| Eeiwa Limited | Health & social care | 2022 |
| EEK Commerce Ltd | Extraterritorial | 2024 |
| Eiger Composite Doors Ltd | Construction | 2004 |
| Eiger Doors & Windows Ltd | Construction | 2026 |
| Eign Holdings Limited | Financial services | 2024 |
| Eisa Bakery Ltd | Manufacturing | 2024 |
| Eisen Holdings Ltd | Real estate | 2023 |
| EJH Accounting (Cheshire) Limited | Professional & scientific | 2013 |
| EK4 Property Ltd | Real estate | 2025 |
| EKE Ltd | Professional & scientific | 2017 |
| Elaminlondon Ltd | Other services | 2025 |
| Elco Laser Engraving Limited | Professional & scientific | 2021 |
| Electric Head Software Limited | Information & communication | 2009 |
| Electro Adda UK Ltd | Wholesale & retail | 2014 |
| Elegant IP Limited | Administrative & support | 2026 |
| Elemar Cafe Ltd | Hospitality | 2023 |
| Elementar UK Limited | Manufacturing | 2007 |
| Elendel Limited | Wholesale & retail | 2025 |
| Elevate Assessments Limited | Information & communication | 2022 |
| Elevate Education Hub Limited | Education | 2025 |
| Elevate Group Ltd | Financial services | 2026 |
| Elevate II Limited | Professional & scientific | 2015 |
| Elevate III Limited | Health & social care | 2022 |
| Elevate Propco Limited | Real estate | 2015 |
| Elevate Virtual Assistant Ltd | Administrative & support | 2022 |
| Eleven Seven Group Limited | Professional & scientific | 2025 |
| Elevenfour Investments Limited | Financial services | 2025 |
| Elhoc Ltd | Professional & scientific | 2016 |
| Elicit Clothing Ltd | Extraterritorial | 2021 |
| Elit Clinic Ltd | Health & social care | 2024 |
| Elite Courier Service Ltd | Transport & logistics | 2020 |
| Elite Electrical Works Limited | Construction | 2025 |
| Elite FC Football Club CIC | Arts & recreation | 2026 |
| Elite K9 Academy Ltd | Information & communication | 2023 |
| Elite Sport Holdings Ltd | Arts & recreation | 2025 |
| Eliteform Limited | Education | 2002 |
| Ellabelle Investments Limited | Real estate | 2005 |
| Ellie Nails Ltd | Other services | 2025 |
| Elliott's Tree & Hedge Services Ltd | Agriculture & fishing | 2025 |
| Elmwood Mechanical & Electrical Services Limited | Construction | 2025 |
| Elnahasmed Limited | Health & social care | 2022 |
| Elopak UK Limited | Wholesale & retail | 1961 |
| Elpitha II Limited | Hospitality | 2018 |
| Elsa & Elvis | Financial services | 2017 |
| Elterwater Holdings Limited | Financial services | 2016 |
| Elterwater Investments Limited | Real estate | 1999 |
| Elum Ltd | Wholesale & retail | 2021 |
| Eluscidate Limited | Information & communication | 2020 |
| EM Skills Academy Ltd | Education | 2024 |
| Emaan EYE Health Ltd | Wholesale & retail | 2024 |
| Emaans Private Ltd | Other services | 2018 |
| Emarya Architecture Ltd | Construction | 2019 |
| Ember Lounge Limited | Hospitality | 2025 |
| Embroidery Matters Ltd | Wholesale & retail | 2025 |
| Emerald Path Ltd | Professional & scientific | 2012 |
| Emerge Coaching and Consulting International Ltd | Professional & scientific | 2022 |
| Emergency Metering Services Ltd | Construction | 2025 |
| Emergency Plumbers Manchester Limited | Construction | 2025 |
| Emily Maina Actuarial Consultant Ltd | Financial services | 2010 |
| Emily Victoria Candles Limited | Manufacturing | 2017 |
| Emiyus Ltd | Health & social care | 2020 |
| Emkaparts Limited | Administrative & support | 2023 |
| Emma Cartledge Marketing Limited | Professional & scientific | 2024 |
| Emma Gartside Ltd | Health & social care | 2022 |
| Emma Louise Consulting Ltd | Information & communication | 2013 |
| Empire Chauffeurs Limited | Transport & logistics | 2024 |
| Empowered Property Lifestyle Ltd | Education | 2023 |
| Empowher Online Coaching Ltd | Other services | 2023 |
| Emsd Ltd | Wholesale & retail | 2023 |
| Enabl Consulting Limited | Professional & scientific | 2020 |
| Enabl Courtyard Limited | Real estate | 2025 |
| Enableae Ltd | Information & communication | 2021 |
| Energy North West Ltd | Construction | 2016 |
| Enhance Clinical Aesthetics & Laser Ltd | Health & social care | 2025 |
| Enhance Clinical Aesthetics Ltd | Other services | 2018 |
| Enhance Clinical Training Ltd | Education | 2019 |
| Enhance Clinical Wholesale Ltd | Wholesale & retail | 2021 |
| Enhance Homes Ltd | Real estate | 2015 |
| Enigma Properties (U.K.) Limited | Information & communication | 1994 |
| Ennie Ltd | Wholesale & retail | 2023 |
| Enoch Catering Limited | Hospitality | 2023 |
| Entrus Limited | Manufacturing | 2011 |
| Enviroheat HET (UK) Limited | Manufacturing | 2015 |
| Enviroheat HET (France) Ltd | Extraterritorial | 2015 |
| Enviromose Limited | Extraterritorial | 2008 |
| Epco Energy Solutions Ltd | Construction | 2020 |
| Epco Properties Limited | Construction | 2023 |
| EPD Electrical Ltd | Construction | 2016 |
| Epic Developments (Northern) Limited | Real estate | 2013 |
| Eqes Ltd | Professional & scientific | 2000 |
| Equinox Eyecare Limited | Health & social care | 2025 |
| Equity Legal Services Limited | Professional & scientific | 2002 |
| Erbfmusic Limited | Arts & recreation | 2021 |
| Ernest J. George and Company Limited | Professional & scientific | 2002 |
| Erol Consultancy Ltd | Real estate | 2025 |
| Errington Consulting Limited | Professional & scientific | 2016 |
| ESA Risk Group Ltd | Administrative & support | 2011 |
| ESA Risk Ltd | Financial services | 2013 |
| Escala Capital Ltd | Professional & scientific | 2020 |
| ESG Janda Ltd | Wholesale & retail | 2020 |