| Smith Taylor Trading Ltd | Wholesale & retail | 2023 |
| Smith's Flooring Limited | Professional & scientific | 2003 |
| Smithos Ltd | Professional & scientific | 2017 |
| Smiths Rugby | Arts & recreation | 2017 |
| Smiths Scaffolding Ltd | Construction | 2022 |
| Smithvale Limited | Administrative & support | 2010 |
| Smithy's Light Haulage Limited | Transport & logistics | 2007 |
| Smnk Ltd | Real estate | 2022 |
| Smokehouse on Wheels Limited | Hospitality | 2024 |
| Smokey Joe's Cheltenham Limited | Hospitality | 2013 |
| Smokinly Good BBQ (Cotswold) Ltd | Hospitality | 2025 |
| Smoore UK Co., Ltd | Professional & scientific | 2022 |
| SMR Rauris Apartments Ltd | Households | 2021 |
| SMT Contracts Ltd | Information & communication | 2015 |
| SMT Media Ltd | Arts & recreation | 2024 |
| Smudgers Mutts Dog Grooming Limited | Other services | 2019 |
| Smudgers Mutts Ltd | Other services | 2013 |
| Smudgers Mutts Training Limited | Other services | 2022 |
| Smyth & Noble Limited | Real estate | 2011 |
| Snape Construction Limited | Construction | 1989 |
| Snape Contracting Services Ltd | Administrative & support | 2011 |
| Snape Management Solutions Limited | Real estate | 1995 |
| Snapecall (South West) Ltd | Other services | 2007 |
| Snell & Snell Ltd | Real estate | 2015 |
| Snell (Hydromotor) Limited | Professional & scientific | 2005 |
| SNH Management Limited | Households | 2003 |
| Snip Properties Limited | Real estate | 2017 |
| Snooty FOX Holdings Limited | Hospitality | 2019 |
| Snooty FOX Hotel Limited | Hospitality | 2019 |
| Snow Globe Rentals Ltd | Administrative & support | 2025 |
| Snowberry Ventures Limited | Real estate | 2012 |
| SNR Restaurants Limited | Hospitality | 2023 |
| SO Awkward Series 6 Limited | Information & communication | 2019 |
| SO Awkward Series 7 Limited | Information & communication | 2020 |
| SO Awkward Series 8 Limited | Information & communication | 2023 |
| SO Good Cleaners Ltd | Transport & logistics | 2024 |
| Soarbay Limited | Agriculture & fishing | 2023 |
| Soccer UK Tours Ltd | Education | 2019 |
| Social & Social Ltd | Professional & scientific | 2023 |
| Social Being Limited | Administrative & support | 2021 |
| Social Dance Experience Limited | Arts & recreation | 2024 |
| Social Elite Ltd | Wholesale & retail | 2018 |
| Social Energy Ltd | Professional & scientific | 2025 |
| Social Media Compliance Limited | Information & communication | 2014 |
| Social Value Together Limited | Other services | 2023 |
| Socket 3 Limited | Real estate | 2021 |
| Sofa Success Ltd | Wholesale & retail | 2016 |
| Sofas Express Ltd | Wholesale & retail | 2010 |
| Sofiaitalia Limited | Hospitality | 2026 |
| Soft Innovators (UK) Ltd | Information & communication | 2009 |
| Soft Landing Investment Portfolio Limited | Financial services | 2016 |
| Soft Practice Ltd. | Information & communication | 2012 |
| Softchains Ltd | Information & communication | 2016 |
| Softdata Internet Limited | Information & communication | 2001 |
| Software Automation International Ltd | Information & communication | 2003 |
| Soho Coffee Company Limited | Professional & scientific | 2013 |
| Soho Coffee Shops Limited | Wholesale & retail | 1999 |
| Soho Disco Limited | Arts & recreation | 2026 |
| Soho Group Holdings Limited | Financial services | 2026 |
| Soho to Go Limited | Extraterritorial | 2014 |
| Sohoaqua Limited | Professional & scientific | 2024 |
| Solace Gym Ltd | Health & social care | 2021 |
| Solar Cool Films Ltd. | Administrative & support | 2016 |
| Solaris Consensus Ltd | Information & communication | 2022 |
| Solid State Decorators Ltd | Construction | 2020 |
| Solis RN Limited | Health & social care | 2025 |
| Solo Interiors Limited | Construction | 1998 |
| Solomaids Limited | Health & social care | 2003 |
| Solu Edge Cloud Solutions Limited | Information & communication | 2023 |
| Soluna Group Limited | Administrative & support | 2026 |
| Solvewise Limited | Professional & scientific | 2019 |
| Soma Club Limited | Arts & recreation | 2025 |
| Soma Consultants Limited | Professional & scientific | 1999 |
| Somerset Arms Ltd | Hospitality | 2025 |
| Somerset Footwear Limited | Wholesale & retail | 1991 |
| Somerset House Tywyn Ltd | Hospitality | 2017 |
| Something Borrowed Flowers Ltd | Wholesale & retail | 2020 |
| Something Changed Limited | Professional & scientific | 2025 |
| Something Creatives Ltd | Hospitality | 2009 |
| Something New 5 Ltd | Construction | 2018 |
| Somnium Consulting Limited | Professional & scientific | 2013 |
| SON of a Butler Ltd | Professional & scientific | 2025 |
| Sonali Foods Ltd | Hospitality | 2005 |
| Soncho Karate Club Community Interest Company | Education | 2023 |
| Sonder & Lime Ltd | Arts & recreation | 2021 |
| Sonicular Ltd | Information & communication | 2022 |
| Sonny and Bintou Services Limited | Hospitality | 2015 |
| Sonq Music Ltd | Information & communication | 2025 |
| SOPERIPERI2 Ltd | Hospitality | 2022 |
| Sopers Holdings Ltd. | Financial services | 2021 |
| Sophie Hodges Studio Limited | Professional & scientific | 2016 |
| Sophie Mutevelian Limited | Professional & scientific | 2015 |
| Sophie Norton Consulting Limited | Education | 2005 |
| Sophie Reid Limited | Manufacturing | 2022 |
| Sora GRP Ltd | Information & communication | 2026 |
| Sorrel Management Services Limited | Professional & scientific | 1998 |
| Sorrel Stores Limited | Real estate | 2023 |
| Sota Design Ltd | Professional & scientific | 2019 |
| Soul and Stride Ltd | Health & social care | 2024 |
| Soul Flow Energy Limited | Real estate | 2023 |