| Sahafuel Ltd | Wholesale & retail | 2020 |
| Saherwala and Sons Ltd | Health & social care | 2014 |
| Sahlj LLP | | 2017 |
| Saifkhan Limited | Health & social care | 2026 |
| Sailnstay Limited | Administrative & support | 2024 |
| Saint Johnpaul & Co Ltd | Health & social care | 2016 |
| Saipro Ltd | Health & social care | 2016 |
| Sajjan Construction Ltd | Real estate | 2022 |
| Sakhi Associates Ltd | Wholesale & retail | 2022 |
| Sales Star UK Limited | Professional & scientific | 2023 |
| Salimian Properties Ltd | Real estate | 2025 |
| Salimsons Ltd | Wholesale & retail | 2023 |
| Salma Grill Co Limited | Hospitality | 2017 |
| Salmons of Ulverston Ltd | Wholesale & retail | 2018 |
| Salon Furniture NW Ltd | Wholesale & retail | 2020 |
| Salt Catering Kitchen Ltd | Hospitality | 2026 |
| Salthill Training and Consulting Limited | Professional & scientific | 2025 |
| SAM Care Limited | Health & social care | 2019 |
| SAMA89 Ltd | Health & social care | 2023 |
| Sambhav Management Limited | Professional & scientific | 2012 |
| Same Level Limited | Real estate | 2018 |
| Sammark Properties Limited | Real estate | 2012 |
| Samoo Construction Ltd | Construction | 2025 |
| Samsan Homes Limited | Real estate | 2024 |
| Samtif Ventures Limited | Wholesale & retail | 2026 |
| Samuelklocum Ltd | Wholesale & retail | 2022 |
| Sam’S Paving Company Ltd | Administrative & support | 2025 |
| San-It Limited | Information & communication | 2008 |
| Sanaceutics Limited | Wholesale & retail | 2023 |
| Sandtoft Roof Tiles Limited | Extraterritorial | 1990 |
| Sandton Investments Limited | Financial services | 2005 |
| Sanja Ltd | Administrative & support | 2024 |
| Santony Management Limited | Real estate | 2013 |
| Sapori Cheadle Limited | Hospitality | 2024 |
| Sapphire Avenues Ltd | Construction | 2020 |
| Sapphire Clothing Ltd | Wholesale & retail | 2015 |
| SAR Manchester Ltd | Health & social care | 2024 |
| Sarah Segree Ltd | Health & social care | 2023 |
| Saravana Consultants Limited | Health & social care | 2015 |
| Sardar Family Property Partnership LLP | | 2020 |
| Sarwar Medical Imaging Ltd | Health & social care | 2012 |
| SAS Flooring Ltd | Construction | 2008 |
| SAS Healthcare Limited | Wholesale & retail | 2012 |
| Sash Property Limited | Real estate | 2020 |
| Sash Window Solutions Services Ltd | Construction | 2026 |
| Satya Medical Limited | Health & social care | 2015 |
| Saum Medical Limited | Health & social care | 2024 |
| Savi Holdings Ltd | Real estate | 2020 |
| Sawaiz Ltd | Wholesale & retail | 2021 |
| Sawer Property Company Limited | Administrative & support | 2016 |
| Sayaz Ltd | Wholesale & retail | 2024 |
| SAZ Media Club Limited | Information & communication | 2017 |
| SB & Pikko Company Limited | Real estate | 2025 |
| SB Homecare Services Limited | Health & social care | 2022 |
| SB19 Corporate Advisors Ltd | Professional & scientific | 2023 |
| SB19 Group Ltd | Real estate | 2025 |
| SB19 Property Ltd | Real estate | 2025 |
| Sblw Holding Ltd | Information & communication | 2025 |
| SBP Associates Limited | Education | 2017 |
| SBR CA Ltd | Professional & scientific | 2025 |
| SBR Capital Ltd | Real estate | 2026 |
| SC Technical Ltd | Manufacturing | 2025 |
| SCC Consultants Ltd | Construction | 2023 |
| Scgunn GAS Ltd | Construction | 2017 |
| SCH50 Limited | Financial services | 2026 |
| Schilling Catering Co. Ltd | Hospitality | 2022 |
| School Court Management Limited | Households | 1993 |
| Scienta Limited | Professional & scientific | 1999 |
| Scienta Systems Limited | Professional & scientific | 1998 |
| Scissor CUT Barber Limited | Other services | 2017 |
| SCL Property Group Ltd | Real estate | 2016 |
| Scooter Pimps Limited | Wholesale & retail | 2022 |
| Scope 3 Ltd | Information & communication | 2021 |
| Scoreboard Insights Limited | Information & communication | 2026 |
| Scott Property Consultants (North West) Limited | Real estate | 2021 |
| Scottsway Ltd | Hospitality | 2018 |
| Scranchester Ltd | Extraterritorial | 2022 |
| Scratch Matchplay Limited | Arts & recreation | 2025 |
| Scriptwise-Uk Limited | Wholesale & retail | 2019 |
| Scrowther Enterprise Ltd | Professional & scientific | 2013 |
| SCS Motor Group Ltd | Wholesale & retail | 2023 |
| Sculptor Holdings Limited | Real estate | 2021 |
| SD Legal Ltd | Professional & scientific | 2026 |
| SD Roofing Ltd | Construction | 2026 |
| SD Talent Management Ltd | Professional & scientific | 2019 |
| Sdjo Ltd | Hospitality | 2025 |
| Sdka Capital 1 Ltd | Financial services | 2019 |
| Sdka Ltd | Financial services | 2016 |
| SDL Properties Limited | Real estate | 2006 |
| SE Structural Engineering Limited | Professional & scientific | 2019 |
| Search the Dentist Ltd | Health & social care | 2025 |
| Secret Sky Ltd | Hospitality | 2024 |
| Secure and Protect Solutions Ltd | Administrative & support | 2018 |
| Secure Glazing Limited | Construction | 2010 |
| Security Courses Near ME Ltd | Education | 2025 |
| Security Services Group Limited | Administrative & support | 2021 |
| Sedat Hairdressing Limited | Other services | 2020 |
| Sedo Fast Food Ltd | Hospitality | 2022 |
| SEE Beyond CIC | Hospitality | 2026 |
| SEE Clear Vision Ltd | Wholesale & retail | 2021 |