| Sefton Park Townhouse Ltd | Hospitality | 2019 |
| Segura Consulting Limited | Professional & scientific | 2020 |
| Selco Holdings Ltd | Financial services | 2026 |
| Selco Homes Ltd | Real estate | 2026 |
| Select Network Services Limited | Other services | 2009 |
| Selfstore Group Ltd | Real estate | 2018 |
| Selfstore(Uk) Ltd | Professional & scientific | 2018 |
| Seller Manch Ltd | Wholesale & retail | 2022 |
| Semovo Holdings Limited | Financial services | 2020 |
| Semovo Limited | Health & social care | 2016 |
| Sensei Property Investments Limited | Real estate | 2021 |
| Sensilis Ltd | Real estate | 2016 |
| Sensorywise Bramhall Ltd | Health & social care | 2023 |
| Sentura Ltd | Administrative & support | 2025 |
| Sepi Refrigerants Ltd | Wholesale & retail | 2018 |
| Sequel Accounting Ltd | Professional & scientific | 1937 |
| SER Building Materials Ltd | Wholesale & retail | 2019 |
| Serac Properties Ltd | Real estate | 2020 |
| Serawave Care Ltd | Health & social care | 2026 |
| Serene Smiles Ltd | Health & social care | 2025 |
| Serenity Developments Ltd | Construction | 2020 |
| Serenity Developments ML Limited | Construction | 2022 |
| Services Design Partnership Limited | Professional & scientific | 1987 |
| Servico the Service Company Limited | Real estate | 2012 |
| Servotech EOT Limited | Professional & scientific | 2025 |
| Sesega Data Solutions Ltd | Professional & scientific | 2018 |
| Seta Partners Ltd | Wholesale & retail | 2019 |
| Sethi Solutions Limited | Information & communication | 2016 |
| Settside Projects Limited | Real estate | 2004 |
| Seven Drunken Nights Touring Limited | Arts & recreation | 2024 |
| Severe Weather Updates VW Ltd | Information & communication | 2025 |
| SF Consultant Ltd | Professional & scientific | 2020 |
| SF Medical Services UK Limited | Health & social care | 2010 |
| SF Radiology Limited | Health & social care | 2023 |
| SFM Management Limited | Professional & scientific | 2022 |
| SFO Investments (X01) Ltd | Financial services | 2024 |
| SFO Investments Ltd | Financial services | 2024 |
| SG Measurement Limited | Wholesale & retail | 2016 |
| SGF Properties Limited | Real estate | 2017 |
| SGJ Consultants Ltd | Health & social care | 2016 |
| Sgul Infinite Limited | Health & social care | 2023 |
| SH Bussiness Limited | Hospitality | 2026 |
| SH479 Ltd | Health & social care | 2017 |
| Shabaz Whitefield Limited | Hospitality | 2018 |
| Shafi Enterprises Ltd | Health & social care | 2025 |
| Shafi Real Estate Limited | Real estate | 2025 |
| Shaftesbury Property Managment Services Ltd | Real estate | 2025 |
| Shajafri Ltd | Real estate | 2026 |
| Shakedown Resturants Ltd | Hospitality | 2026 |
| Shamsm Ltd | Health & social care | 2021 |
| Shan Traders (UK) Ltd | Information & communication | 2020 |
| Shan&Sach Limited | Real estate | 2018 |
| Shana Keeler's School of Dance & Performing Ltd | Education | 2025 |
| Shared Ownership Limited | Financial services | 2007 |
| Sharp.Works Limited | Information & communication | 2015 |
| Sharqawi Limited | Health & social care | 2022 |
| Shatahisha Ltd | Real estate | 2016 |
| Shaun Mccarthy Trading Limited | Administrative & support | 2024 |
| SHE Talks CIC | Education | 2024 |
| Sheald Ltd | Information & communication | 2015 |
| Shepherd Private Clients Limited | Professional & scientific | 2017 |
| Shepherd Trustees Limited | Professional & scientific | 2019 |
| Sherann Hillman Send Consultancy Ltd | Professional & scientific | 2026 |
| Sherratt Property Ltd | Real estate | 2026 |
| SHF Catering Ltd | Hospitality | 2016 |
| Shifu Consulting Limited | Information & communication | 2019 |
| Shimla Enterprises Limited | Wholesale & retail | 2016 |
| Shine Time Mobile Detailing Ltd | Administrative & support | 2025 |
| Shirles Limited | Professional & scientific | 2014 |
| Shivaaz Limited | Information & communication | 2011 |
| Shmart Studio Ltd | Information & communication | 2025 |
| SHO Holdings Limited | Financial services | 2025 |
| Shoot Business Ltd | Information & communication | 2015 |
| Shopiit Limited | Wholesale & retail | 2023 |
| Short Construction Limited | Construction | 2010 |
| SHP LEE Ltd | Wholesale & retail | 2023 |
| Shree Gururaj Trading Ltd | Transport & logistics | 2026 |
| Shreena Healthcare Limited | Health & social care | 2019 |
| Shri Sampada Private Limited | Real estate | 2019 |
| Shuk Beauty Ltd | Wholesale & retail | 2019 |
| SIA Pharma Ltd | Wholesale & retail | 2024 |
| Siaf Holding Ltd | Financial services | 2019 |
| SID IT Solution Limited | Information & communication | 2018 |
| Siddiqui Wardle Orthotics Ltd | Wholesale & retail | 2021 |
| Sidney Paul & Co Ltd | Professional & scientific | 2002 |
| Sign & Display Limited | Manufacturing | 2009 |
| Silk Homes Limited | Real estate | 2024 |
| Silver Falcon Development Ltd | Construction | 2026 |
| Silver Lane Group Ltd | Other services | 2020 |
| Silver Lining Document Storage Limited | Professional & scientific | 2003 |
| Silver Pagoda Realty Group Ltd | Real estate | 2017 |
| Silver Pearl Limited | Health & social care | 2023 |
| Silverdale Property Ltd | Construction | 2024 |
| Silverwood Didsbury Management Limited | Real estate | 2020 |
| Simms Apex Commerce Ltd | Wholesale & retail | 2026 |
| Simon Daniel Properties Limited | Real estate | 2023 |
| SIMON-8 Limited | Manufacturing | 2021 |
| Simona Stratulat Ltd | Wholesale & retail | 2024 |
| Simple Services BPO Ltd | Administrative & support | 2026 |
| Simply Bespoke by Fran Limited | Hospitality | 2023 |