| Sjelectrical Services (SW) Ltd | Professional & scientific | 2023 |
| SJK Private Ltd | Health & social care | 2021 |
| SJM Financial Planning Ltd | Professional & scientific | 2021 |
| SJM Health & Home Support Services Ltd | Health & social care | 2021 |
| SJM Investments Limited | Financial services | 2018 |
| SJM Properties (Amberley) Limited | Real estate | 2016 |
| SJR Media Ltd | Information & communication | 2023 |
| SJT Corporate Finance Ltd | Financial services | 2017 |
| SJW Renovations Limited | Construction | 2025 |
| SK Kirisham Ltd | Wholesale & retail | 2019 |
| Skaithmuir | Financial services | 2018 |
| Skate Properties Ltd | Real estate | 2020 |
| Skate Services Limited | Manufacturing | 2021 |
| Skelian Healthcare Limited | Health & social care | 2018 |
| Skern's Reach Limited | Professional & scientific | 2024 |
| SKG Capital GP Limited | Financial services | 2020 |
| Skilicorn Holdings Limited | Hospitality | 2018 |
| Skin by Courtney Melody Ltd | Other services | 2021 |
| Skin Freaks Limited | Wholesale & retail | 2019 |
| Skin Matters (Bristol) Limited | Wholesale & retail | 2008 |
| Skin Redefined Ltd | Other services | 2023 |
| Skin-Perfection (SW) Limited | Other services | 2019 |
| Skindazed Ltd | Wholesale & retail | 2025 |
| Skiptree Management Limited | Education | 2005 |
| Skipworth Limited | Construction | 2023 |
| SKN Deep Academy Ltd | Education | 2023 |
| Skotkonung Development Ltd. | Information & communication | 2012 |
| Skotkonung Ltd | Information & communication | 2011 |
| SKS Software Limited | Administrative & support | 2016 |
| Sky 7 Productions Ltd | Information & communication | 2011 |
| Sky Rocket Media Limited | Professional & scientific | 2010 |
| Sky Tech Studio Limited | Wholesale & retail | 2023 |
| Skyborne Aviation Group Limited | Financial services | 2020 |
| Skyborne Aviation Training Limited | Education | 2017 |
| Skybridge Accounting Limited | Professional & scientific | 2001 |
| Skylark Agency Ltd | Professional & scientific | 2017 |
| Skylark and Hare Ltd. | Construction | 2015 |
| Skylark Bathrooms Ltd | Construction | 2023 |
| Skyline Systems Limited | Wholesale & retail | 1988 |
| Skynetics Ltd | Professional & scientific | 2012 |
| Skytime Aviation Group Limited | Professional & scientific | 2017 |
| Skytime Jets Limited | Transport & logistics | 2012 |
| Skyward Kids Limited | Education | 2022 |
| Slab Holdings Ltd | Real estate | 2026 |
| Slad Farm Lettings Limited | Real estate | 2021 |
| Slam Consultants Limited | Information & communication | 2005 |
| SLB Introductions Limited | Other services | 2023 |
| Sleep Evolution Ltd | Manufacturing | 2016 |
| Sleeping Rhino Ltd | Real estate | 2020 |
| SLG Allstars Limited | Financial services | 2014 |
| SLG Brands Limited | Wholesale & retail | 1985 |
| Slide Ltd | Financial services | 2024 |
| Slide Supply Ltd | Wholesale & retail | 2025 |
| Slipstream Organics Limited | Wholesale & retail | 2005 |
| SLJ Power Ltd | Professional & scientific | 2008 |
| SLM Plastic Engineering Limited | Financial services | 2008 |
| SLM Professional Services Limited | Health & social care | 2021 |
| SLO Coffee Ltd | Manufacturing | 2024 |
| Sloanes Cheltenham Limited | Other services | 2020 |
| Slow Space Ltd | Real estate | 2021 |
| SM Energy Consulting Limited | Professional & scientific | 2022 |
| SMA Sporting Ltd | Arts & recreation | 2021 |
| Small Car Company (Sales) Limited | Wholesale & retail | 2002 |
| Small Claims Assistance Ltd | Professional & scientific | 2018 |
| Small DOT Ltd | Professional & scientific | 2019 |
| Smart Accommodation Ltd | Hospitality | 2020 |
| Smart Car Care Ltd | Wholesale & retail | 2025 |
| Smart Computers Limited | Wholesale & retail | 1996 |
| Smart Dental Group Limited | Health & social care | 2023 |
| Smart Energy Meters Limited | Professional & scientific | 2009 |
| Smart Group Property Ltd | Real estate | 2020 |
| Smart Health Science Limited | Professional & scientific | 2013 |
| Smart Home Solutions Ltd | Information & communication | 2010 |
| Smart Home Sounds Ltd | Information & communication | 2013 |
| Smart Link Investments Limited | Real estate | 2006 |
| Smart Medical Limited | Wholesale & retail | 2002 |
| Smart Notebooks Limited | Information & communication | 2008 |
| Smart Pool Services Ltd | Administrative & support | 2018 |
| Smart Product Development Limited | Professional & scientific | 2023 |
| Smarter Knowledge Exchange Ltd. | Information & communication | 2019 |
| Smartest Solutions Ltd | Professional & scientific | 2018 |
| Smartinsight Advisory Limited | Professional & scientific | 2025 |
| Smartstone Masons Limited | Manufacturing | 2014 |
| Smash Three (Cheltenham) Limited | Hospitality | 2019 |
| Smashing Foods Ltd | Hospitality | 2009 |
| Smdt Limited | Education | 2019 |
| Smews Ltd. | Real estate | 2023 |
| Smile Bryte Limited | Health & social care | 2008 |
| Smile Excellence Limited | Health & social care | 2016 |
| Smile for Better Health Ltd | Health & social care | 2018 |
| Smile for Life Limited | Health & social care | 2006 |
| Smile Horizons Limited | Health & social care | 2008 |
| Smile Media Limited | Information & communication | 2021 |
| Smile Solution Limited | Health & social care | 2009 |
| Smith & Swepson Opticians Limited | Health & social care | 2007 |
| Smith Heath Holdings Limited | Financial services | 2017 |
| Smith Heath Limited | Professional & scientific | 2004 |
| Smith Hotchen Partnership Limited | Professional & scientific | 2014 |
| Smith Investments (Cheltenham) Limited | Real estate | 1987 |
| Smith Russell (Management) Limited | Professional & scientific | 1997 |