | 1992 |
| Spencer Wilton Limited | Agriculture & fishing | 2015 |
| Spendwisely Ltd | Professional & scientific | 2024 |
| Spenley Residential Properties Ltd | Real estate | 2019 |
| Sph.Solutions Limited | Administrative & support | 2016 |
| Spindrift Consultancy Services Limited | Professional & scientific | 2018 |
| Spindrift Properties Ltd | Real estate | 2023 |
| Spinhalf UK Ltd | Information & communication | 2010 |
| Spirax Group PLC | Manufacturing | 1958 |
| Spirax Manufacturing Company Limited | Professional & scientific | 1932 |
| Spirax UK Pension Trustees Limited | Financial services | 2025 |
| Spirax-Sarco America Investments Limited | Manufacturing | 2018 |
| Spirax-Sarco America Limited | Professional & scientific | 2011 |
| Spirax-Sarco Engineering B.V. | | 2002 |
| Spirax-Sarco Engineering Limited | Financial services | 2024 |
| Spirax-Sarco Europe Limited | Professional & scientific | 1978 |
| Spirax-Sarco International Limited | Professional & scientific | 1978 |
| Spirax-Sarco Investments B.V. | | 2002 |
| Spirax-Sarco Investments Limited | Professional & scientific | 1909 |
| Spirax-Sarco Limited | Manufacturing | 1952 |
| Spirax-Sarco Overseas Limited | Professional & scientific | 1980 |
| Spirez Properties Ltd | Real estate | 2020 |
| Spirit Architecture Limited | Construction | 2009 |
| Spirit of Football Community Interest Company | Arts & recreation | 2009 |
| SPL Carpentry Limited | Manufacturing | 2021 |
| Splash of Taste LP | | 2022 |
| Splash of Taste Online Ltd | Information & communication | 2024 |
| Splashback Art Limited | Arts & recreation | 2019 |
| Split Property Ltd | Real estate | 2023 |
| SPM Homes Ltd | Construction | 1988 |
| SPM Technical Services Ltd | Manufacturing | 2017 |
| Spoco Limited | Professional & scientific | 2007 |
| Spoke Services Limited | Professional & scientific | 2024 |
| Sport Active Camps South West Ltd | Education | 2020 |
| Sport Tours Italia Ltd. | Administrative & support | 2017 |
| Sportcoach Ltd | Administrative & support | 2022 |
| Sportpar Limited | Arts & recreation | 1980 |
| Spot on Ales Limited | Hospitality | 2025 |
| Spotted Dog Properties Ltd | Real estate | 2021 |
| SPR Standard Limited | Professional & scientific | 2015 |
| Sprayfoam Advice Centre Limited | Information & communication | 2024 |
| Sprayroad Markings Ltd | Construction | 2019 |
| Spreadsheets & Burgers Ltd | Professional & scientific | 2022 |
| Spring and Autumn Chinese Limited | Hospitality | 2019 |
| Spring Cleaning Services Limited | Other services | 2001 |
| Spring Forward Landscaping Ltd | Administrative & support | 2018 |
| Spring Propco Ltd | Real estate | 2021 |
| Spring Stone Energy Limited | Professional & scientific | 2018 |
| Springbank Community Group CIC | Hospitality | 2020 |
| Springfinch Ltd | Real estate | 2022 |
| Springhill Cottage Ltd | Hospitality | 2023 |
| Springs CSP Ltd | Information & communication | 2024 |
| Springview Fields Ltd | Households | 2022 |
| Springwood House RTM Company Ltd | Households | 2016 |
| Sprkflow Ltd | Professional & scientific | 2024 |
| Sprout Consultants Ltd | Administrative & support | 2024 |
| SPS Plastering and Partitions Ltd | Construction | 2017 |
| SPS Property Development Limited | Construction | 2021 |
| Spuggs Limited | Information & communication | 2014 |
| Spurso Limited | Information & communication | 2024 |
| SPY Station X Ltd | Arts & recreation | 2025 |
| Square One Software Limited | Information & communication | 2018 |
| Square Pegs - Children and Young People Ltd. | Education | 2019 |
| Squashed Robot Films Ltd | Information & communication | 2024 |
| Squee Limited | Information & communication | 2024 |
| Squidsoup Limited | Information & communication | 2018 |
| Squidsoup.Org | Information & communication | 2002 |
| Squirrelled Holdings Limited | Information & communication | 2021 |
| Squirrelled Limited | Information & communication | 2020 |
| SR Cheltenham Ltd | Hospitality | 2025 |
| SRD Partners Limited | Financial services | 2024 |
| SRG Finance Ltd | Financial services | 2017 |
| SRH International Consulting Limited | Wholesale & retail | 2013 |
| SRI Guru Lettings Limited | Real estate | 2019 |
| SRI Guru Venture Limited | Financial services | 2026 |
| SRI Lakshmi Venkateswara Foods Ltd | Hospitality | 2022 |
| SRI Praajna Engineering Consultancy Services Limited | Professional & scientific | 2011 |
| SRK Equipments Ltd | Health & social care | 2025 |
| SRT Consultancy Ltd | Professional & scientific | 2024 |
| SRV Roofing & Building Services Ltd | Construction | 2022 |
| SSB Cotgrave Ltd | Energy | 2014 |
| SSC Holdco (UK) Limited | Manufacturing | 2016 |
| SSC Intermediateco Limited | Financial services | 2016 |
| SSF Welding Ltd | Information & communication | 2018 |
| Sstvsound Ltd | Information & communication | 2025 |
| Ssvs Housing Ltd | Real estate | 2023 |
| ST Catherine's (Cheltenham) Management Company Limited | Households | 2001 |
| ST Edward's Outdoor Education Ltd | Education | 2025 |
| ST Edward's School Cheltenham Limited | Education | 2021 |
| ST Edwards Senior School Limited | Education | 2023 |
| ST George's Terrace (Cheltenham) RTM Company Limited | Households | 2022 |
| ST Georges Park Bakery Ltd | Manufacturing | 2018 |
| ST James Court (Cheltenham) Limited | Households | 1984 |
| ST James North (Cheltenham) Limited | Households | 2019 |
| ST James North 1 RTM Company Limited | Households | 2015 |
| ST James South 1 (Cheltenham) Management Limited | Households | 2017 |
| ST James South 1 RTM Company Limited | Households | 2012 |
| ST Leonard's Nominees Limited | Professional & scientific | 2023 |