| Smart Alarms Systems Ltd | Administrative & support | 2025 |
| Smart Homes (Cannock) Limited | Construction | 2004 |
| Smart Industrial Properties Limited | Real estate | 2019 |
| Smart Space Stair Storage Ltd | Construction | 2023 |
| Smartagency.Direct Ltd | Administrative & support | 2015 |
| Smartemis Limited | Education | 2022 |
| Smarts Holdings Limited | Financial services | 2018 |
| Smerea Transport Ltd. | Transport & logistics | 2014 |
| Smith & Knight Electrical Limited | Construction | 2026 |
| Smith Ginger Limited | Information & communication | 2009 |
| Smithfix Ltd | Construction | 2021 |
| Smlv 03 Holdings Limited | Professional & scientific | 2026 |
| Smlv 03 Investments Limited | Professional & scientific | 2026 |
| Smokey Joez Ltd | Wholesale & retail | 2016 |
| Smoothmove Properties Limited | Real estate | 2023 |
| SN Roofing Services Ltd | Construction | 2024 |
| Snack Hub Staffordshire Ltd | Hospitality | 2020 |
| Snag Force Ltd | Construction | 2022 |
| Snookes Family Limited | Hospitality | 2022 |
| Snosnuff Ltd | Manufacturing | 2025 |
| Sofa Gallery Holdings Limited | Financial services | 2022 |
| Sofa Gallery Limited | Manufacturing | 1994 |
| Sojo & Co Cuts Limited | Other services | 2022 |
| Sojo & Co Hair Limited | Other services | 2022 |
| Sojo & Co Weddings Limited | Other services | 2022 |
| Solar Panel Pro Ltd | Construction | 2026 |
| Sole Property & Construction LLP | | 2018 |
| Sole Property Ltd | Real estate | 2018 |
| Solihullpiano Limited | Information & communication | 2007 |
| Soljet Construction Limited | Construction | 2015 |
| Solo Signs UK Limited | Manufacturing | 2011 |
| Somerville Investments Limited | Financial services | 2023 |
| Sonic Care Ltd | Health & social care | 2017 |
| Sophie Warnock Limited | Information & communication | 2021 |
| Sophisticated Beauty Limited | Other services | 2010 |
| SOR Energy Ltd | Construction | 2024 |
| SOS Property Solutions Limited | Administrative & support | 2020 |
| Soul Care Aesthetics Ltd | Wholesale & retail | 2014 |
| Soul Care Holdings Ltd | Real estate | 2022 |
| Source Solution Limited | Real estate | 2022 |
| South Cliff Roker Management Limited | Households | 2025 |
| South Stafford UK Consultancy Services Limited | Real estate | 2000 |
| South Staffs Acrobatics Limited | Arts & recreation | 2007 |
| South Staffs Air Conditioning Ltd | Energy | 2019 |
| South Staffs Air-Conditioning Services Ltd | Energy | 2025 |
| South Staffs Airbnb Management Ltd | Real estate | 2026 |
| South Staffs Cleaning Specialists Ltd | Administrative & support | 2025 |
| South Staffs Couriers Limited | Transport & logistics | 2013 |
| Sovereign Service Group Ltd | Construction | 2024 |
| SP & TP Services Ltd | Professional & scientific | 2017 |
| SP Cannock Limited | Hospitality | 2025 |
| SP Financial Ltd | Information & communication | 2024 |
| Sparklier Limited | Wholesale & retail | 2024 |
| Spartan Trading Limited | Wholesale & retail | 2013 |
| Specialist Medical and Resuscitation Training Ltd. | Education | 2018 |
| Specialist Physiological Services Limited | Health & social care | 2024 |
| Spedder Consulting Services Limited | Extraterritorial | 2008 |
| Speedway Motorcycles Limited | Wholesale & retail | 2016 |
| Speedwell 6300 (Birmingham) Ltd | Real estate | 2019 |
| Speedwell 6300 Ltd | Information & communication | 2012 |
| Speedwell 6300 Property Services Ltd | Real estate | 2015 |
| Speedy Enterprise Ltd | Wholesale & retail | 2024 |
| Spencer Moore Building and Maintenance Limited | Construction | 2011 |
| Spheracon Limited | Construction | 2022 |
| Spiral Cellars Limited | Construction | 2004 |
| Spiral Wine Cellars Limited | Extraterritorial | 2008 |
| Spittal Rise Limited | Households | 2023 |
| Sportz Connexions Limited | Arts & recreation | 2017 |
| Spotless Auto Valet Services Ltd | Wholesale & retail | 2020 |
| Spotlight Academy Dapa LLP | | 2026 |
| Spotlight Academy Limited | Arts & recreation | 2009 |
| SPR Business Ltd | Hospitality | 2025 |
| Spraybooths Direct Ltd | Manufacturing | 2020 |
| Springfield Heating & Mechanical Services Limited | Construction | 1998 |
| Springslade Lodge Ltd | Hospitality | 2015 |
| Springvalelettings Ltd | Real estate | 2026 |
| SPS Commercial Limited | Construction | 2017 |
| Spyglass Consulting Limited | Administrative & support | 2013 |
| SRA Cost Consultants Limited | Professional & scientific | 2014 |
| SRB Partners Ltd | Professional & scientific | 2025 |
| SRB Plant Limited | Manufacturing | 2002 |
| SRS Electrical Limited | Construction | 2006 |
| SRS Housing Limited | Real estate | 2026 |
| SRW Electrical Solutions Ltd | Construction | 2025 |
| SS Accountancy Services Midlands Limited | Professional & scientific | 2018 |
| SSB Medical Ltd | Health & social care | 2019 |
| SSD Medics Limited | Health & social care | 2025 |
| SSL Pinnacle Projects Ltd | Real estate | 2025 |
| SSR Investments (UK) Ltd | Real estate | 2023 |
| ST Thomas CH Ltd | Health & social care | 2024 |
| Stadium Garage (Cannock) Limited | Wholesale & retail | 2024 |
| Stafford and Rural Travel Ltd | Transport & logistics | 2025 |
| Stafford Invest Ltd | Health & social care | 2023 |
| Stafford Park 15 Management Company Ltd | Real estate | 2017 |
| Stafford Properties Limited | Real estate | 2020 |
| Staffordshire Consultancy Limited | Professional & scientific | 2002 |
| Staffordshire Crane Hire Ltd | Administrative & support | 2014 |
| Staffordshire Flooring Ltd | Construction | 2023 |
| Staffordshire Home Improvements Limited | Wholesale & retail | 2021 |
| Staffordshire Leisure Leagues Limited | Arts & recreation | 2021 |