| Datern Limited | Information & communication | 2020 |
| Davenport Arms Ltd | Hospitality | 2023 |
| Davenport Flat Management Limited | Households | 1983 |
| David G Ross Limited | Wholesale & retail | 2004 |
| David Gallimore Limited | Information & communication | 2021 |
| David Hibbert Consultancy Services Limited | Professional & scientific | 2024 |
| David Madders Limited | Administrative & support | 2002 |
| Dawn Creative Limited | Information & communication | 2014 |
| Dawn Healthcare Ltd | Health & social care | 2019 |
| Daylesford Properties Limited | Real estate | 2000 |
| DC Auto Logistics Ltd | Transport & logistics | 2024 |
| DC Fitness Limited | Health & social care | 2013 |
| DC Gatley Limited | Hospitality | 2023 |
| DC Storage Ltd | Transport & logistics | 2024 |
| DCS Training,Development & Exercising Consultancy Limited | Professional & scientific | 2014 |
| DDG Group Limited | Extraterritorial | 2023 |
| Deal Lite Ltd | Information & communication | 2024 |
| Dealicious Mealz Limited | Wholesale & retail | 2012 |
| Deansgate Alexandra Drive Ltd | Real estate | 2021 |
| Deansgate Bath Road Ltd | Real estate | 2021 |
| Deansgate Group Ltd | Real estate | 2015 |
| Deansgate M15 Ltd | Real estate | 2024 |
| Deansgate M3 Limited | Real estate | 2008 |
| Deansgate M5 Limited | Real estate | 2009 |
| Deansgate SK8 Limited | Real estate | 2016 |
| Debarra Pharma Limited | Administrative & support | 2025 |
| Debt Scheme Direct Ltd | Financial services | 2012 |
| Deckchair Care Limited | Health & social care | 2017 |
| Declan Tarpey Building Envelope Consultant Ltd | Construction | 2018 |
| Deem Fmcg Sales Ltd | Wholesale & retail | 2026 |
| Deep Street Journeys Limited | Administrative & support | 2025 |
| Deepak Gupta Ltd | Health & social care | 2013 |
| Definition Limited | Administrative & support | 2004 |
| Deganwy Productions Limited | Arts & recreation | 2025 |
| Deignan Design Services Ltd. | Administrative & support | 2018 |
| Delamere Forest School Limited | Education | 2005 |
| Delanex Ltd | Information & communication | 2025 |
| Delaney-Turner Holdings Ltd | Financial services | 2025 |
| Delicate Life Limited | Wholesale & retail | 2023 |
| Deluxe Developments (UK) Limited | Construction | 2014 |
| Deluxe Repro Limited | Administrative & support | 2016 |
| Dementia Care Solutions Ltd | Health & social care | 2023 |
| Demix Global Limited | Information & communication | 2025 |
| Dentak Care and Services Limited | Health & social care | 2013 |
| Denton Orthodontic Centre Limited | Health & social care | 2009 |
| Depleach Clothing Limited | Wholesale & retail | 2021 |
| Derry Family Investments Limited | Financial services | 2022 |
| DES Eyes Ltd | Health & social care | 2018 |
| Desi Swaad Limited | Hospitality | 2024 |
| Desna Properties Ltd | Real estate | 2025 |
| Deva Hair Academy Limited | Wholesale & retail | 2024 |
| Devops Talent Limited | Administrative & support | 2020 |
| Devsoft Information Technologies Ltd | Information & communication | 2021 |
| Dewelop Ltd | Construction | 2021 |
| Dewty Beauty Limited | Wholesale & retail | 2019 |
| DG 360 Properties Limited | Real estate | 2022 |
| DH Bespoke Gates Limited | Manufacturing | 2017 |
| Dharmasena & Daughters Ltd | Health & social care | 2022 |
| Dharmasena Medical Consultations Ltd | Health & social care | 2024 |
| DHT Media Ltd | Information & communication | 2022 |
| DI Charms Ltd | Manufacturing | 2024 |
| Diamond Executive Transfers Ltd | Transport & logistics | 2026 |
| Diamond Point Global Group Ltd | Wholesale & retail | 2022 |
| Didsbury Clubhouse Limited | Hospitality | 2021 |
| Didsbury F.C. Limited | Arts & recreation | 2003 |
| Didsbury Playing Fields Association | Arts & recreation | 2011 |
| Didsbury Road Holdings Limited | Real estate | 2024 |
| Didsbury Road Limited | Real estate | 2024 |
| Didsbury Sports Ground Limited | Arts & recreation | 1981 |
| Digi Accounting Ltd | Professional & scientific | 2017 |
| Digi Mark Experts Ltd | Information & communication | 2024 |
| Digi PM Limited | Professional & scientific | 2023 |
| Digi-Api Solutions Ltd | Information & communication | 2019 |
| Digital Demystified Limited | Information & communication | 2021 |
| Dilbersb Limited | Professional & scientific | 2025 |
| Dimaq Consultancy Ltd | Information & communication | 2021 |
| Dimaq Properties Ltd | Real estate | 2022 |
| Dimmick Property Investments Ltd | Real estate | 2025 |
| Dingle Lettings Ltd | Real estate | 2013 |
| Direct Roofing (North West) Ltd | Construction | 2013 |
| Discount Leather Mart Limited | Wholesale & retail | 2014 |
| Disos Limited | Wholesale & retail | 1986 |
| Disstech Solutions Limited | Construction | 2000 |
| DIT Homes Limited | Real estate | 2026 |
| Divine Consultant FZ Ltd | Professional & scientific | 2010 |
| Division 1 Deluxe Ltd | Real estate | 2023 |
| DJT Finance Solutions Limited | Information & communication | 2020 |
| DK Investing Consultancy Ltd | Professional & scientific | 2021 |
| DKG Construction & Design Limited | Construction | 2019 |
| Dkstoresuk Ltd | Wholesale & retail | 2026 |
| DL Joinery & Building Services Limited | Construction | 2026 |
| DLG Financial Services Ltd | Administrative & support | 2026 |
| DLM Lead Services Ltd | Financial services | 2019 |
| DLS Commercial Developments Limited | Construction | 2021 |
| DM Holdings & Investments Ltd | Real estate | 2019 |
| DM Senior Care Limited | Health & social care | 2017 |
| DMA Consulting Ltd | Professional & scientific | 2024 |
| DMD Consultancy Limited | Health & social care | 2022 |
| DMM Hosting Limited | Information & communication | 2012 |
| DNL Distributions FBA Ltd | Wholesale & retail | 2025 |