| Santana 61 Limited | Extraterritorial | 2013 |
| Santana Apartments Ltd | Real estate | 2021 |
| SAP Property Group Limited | Real estate | 2025 |
| Sapafy Ltd | Information & communication | 2024 |
| Sapper Drummond Limited | Professional & scientific | 2007 |
| Sapphire Coffee Ltd | Hospitality | 2024 |
| Sapphire Falls Limited | Real estate | 2021 |
| Sapphire Projects & Collections Ltd | Real estate | 2019 |
| Sara Catering Ltd | Hospitality | 2026 |
| Saracen Care Partners LLP | | 2013 |
| Saracen Care Services Limited | Health & social care | 2004 |
| Saracen Property Limited | Real estate | 2018 |
| Sarah Hawkins Hair Ltd | Administrative & support | 2017 |
| Sarah Henry Ltd | Administrative & support | 2019 |
| Sarah Pratap Oncology Limited | Health & social care | 2025 |
| Sarahcox.Tv Ltd | Information & communication | 2024 |
| Saran UK Limited | Hospitality | 1997 |
| Sarco Limited | Professional & scientific | 1970 |
| Sarco Thermostats Limited | Professional & scientific | 1937 |
| Sardar Cafe Ltd | Hospitality | 2025 |
| Sarniamedicines Limited | Professional & scientific | 2016 |
| Sassy Spaces Ltd | Professional & scientific | 2026 |
| Satisfaction Fulfilled Limited | Arts & recreation | 1992 |
| Satnam Car Parking Limited | Transport & logistics | 1986 |
| Satnam Developments Limited | Real estate | 1995 |
| Satnam Investments Limited | Construction | 1981 |
| Satnam Limited | Real estate | 1984 |
| Satnam Parking Limited | Transport & logistics | 1991 |
| Satnam Planning Services Limited | Professional & scientific | 1995 |
| Satnam Urban Regeneration Limited | Transport & logistics | 1984 |
| Saturday Auction Ltd | Professional & scientific | 2024 |
| Saul Junction Boatowners Club Limited | Other services | 1988 |
| Saunders Extreme Sports Limited | Wholesale & retail | 2004 |
| Savage Selection Limited | Wholesale & retail | 1988 |
| Save Hire Limited | Arts & recreation | 2023 |
| Save OUR Green at Westdown Ltd | Extraterritorial | 2021 |
| Savita's Food Ltd | Hospitality | 2023 |
| Savoy's Dining Ltd | Hospitality | 2025 |
| SAX Property Limited | Real estate | 2022 |
| Saxon Print Ltd | Manufacturing | 2016 |
| Saxon Properties Cheltenham Ltd | Extraterritorial | 2025 |
| Saxthorpe Berkeley Street Cheltenham Residents Company Limited | Households | 1985 |
| SAY IT NOW Ltd | Information & communication | 2018 |
| SB Business Consulting Limited | Professional & scientific | 2018 |
| SBA Developments Limited | Construction | 2015 |
| Sbchb Ltd | Information & communication | 2014 |
| SBH Willersey Ltd | Construction | 2018 |
| SBM Resources Limited | Manufacturing | 2003 |
| Sbrown Property Limited | Manufacturing | 2026 |
| SBS Management Consultants Limited | Professional & scientific | 2018 |
| SBS Solutions and Services Limited | Information & communication | 2024 |
| SC Accounts Ltd | Professional & scientific | 2024 |
| SC Auto Services Ltd | Wholesale & retail | 2025 |
| Scahill Ltd | Wholesale & retail | 2019 |
| Scale GEN AI Ltd | Information & communication | 2025 |
| Scantleton Limited | Financial services | 1978 |
| SCB Medical Ltd | Health & social care | 2025 |
| Scholar & Sage Ltd | Education | 2022 |
| Scholar's Table Limited | Wholesale & retail | 2010 |
| School of Natural Medicine Ltd | Education | 2021 |
| School Requirement Solutions Limited | Education | 2015 |
| Schoolzone.Co.Uk Limited | Professional & scientific | 1998 |
| Science Outreach Limited | Information & communication | 2026 |
| Sciontec Limited | Professional & scientific | 1996 |
| Sciro Group Limited | Information & communication | 2016 |
| Sclc Properties Ltd | Real estate | 2025 |
| Scope Cheltenham Ltd | Real estate | 2014 |
| Scorch Transport Limited | Transport & logistics | 2019 |
| Scoriton Limited | Households | 1985 |
| Scorpion International UK Limited | Information & communication | 2009 |
| Scotia GAS Limited | Administrative & support | 2012 |
| Scotia Limited | Construction | 1979 |
| Scott Arms Associates Limited | Health & social care | 2010 |
| Scott Reynolds Search Partners LLP | | 2009 |
| SCOTT3MEDIA Limited | Manufacturing | 2020 |
| Scran DOH Ltd | Hospitality | 2024 |
| Scriptura Limited | Professional & scientific | 2000 |
| SCS (South) Limited | Administrative & support | 2019 |
| Scts Consulting Limited | Construction | 2025 |
| Sculpted by Ariella Ltd | Other services | 2024 |
| SD Caterers PVT Ltd | Hospitality | 2024 |
| SD Dentco Limited | Health & social care | 2015 |
| SD Plastering Services Ltd | Construction | 2022 |
| SD Training UK Limited | Administrative & support | 2024 |
| SD World Ltd | Wholesale & retail | 2019 |
| SDG Engineering Limited | Professional & scientific | 2009 |
| SDM Maritime Limited | Professional & scientific | 2022 |
| Sdsp Ltd | Health & social care | 2025 |
| SE Engineering Consultancy Limited | Information & communication | 2016 |
| Sea Caves Investments Ltd | Financial services | 2017 |
| Sea Charge Limited | Professional & scientific | 2024 |
| Seaborne Leisure Limited | Hospitality | 1988 |
| Seabrook Audiology Limited | Health & social care | 2014 |
| Seaforest Property Limited | Real estate | 2022 |
| Seaforth International Limited | Financial services | 1999 |
| Seagrass Holdings Limited | Financial services | 2017 |
| Seagrave Villas Management Company Limited | Households | 1996 |
| Seahorse & Swan Limited | Real estate | 2017 |
| Seahorse Advisors Limited | Professional & scientific | 2021 |
| Seahorse Capital Unlimited | Financial services | 2021 |