| Serial 71 Limited | Arts & recreation | 2021 |
| Service Hydraulics Limited | Manufacturing | 2013 |
| Settle House Limited | Extraterritorial | 2005 |
| Settle House Property Ltd | Real estate | 2023 |
| Sevenless Therapeutics Limited | Professional & scientific | 2020 |
| Sextries Farm Management Company Limited | Households | 2002 |
| Sezcan Limited | Other services | 2020 |
| SG Store Limited | Wholesale & retail | 2015 |
| SGA Surveys Limited | Construction | 2015 |
| SH & K Ltd | Administrative & support | 2019 |
| Shadow Edge Limited | Wholesale & retail | 2025 |
| Shadowfall Services Limited | Professional & scientific | 2017 |
| Shaf Property Ltd | Real estate | 2026 |
| Shaffay Consulting Services Ltd | Professional & scientific | 2016 |
| Shah Rugs Limited | Wholesale & retail | 2025 |
| Shakara Logistics Limited | Transport & logistics | 2022 |
| Shake & Waffle Co Ltd | Hospitality | 2026 |
| Shalmsford Street Limited | Households | 2016 |
| Shapes Accounting Limited | Professional & scientific | 2015 |
| SHARE2SAIL Syndicate Two Limited | Arts & recreation | 2016 |
| Sharecentral Property Management Limited | Households | 1988 |
| Shared Direction Conveyancing Limited | Professional & scientific | 2022 |
| Sharif Billa Traders Limited | Wholesale & retail | 2025 |
| Sharks One Limited | Arts & recreation | 2016 |
| Sharpak Aylesham Limited | Manufacturing | 2010 |
| Shaun Tilley Consultancy Ltd | Real estate | 2022 |
| Shawarma Tantoura Ltd | Hospitality | 2026 |
| Shazlis Limited | Wholesale & retail | 2026 |
| SHE Properties Ltd | Construction | 2026 |
| Shed Ashford Kiosk Ltd | Hospitality | 2025 |
| Shed Folkestone Ltd | Hospitality | 2024 |
| Sheene Contract Solutions Limited | Construction | 2010 |
| Sheene Properties Limited | Administrative & support | 2013 |
| Sheerlink Limited | Professional & scientific | 1991 |
| Sheerness Recycling (Hythe) Limited | Water & waste | 2013 |
| Sheerness Recycling Limited | Water & waste | 2008 |
| Shelford MRF Limited | Water & waste | 2024 |
| Shelley Property Limited | Households | 2020 |
| Shellwood Blake Ltd | Administrative & support | 2010 |
| Shepherdswell Foot Health Limited | Health & social care | 2016 |
| Sherford Holdings Limited | Financial services | 2025 |
| Sherry Interiors Ltd | Wholesale & retail | 2023 |
| She’S a Bunny Boiler Productions Ltd | Professional & scientific | 2021 |
| Shiftly Ltd | Administrative & support | 2021 |
| Shiftxpress Ltd | Transport & logistics | 2024 |
| Shiloh Care Consultancy Ltd | Health & social care | 2017 |
| Shin GI TAI Martial Arts Academy LLP | | 2012 |
| Shin GI TAI Martial Arts UK LLP | | 2023 |
| Shiny Homes Cleaning Ltd | Administrative & support | 2026 |
| Shipping Cargo 2 Pakistan Ltd | Transport & logistics | 2025 |
| Shirtenvy.Com Ltd | Wholesale & retail | 2020 |
| Shiulie Limited | Hospitality | 1983 |
| Shiva TEC Ltd | Other services | 2023 |
| Shooting Technologies UK Limited | Wholesale & retail | 2025 |
| Shop-In-Pods Emporium Limited | Real estate | 2022 |
| Shopnovauk Ltd | Wholesale & retail | 2025 |
| Shoppable Ltd | Professional & scientific | 2017 |
| Shoppulse Ltd | Wholesale & retail | 2026 |
| Shopsyde Limited | Wholesale & retail | 2025 |
| Shortstay Collective Ltd | Real estate | 2024 |
| Shubunkin Limited | Construction | 2015 |
| Shumei Eiko Limited | Education | 1990 |
| Shumei Eiko Property Limited | Real estate | 1989 |
| SHY Punk Productions LLP | | 2019 |
| Sianora Pharm Ltd | Wholesale & retail | 2022 |
| Sibton Sporting Club Limited | Arts & recreation | 2022 |
| Sida Comms Ltd | Professional & scientific | 2023 |
| Sideralis Ltd | Professional & scientific | 2020 |
| Sidley Marion Limited | Administrative & support | 2015 |
| Siege Holdings Limited | Financial services | 2025 |
| Siege Scenics Limited | Wholesale & retail | 2023 |
| Siege Studios Limited | Arts & recreation | 2014 |
| Siel 2022 Ltd | Real estate | 2023 |
| Sigma Creative Support Limited | Health & social care | 2024 |
| SIGNATURE1UK Limited | Construction | 2015 |
| Signmark Ltd | Extraterritorial | 2022 |
| Siliver LIN Ltd | Wholesale & retail | 2025 |
| Silkbirds London Limited | Wholesale & retail | 2025 |
| Silkenshine Ltd | Wholesale & retail | 2024 |
| Silva Arboriculture Limited | Professional & scientific | 2017 |
| Silver Supermarket Ltd | Wholesale & retail | 2011 |
| Silverbacks Fitness Ltd | Arts & recreation | 2025 |
| Silverbacks MMA Ltd | Education | 2018 |
| Silverlake Press Ltd | Arts & recreation | 2015 |
| Silvernet Digital Limited | Information & communication | 2025 |
| Simara Developments Limited | Construction | 2017 |
| Simon Jordan Media Limited | Information & communication | 2017 |
| Simpatico.Agency Ltd | Professional & scientific | 2024 |
| Simpaul Designs Ltd | Wholesale & retail | 2018 |
| Simple Solutions Together Ltd | Administrative & support | 2021 |
| Simply Fruit Cakes Ltd | Manufacturing | 2009 |
| Simply Probate Limited | Public administration | 2024 |
| Simulation Motorsport Ltd | Wholesale & retail | 2024 |
| SIN SAR BA Ltd | Professional & scientific | 2025 |
| Sinclair Holdco Ltd | Financial services | 2023 |
| SIP Espresso Bar Ltd | Hospitality | 2024 |
| Sips N Giggles Ltd | Hospitality | 2026 |
| Sisanth Investments Ltd | Real estate | 2025 |
| Sittingbourne High Street Ltd | Construction | 2023 |
| Sittingbourne Property Ltd | Real estate | 2018 |