| S3 Design Ltd | Professional & scientific | 2002 |
| SA Childcare Limited | Education | 2006 |
| Sa.Gold Ltd | Arts & recreation | 2021 |
| Sabai Thai Massage Ltd | Other services | 2023 |
| Sabayon Ltd | Extraterritorial | 2023 |
| Sabre Electrical Ltd | Construction | 2021 |
| Sacred Butterflies Limited | Manufacturing | 1996 |
| Sacu Limited | Education | 2013 |
| Saddleworth Nursery Ltd | Education | 2013 |
| Sadiq Wilkes Legal Limited | Professional & scientific | 2017 |
| SAE Health Care Solutions Limited | Financial services | 2020 |
| SAF Food Ltd | Hospitality | 2024 |
| Safe Environmental Solutions (Worldwide) Ltd | Professional & scientific | 2023 |
| Safe Hands Childcare (UK) Limited | Education | 2013 |
| Safe Hosts Internet LLP | | 2004 |
| Safe Smile Implants Ltd | Health & social care | 2025 |
| Safe Sustainable World Ltd | Information & communication | 2025 |
| Safeagent CMP Limited | Other services | 2019 |
| Safehands Complex Care Ltd | Administrative & support | 2023 |
| Safehands Recruitment Franchise Limited | Administrative & support | 2018 |
| Safehands Recruitment Ltd | Administrative & support | 2013 |
| Safenet Groups Ltd | Education | 2022 |
| Safer Independence Ltd | Information & communication | 2023 |
| Safety Hands Plus Limited | Professional & scientific | 2023 |
| Saffa Cooling Ltd | Professional & scientific | 2023 |
| Saffron Cuisine London Ltd | Hospitality | 2026 |
| Saffron Hill Interim Limited | Administrative & support | 2021 |
| Saffron Lounge Evesham Ltd | Hospitality | 2019 |
| Saffron Lounge Sakri Ltd | Hospitality | 2024 |
| SAFFRON22 Limited | Professional & scientific | 2021 |
| Saffronpea Ltd | Professional & scientific | 2015 |
| Safhg Limited | Extraterritorial | 2021 |
| Sahi Bazar Ltd | Wholesale & retail | 2023 |
| SAI Computers Limited | Information & communication | 2007 |
| Said Capital Partners Limited | Administrative & support | 2018 |
| Sailing Holidays Group Finance Limited | Financial services | 2024 |
| Sailpoint Technologies UK Ltd | Professional & scientific | 2008 |
| Saints Hardware Limited | Wholesale & retail | 2010 |
| Saitch Associates Limited | Professional & scientific | 1998 |
| Sakura Sings | Financial services | 2024 |
| Sakura Teahouse Ltd | Hospitality | 2024 |
| SAL Heavy Lift UK Limited | Transport & logistics | 2012 |
| Saldavian Court RTM Limited | Households | 2007 |
| Saldons Farm Solar Limited | Energy | 2023 |
| Salecreate Limited | Construction | 1999 |
| Sales Engine Tuning Limited | Professional & scientific | 2022 |
| Sales-I Badger Limited | Professional & scientific | 2008 |
| Sales-I Limited | Information & communication | 2018 |
| Salmon Swimming Ltd | Professional & scientific | 2021 |
| Salon Essentials Limited | Professional & scientific | 1997 |
| Salt Bakehouse Ltd | Wholesale & retail | 2016 |
| Salt Estates Limited | Real estate | 2025 |
| Salt Waters Trading Ltd | Wholesale & retail | 2013 |
| Salt Way Farm Bess Limited | Energy | 2022 |
| Salter Cyclones Limited | Professional & scientific | 2011 |
| Salterley Grange Apartments Management Company Limited | Households | 2004 |
| Salterley Management Company Limited | Households | 1978 |
| Salterley Properties LLP | | 2024 |
| Salto Labs UK Limited | Information & communication | 2023 |
| Saltway Property Limited | Real estate | 2026 |
| Saltwic Country Consulting Ltd | Professional & scientific | 2026 |
| Saltwic Country Dogs Limited | Agriculture & fishing | 2024 |
| Salubritas Consulting Ltd | Education | 2024 |
| Salvortech Limited | Professional & scientific | 2023 |
| SAM Accountants EN Adviseurs LLP | | 2014 |
| SAM Forrest Public Relations Limited | Professional & scientific | 2000 |
| SAM Pilcher Limited | Wholesale & retail | 2016 |
| SAM RAY Property Limited | Real estate | 2007 |
| SAM Wharton Heating Services Ltd | Construction | 2013 |
| Samba TV UK Limited | Information & communication | 2016 |
| Sami Software Limited | Information & communication | 2023 |
| Samiatha Ltd | Real estate | 2019 |
| Samopoly Ltd | Real estate | 2018 |
| Sampson Technology Ltd | Administrative & support | 2020 |
| Samrub Thai Ltd | Hospitality | 2023 |
| Sams Breakfast Van Ltd | Hospitality | 2026 |
| Samuel King & Company Limited | Extraterritorial | 2010 |
| SAN Services Ltd | Wholesale & retail | 2021 |
| Sanbach LLP | | 2024 |
| Sanco UK Ltd | Administrative & support | 2005 |
| Sanctuary Retreats Limited | Professional & scientific | 2001 |
| Sand Visuals Studio Ltd | Information & communication | 2020 |
| Sandcastles Nursery Limited | Education | 2000 |
| Sandford Aerospace and Business Services Limited | Professional & scientific | 2018 |
| Sandford Analytics Advisory Limited | Professional & scientific | 2026 |
| Sandford Gate Group Ltd | Construction | 2025 |
| Sandford Gate Homes Limited | Construction | 2010 |
| Sandford Park House Management Ltd | Households | 2024 |
| Sandford Park Residents Association Limited | Households | 1975 |
| Sandford Park Villa Management Limited | Households | 2001 |
| Sandie PAR Limited | Professional & scientific | 2022 |
| Sandown Park Limited | Professional & scientific | 1885 |
| Sandra's Food Kitchen Ltd | Hospitality | 2025 |
| Sandringham Court (Cheltenham) Limited | Households | 2009 |
| Sandywell Andoversford Management Limited | Households | 1999 |
| Sangamo Therapeutics UK Ltd | Administrative & support | 1999 |
| Sanghera Boyal Properties Ltd | Real estate | 2024 |
| Sangster Consulting Limited | Professional & scientific | 2018 |
| Sanisa Kitchens Ltd | Hospitality | 2026 |
| Sanitary Salvage Limited | Wholesale & retail | 2019 |