| Saint Antony's Retail Ltd | Wholesale & retail | 2022 |
| Saint Malo Limited | Construction | 2023 |
| Sales LAB London Ltd | Information & communication | 2024 |
| Salient Productions Limited | Information & communication | 2011 |
| Sallys Unisex Hairdressers Ltd | Other services | 2026 |
| Saloto Ltd. | Wholesale & retail | 2014 |
| Salt Canterbury Ltd | Hospitality | 2024 |
| Salvatori Food Service Ltd | Wholesale & retail | 2011 |
| Salvensis | Professional & scientific | 2012 |
| Salvilla-Punzalan Limited | Health & social care | 2013 |
| Salvo Futureuse Ltd | Other services | 2025 |
| Salvo Ltd | Construction | 1998 |
| SAM Andrew Ltd | Other services | 2017 |
| SAM HCW Ltd | Wholesale & retail | 2019 |
| SAM Mckee Limited | Administrative & support | 1997 |
| Samford Properties Limited | Real estate | 2012 |
| Samtelg Ltd | Health & social care | 2023 |
| Samurai Group Ltd | Wholesale & retail | 2015 |
| Sana Vita Limited | Health & social care | 2023 |
| Sandra Berk & Alex Dietze Limited | Professional & scientific | 2019 |
| Sandwich Management Company Limited | Real estate | 1989 |
| Sandwich Town Football Club Limited | Arts & recreation | 2023 |
| Santander Salt Limited | Administrative & support | 2010 |
| Santos Land Investments Limited | Real estate | 2022 |
| Sapphire Health Limited | Administrative & support | 2025 |
| Sarah Dare Therapies Ltd | Health & social care | 2025 |
| Sarah Westwell Oncology Care Ltd | Health & social care | 2025 |
| Saras Capital Co-Invest I LLP | | 2021 |
| Saras Capital Founder Limited | Extraterritorial | 2020 |
| Saras Capital II GP Limited | Financial services | 2023 |
| Saras Capital II LP | | 2024 |
| Saras Capital LLP | | 2020 |
| Saras Capital Second GP LLP | | 2020 |
| Sard JV Ltd. | Information & communication | 2012 |
| Sarre Court (Freehold) Limited | Households | 2015 |
| Sarre Penn Holdings Ltd | Construction | 2025 |
| SAS Investments Kent Ltd | Real estate | 2022 |
| Sash Catering Limited | Hospitality | 1993 |
| Sattyampihu Ltd | Health & social care | 2024 |
| Savanna Living Limited | Health & social care | 2021 |
| Savanna Professional Servces Limited | Professional & scientific | 2022 |
| Savanna Real Estate Limited | Real estate | 2021 |
| Savin Construction Consultants Limited | Professional & scientific | 2018 |
| Savvi Wear Ltd | Wholesale & retail | 2022 |
| Saward & Son's Ltd | Construction | 2026 |
| Saxon Fisheries (UK) Limited | Agriculture & fishing | 2003 |
| Saxon Place (Harrietsham) Resident Management Company Limited | Households | 2016 |
| Saxon Power Limited | Other services | 2004 |
| Sayers Electrical Services Ltd | Construction | 2025 |
| Sazant Coaching and Consulting Ltd | Professional & scientific | 2025 |
| SB Holdings Kent Ltd | Real estate | 2026 |
| SB Properties South East Limited | Real estate | 2024 |
| SBB Scaffolding Services Ltd | Construction | 2021 |
| Sbbq Restaurant Ltd | Hospitality | 2025 |
| SBT Ventures Limited | Financial services | 2025 |
| SBY Electrical Contracting Limited | Construction | 2023 |
| SC Starlight Ltd | Administrative & support | 2022 |
| Scalubs Properties Limited | Construction | 2016 |
| Scary Rides Limited | Information & communication | 2004 |
| Scfox Consultancy Limited | Professional & scientific | 2017 |
| Schaumburg Construction Ltd | Construction | 2014 |
| Scootfix Garage Limited | Wholesale & retail | 2025 |
| Scotland & Bates Ltd | Transport & logistics | 2018 |
| Scotsbridge Healthcare Limited | Health & social care | 2022 |
| Scott Wittman Design Limited | Professional & scientific | 2025 |
| Screenloop Ltd | Information & communication | 2021 |
| Screenx Ltd | Extraterritorial | 2021 |
| Sculfor House Management Services Limited | Households | 1990 |
| SDP Plumbing and Heating Limited | Construction | 2013 |
| Sdvault Limited | Professional & scientific | 2014 |
| SE1 Media Limited | Professional & scientific | 2006 |
| Seabrook Heights Apartments Ltd | Households | 2025 |
| Seafarer (Canterbury) Limited | Hospitality | 2022 |
| SEAG8 Limited | Transport & logistics | 2011 |
| Seasalter Trading Ltd | Wholesale & retail | 2021 |
| Seasonal Bliss CC Ltd | Construction | 2025 |
| Seathwaite Boarding Cattery Limited | Administrative & support | 1997 |
| Seaviolet Ltd | Real estate | 2024 |
| SEC Works Group Centre of Excellence CIC | Professional & scientific | 2023 |
| Second Harvest Limited | Agriculture & fishing | 2024 |
| Second Law Theatre Company Ltd | Arts & recreation | 2025 |
| Secure Construction Group Limited | Construction | 2017 |
| SEE IT Happen LLP | | 2021 |
| SEE IT Happen Member Limited | Professional & scientific | 2021 |
| Seed the Village CIC | Education | 2026 |
| Seerah Limited | Hospitality | 2022 |
| Selectika Limited | Information & communication | 2023 |
| Selsted Farm Developments Limited | Construction | 2007 |
| Seluto Limited | Other services | 2022 |
| Selwood PM Ltd | Professional & scientific | 2018 |
| SEN Beverage Services Limited | Administrative & support | 2024 |
| SEN Professionals Limited | Education | 2019 |
| Senacre Cycles Limited | Wholesale & retail | 2004 |
| Sensible Carpentry Solutions Limited | Construction | 2014 |
| Sentinel Consultants (UK) Limited | Professional & scientific | 2006 |
| Sentinel Consultants (UK) LLP | | 2010 |
| Sequence HQ Ltd | Information & communication | 2021 |
| Seraphic Homes Limited | Construction | 2020 |
| Serene Wellbeing Ltd | Health & social care | 2022 |
| Sergiho Uniform Ltd | Manufacturing | 2019 |