| Soul Sanctuary UK. Ltd | Health & social care | 2026 |
| Soul Train Promotions Ltd | Other services | 2015 |
| Soul:Ciné C.I.C. | Information & communication | 2025 |
| Soule Enterprise Limited | Real estate | 2025 |
| Sound Records Stroud Ltd | Wholesale & retail | 2022 |
| Sound Travels Limited | Wholesale & retail | 2012 |
| Soundlevel Ltd | Information & communication | 2008 |
| Source Code Marketing Limited | Professional & scientific | 2014 |
| Source LED Ventures Limited | Financial services | 2022 |
| Souter Point Limited | Professional & scientific | 2015 |
| South Bank Marine Limited | Real estate | 1962 |
| South Cerney Builders Limited | Construction | 2015 |
| South Hayes Ltd | Construction | 2025 |
| South Street Bess Limited | Energy | 2023 |
| South Tower Lettings Limited | Real estate | 2022 |
| South West Design Limited | Professional & scientific | 2022 |
| South West Fund (General Partner) Limited | Financial services | 1993 |
| South West Heating Services Bristol Limited | Other services | 2025 |
| South West Heating Services Ltd | Other services | 2019 |
| South West Plant Ltd | Professional & scientific | 2008 |
| South West Property Group Limited | Real estate | 2020 |
| South West Refurbishments Ltd | Construction | 2011 |
| Southam Construction Ltd | Construction | 2019 |
| Southampton Bakers Limited | Manufacturing | 2015 |
| Southampton Orthodontic Centre Limited | Health & social care | 2009 |
| Southcon (Kingstone) Limited | Construction | 1996 |
| Southern (Merthyr) Limited | Wholesale & retail | 1995 |
| Southern Cross Freight Ltd. | Transport & logistics | 1992 |
| Southern Energy Connections Ltd. | Professional & scientific | 2016 |
| Southey Aylward Management Limited | Financial services | 2021 |
| Southey House Management Limited | Households | 2016 |
| Southfield Gridco Limited | Professional & scientific | 2018 |
| Southfield Limited | Financial services | 2005 |
| Southfield Manor Park Residents Association Limited | Households | 1979 |
| Southgate Court Management Company Limited | Real estate | 1988 |
| Southgate Fisheries Ltd | Hospitality | 2021 |
| Southgate Horizon Limited | Real estate | 2022 |
| Southside Boxing Ltd | Arts & recreation | 2026 |
| Southwell Management Company (Cheltenham) Limited | Real estate | 1984 |
| Southwest Microwave Limited | Administrative & support | 2002 |
| Southwest Stays Ltd | Real estate | 2025 |
| Southwest Trade Network Limited | Wholesale & retail | 2025 |
| Sovereign Asset Management Limited | Financial services | 2001 |
| Sovereign Soul Foods Ltd | Hospitality | 2026 |
| Sovereign View (Cheltenham) Management Limited | Households | 2019 |
| Sovrn UK Holdings Limited | Information & communication | 2016 |
| Sovrn UK Limited | Information & communication | 2012 |
| Sowenergy Ltd | Energy | 2012 |
| Sown Film Co Limited | Information & communication | 2023 |
| Sozo Design Limited | Information & communication | 2004 |
| SP Plumbing & Heating Ltd | Construction | 2010 |
| SP Service Ltd | Transport & logistics | 2005 |
| Sp(Resi) Ltd | Construction | 2020 |
| Spa Colour Limited | Administrative & support | 2007 |
| Spa Court Limited | Households | 1964 |
| Spa Elite Limited | Information & communication | 2009 |
| Spa Kleens Limited | Administrative & support | 2026 |
| Spa Property Solutions Limited | Construction | 2017 |
| Spa Service Appliances Limited | Wholesale & retail | 2024 |
| Spa Technology Limited | Professional & scientific | 1989 |
| Spa Trees Limited | Administrative & support | 2024 |
| Spa Vapes Ltd | Wholesale & retail | 2014 |
| Spa Villas (Cheltenham) Limited | Households | 1985 |
| Spaar Ltd | Wholesale & retail | 2024 |
| Space Cadet Brewing Company Limited | Manufacturing | 2019 |
| Space Conversions (Bristol) Ltd | Construction | 2019 |
| Space Estates Ltd | Real estate | 2024 |
| Space Modules Ltd | Real estate | 2011 |
| Space Sprogs Limited | Information & communication | 2002 |
| Space Total Security Ltd | Administrative & support | 2016 |
| Spaces Cheltenham Limited | Administrative & support | 2026 |
| Spacetech Consulting Ltd | Information & communication | 2025 |
| Spalding Wealth Management Limited | Professional & scientific | 2018 |
| Spaplas Trade Frames Ltd | Construction | 2024 |
| Spark Creative Consultants Ltd | Administrative & support | 2021 |
| Spark Evidence Ltd | Administrative & support | 2023 |
| Sparkes Home & Garden Limited | Administrative & support | 2012 |
| Sparkhouse Creatives CIC | Arts & recreation | 2025 |
| Sparky Auto Electrics Ltd | Manufacturing | 2016 |
| Sparta Property Ltd | Real estate | 2014 |
| Spartan Investments Ltd | Financial services | 2017 |
| Spartan PR Limited | Professional & scientific | 2009 |
| Spartan Properties (Cheltenham) Ltd | Real estate | 2016 |
| Spartan Rentals Ltd | Real estate | 2017 |
| Spartan Roofing & Property Maintenance Ltd | Construction | 2023 |
| Sparx Business Solutions Ltd | Information & communication | 2015 |
| SPC Consultancy Services Ltd | Professional & scientific | 2022 |
| Speaking Sport Ltd | Hospitality | 2018 |
| Special Venues Ltd | Administrative & support | 2004 |
| Specialist Cleaning and Logistical Support Ltd | Administrative & support | 2016 |
| Specialist Journeys Limited | Administrative & support | 2015 |
| Specialist Journeys Midco 1 Limited | Administrative & support | 2015 |
| Specialist Journeys Midco 2 Limited | Administrative & support | 2015 |
| Specialist Journeys Topco Limited | Professional & scientific | 2015 |
| Specialist Periodontics Limited | Health & social care | 2011 |
| Specialist Rest Dent Ltd | Health & social care | 2014 |
| Specialist Tours Limited | Administrative & support | 2013 |
| Speed Measurement Systems Limited | Administrative & support | 2014 |
| Speedchange Limited | Professional & scientific | 2018 |
| Speke Travel Limited | Administrative & support | 2021 |