| Roxant Property Limited | Real estate | 2021 |
| Roxy Developments Ltd | Construction | 2015 |
| Royle Mews Management Company Ltd | Households | 2014 |
| Royston Cheltenham (Residents Association) Limited | Households | 1975 |
| Royys Limited | Wholesale & retail | 2014 |
| Roza Nominees Limited | Professional & scientific | 2014 |
| Rozard Limited | Professional & scientific | 2021 |
| RP Business Operations Ltd | Professional & scientific | 2025 |
| RP Driving Solutions Ltd | Administrative & support | 2022 |
| Rpmc Consulting Limited | Professional & scientific | 2012 |
| RPR Advisory Ltd | Professional & scientific | 2015 |
| RRA Architects Ltd | Professional & scientific | 2011 |
| RRM (Chelt) Investment Ltd | Real estate | 2019 |
| RS 2020 Property Limited | Real estate | 2020 |
| RS Cladding & Roofing Limited | Construction | 2015 |
| RS Developments (Berks) Ltd | Real estate | 2007 |
| RS Property (Berks) Limited | Real estate | 2015 |
| Rsee Property Ltd | Real estate | 2017 |
| Rsjm Ltd | Real estate | 2022 |
| RSM Software Consulting Ltd | Information & communication | 2014 |
| RSN Retail Ltd | Wholesale & retail | 2020 |
| RSN Stow Limited | Agriculture & fishing | 2016 |
| Rsta Enterprise UK Ltd | Hospitality | 2022 |
| RTA Restoration Ltd | Professional & scientific | 2023 |
| RTO Pictures Limited | Information & communication | 1990 |
| RTW Transport Services Limited | Transport & logistics | 2013 |
| Ruby and LU Ltd | Hospitality | 2022 |
| Ruby Dragonfly Ltd | Financial services | 2025 |
| Ruby Tools Limited | Wholesale & retail | 2024 |
| Rudolf Steiner Book Trust | Wholesale & retail | 1988 |
| Rudra Caterers PVT Ltd | Hospitality | 2025 |
| Rule Five Limited | Information & communication | 2012 |
| Run IT Solutions Limited | Construction | 2006 |
| Run the Race Ltd | Real estate | 2019 |
| Run Your Business Online Limited | Information & communication | 2013 |
| Rune Martial Arts CIC | Arts & recreation | 2026 |
| Runnerz Cleaning & Maintenance Ltd | Administrative & support | 2024 |
| Runwithian Limited | Education | 2026 |
| Rupert Jack Limited | Professional & scientific | 2018 |
| Rush Technology Limited | Information & communication | 2015 |
| Rushbury Recreation Limited | Hospitality | 2025 |
| Russell Family Group Ltd | Administrative & support | 2019 |
| Russell Lloyd Developments Limited | Construction | 2013 |
| Russell Telecom Systems Limited | Information & communication | 1990 |
| Rusticana Court Management Limited | Real estate | 2016 |
| Rutland Court (Cheltenham) Limited | Households | 1967 |
| Rutter Surveying Limited | Construction | 2008 |
| Ruya Recruitment Ltd | Administrative & support | 2021 |
| Rvin Limited | Health & social care | 2025 |
| RVW Residential Ltd | Real estate | 2024 |
| Rwhartop Limited | Construction | 2020 |
| Rwhartop Renewables Ltd | Extraterritorial | 2022 |
| RWT Holdings Limited | Financial services | 2023 |
| Rydal Art and Design Ltd | Wholesale & retail | 2026 |
| Ryefield 77 Ltd | Real estate | 2025 |
| Ryeworth Investments Limited | | 1960 |
| Ryhall Coaching and Consultancy Ltd | Administrative & support | 2022 |
| Ryro Plumbing & Heating Limited | Construction | 2024 |
| Ryzenz Limited | Wholesale & retail | 2023 |
| Résumé Projects UK Ltd | Wholesale & retail | 2019 |
| S & J Properties (Cheltenham) Ltd | Real estate | 2024 |
| S & J Reclamation and Roofing Suppliers Limited | Wholesale & retail | 2017 |
| S & J Training Limited | Real estate | 2017 |
| S a Mann Limited | Professional & scientific | 2025 |
| S B N Group Limited | Professional & scientific | 2023 |
| S Duncan Properties Ltd | Real estate | 2020 |
| S G Fencing Limited | Construction | 2010 |
| S Gilder Electrical Limited | Construction | 2024 |
| S H King Ltd | Construction | 2003 |
| S Hughes PCS Ltd | Professional & scientific | 2025 |
| S J Ayres Builders Limited | Construction | 2009 |
| S J Johnson Associates Limited | Construction | 2009 |
| S J Secretarial Limited | Administrative & support | 2016 |
| S Jeffreys Plumbing and Heating Limited | Construction | 2019 |
| S P Handcock & Sons Limited | Construction | 2008 |
| S R & H E Tushingham Limited | Professional & scientific | 2008 |
| S Rodrigues Ltd | Professional & scientific | 2022 |
| S V Pierini Property Ltd | Real estate | 2018 |
| S&A Flooring Trading Limited | Wholesale & retail | 2026 |
| S&A Furniture Trading Limited | Wholesale & retail | 2005 |
| S&Ed Corporation Ltd | Hospitality | 2025 |
| S&Kb Properties Ltd | Real estate | 2020 |
| S&N Aesthetics Clinics Ltd | Health & social care | 2019 |
| S&N Restaurants Limited | Hospitality | 2023 |
| S&S Shalli Limited | Real estate | 2020 |
| S-D Treecare Limited | Agriculture & fishing | 1999 |
| S. a. Boyd International Limited | Wholesale & retail | 2015 |
| S. I. Partnership Limited | Professional & scientific | 2008 |
| S. L. R. Coaching Limited | Education | 2002 |
| S. Wilkinson HR Consulting Ltd | Administrative & support | 2017 |
| S.E. Marsh & SON Limited | Agriculture & fishing | 1961 |
| S.Healing(Confectionery)Limited | Real estate | 1948 |
| S.L.M. (Model) Engineers Limited | Manufacturing | 1969 |
| S.P. Hughes (Electrical) Limited | Construction | 2005 |
| S.T. International Tourist Agency LLP | | 2006 |
| S.V. Pierini & Co Limited | Health & social care | 2007 |
| S.W. Landscapes and Roofing Limited | Construction | 2024 |
| S.W.K.M Properties Ltd | Real estate | 2026 |
| S19 Beauty and Aesthetics Limited | Other services | 2018 |
| S2 Services Limited | Professional & scientific | 2025 |