| DNR Property Ltd | Construction | 2018 |
| DO Property Investments LLP | | 2025 |
| DOA Spice and Foods Limited | Hospitality | 2023 |
| Doctors Pharmacy Limited | Administrative & support | 2010 |
| Dolce Vita MCR Limited | Hospitality | 2024 |
| Dolphin Swim Group Ltd | Education | 2018 |
| Dominant Jeans Ltd | Extraterritorial | 2021 |
| Domivka Shine Limited | Administrative & support | 2025 |
| Donec Woods Limited | Professional & scientific | 2019 |
| Donmez Handyman&Interior Decoration Ltd | Construction | 2021 |
| Dons Developments Ltd | Construction | 2025 |
| Dookeh Trade Limited | Wholesale & retail | 2023 |
| Doorcall Limited | Manufacturing | 2008 |
| Dopharma Ltd | Wholesale & retail | 2022 |
| DOS Hermanos Tapas Ltd | Hospitality | 2024 |
| Dots Frocks Limited | Wholesale & retail | 2025 |
| Doubleclick Traders Ltd | Wholesale & retail | 2025 |
| Dovehouse Residents Management Limited | Households | 1997 |
| DOW Chemical Company Limited | Manufacturing | 1954 |
| DOW Chemical Services UK Limited | Administrative & support | 2010 |
| DOW Services Trustees UK Limited | Professional & scientific | 2010 |
| DPM Garden Services Limited | Administrative & support | 2020 |
| DPS Windows Limited | Construction | 2010 |
| DR Aesthetic Cheadle Ltd | Health & social care | 2024 |
| DR Drippp Limited | Health & social care | 2024 |
| DR Gaitis Aesthetics Limited | Health & social care | 2015 |
| DR Hardman Holdings Limited | Education | 2023 |
| DR TIM Pearce Ltd | Health & social care | 2016 |
| Dr.Ismail Engineering Services Limited | Professional & scientific | 2026 |
| Dr.Sofya Locum Services Ltd | Health & social care | 2012 |
| Draw Architecture Ltd. | Real estate | 2014 |
| Drawing Board Solutions Limited | Information & communication | 2005 |
| Dream Move Relocation Ltd | Real estate | 2013 |
| Dreambytes Computers Limited | Other services | 2015 |
| Dreamstay Properties Ltd | Real estate | 2019 |
| Dress ME by Shaz PVT Ltd | Wholesale & retail | 2022 |
| Drinkseals Limited | Wholesale & retail | 2022 |
| Driscoll Brothers Group Limited | Professional & scientific | 1991 |
| Driscoll Brothers Holdings Limited | Financial services | 2020 |
| Driscoll Brothers Properties Limited | Real estate | 2020 |
| Driscoll Properties Limited | Real estate | 2021 |
| Drive Further Limited | Professional & scientific | 2012 |
| DRP Hospitality Limited | Hospitality | 2023 |
| DS Pharmaceuticals Limited | Wholesale & retail | 2024 |
| DS2 Group Ltd | Wholesale & retail | 2025 |
| DSB Floor Services Ltd | Construction | 2025 |
| DSG Roofing & Building Ltd | Construction | 2021 |
| DT SIX Ltd | Professional & scientific | 2024 |
| DTA Digital Consultancy Ltd | Information & communication | 2024 |
| DTC Interpreting Ltd | Professional & scientific | 2023 |
| DTL (Delaney Transport & Logistics) Ltd | Transport & logistics | 2025 |
| DTL Heavy Equipment Ltd | Manufacturing | 2026 |
| Dualdrive Limited | Administrative & support | 2018 |
| Duldul Ltd | Wholesale & retail | 2020 |
| DUO Fabrics Ltd | Wholesale & retail | 2019 |
| DVB Services (NW) Limited | Construction | 2009 |
| Dwellx Limited | Real estate | 2024 |
| Dwfco 9 Limited | Real estate | 2015 |
| Dynamic Analytical Limited | Professional & scientific | 2008 |
| Dynasty Chinese Takeaway (Cheadle Hulme) Ltd | Hospitality | 2023 |
| Dyslexia Assessments and Access Arrangements Ltd | Education | 2012 |
| E & SNH Holdings Limited | Administrative & support | 2017 |
| E Jude Ltd | Health & social care | 2011 |
| Eario Ltd | Professional & scientific | 2024 |
| Earn 2 Learn Limited | Education | 2023 |
| Earthas Consulting Ltd | Professional & scientific | 2023 |
| East Cheshire Decoration Limited | Construction | 2010 |
| East Enterprise Ltd | Real estate | 2024 |
| East Medical Ltd | Administrative & support | 2023 |
| Eastshore Pharm Ltd | Wholesale & retail | 2021 |
| Easyvan Plus Ltd | Transport & logistics | 2021 |
| EB Sales, Marketing and Book-Keeping Ltd | Wholesale & retail | 2020 |
| EBS Technologies Ltd | Wholesale & retail | 2020 |
| Eby's Properties Ltd | Real estate | 2026 |
| EC- Aspired Investing Ltd | Hospitality | 2024 |
| Ecern Limited | Wholesale & retail | 2024 |
| Eclectic Hair & Beauty Solutions Ltd | Other services | 2017 |
| Eco Chargepoints UK Limited | Construction | 2019 |
| Ecombase Ltd | Extraterritorial | 2023 |
| Ecombase Storage Ltd | Extraterritorial | 2021 |
| Economy Caravans Limited | Real estate | 1956 |
| Ecotrade Europe Ltd | Wholesale & retail | 2009 |
| ECS Consultants Limited | Professional & scientific | 2002 |
| ED Andrews Film Limited | Information & communication | 2017 |
| Eden Group Developments Ltd | Real estate | 2026 |
| Eden Park Chemical Consultancy Ltd | Professional & scientific | 2021 |
| Eden Park Medical Ltd | Health & social care | 2024 |
| Eden Point Developments Limited | Real estate | 2017 |
| Eden Rise Care Ltd | Health & social care | 2025 |
| Eden Sterling Ltd | Real estate | 2021 |
| Edmoti Ltd | Information & communication | 2026 |
| Educa Finance Limited | Financial services | 2022 |
| Educate Schools Ltd | Education | 2023 |
| Education Inventory Eams Ltd | Administrative & support | 2017 |
| Education Learning Trust | Education | 2014 |
| Educatius UK Limited | Education | 2013 |
| Edward Exley Limited | Manufacturing | 1948 |
| Edwardo's Catering Limited | Hospitality | 2019 |
| EEH Management Limited | Information & communication | 2016 |
| EEH Property Limited | Real estate | 2016 |