| Staffordshire Property Investment Fund Limited | Financial services | 2000 |
| Staffordshire Roofing Supplies Limited | Construction | 2024 |
| Staffordshire Sheds Ltd | Manufacturing | 2010 |
| Staffordshire Wildlife Hides Limited | Arts & recreation | 2024 |
| Staffs Roofing & Consultancy Services Ltd | Professional & scientific | 2024 |
| Staffs. Comms. Limited | Information & communication | 2003 |
| Stag Carpentry & Joinery Ltd | Manufacturing | 2021 |
| Stag Heating Solutions Ltd | Construction | 2026 |
| Stag Property & Holdings Limited | Financial services | 2021 |
| Stag Property Services Ltd | Real estate | 2023 |
| Stag Safety and System Scaffold Ltd | Construction | 2018 |
| Stag Services and Facilities Limited | Construction | 2022 |
| Staggtek Services Ltd | Manufacturing | 2024 |
| Stainless Kitchen Solutions Limited | Manufacturing | 1961 |
| Stairlifts Midlands Installations Ltd | Construction | 2020 |
| Stairlifts Midlands Limited | Manufacturing | 2015 |
| Stakapal Limited | Manufacturing | 1967 |
| Staknstore Limited | Manufacturing | 2012 |
| Staley Consultancy Limited | Professional & scientific | 2014 |
| Stalworth Wealth Ltd | Financial services | 2020 |
| Stanaway Group Ltd | Professional & scientific | 2025 |
| Standard Sporting Guns Limited | Extraterritorial | 1927 |
| Standby Holding UK Ltd | Professional & scientific | 2003 |
| Standby RSG UK Limited | Manufacturing | 1985 |
| Standmode Ltd | Professional & scientific | 2004 |
| Stanley.S Transport Ltd | Transport & logistics | 2025 |
| Star Installation (Contractors) Limited | Construction | 1986 |
| Station Accountants Limited | Professional & scientific | 2019 |
| Station Cafe (Cannock) Limited | Hospitality | 2016 |
| STB Industrial Services Limited | Construction | 2015 |
| STC Cornwall Limited | Energy | 2004 |
| STC Packers Ltd. | Agriculture & fishing | 2003 |
| STC Property Limited | Real estate | 2014 |
| Stealth Insulations Limited | Construction | 2008 |
| Steel & Cladding Limited | Construction | 2009 |
| STEEL4 Limited | Information & communication | 2000 |
| Steers Plastering Contractors Limited | Construction | 2016 |
| Steers Properties Limited | Households | 2025 |
| Sterling Separation Limited | Wholesale & retail | 2006 |
| Steve Bull Enterprises Limited | Administrative & support | 2003 |
| Steve Grainger Engineering Limited | Professional & scientific | 2016 |
| Steve's Fish Bar Measham Ltd | Hospitality | 2021 |
| Steven a Goodyear Limited | Information & communication | 2017 |
| Steven Pagett Ecological Services Ltd | Professional & scientific | 2024 |
| Stevenson Training & Consultancy Limited | Professional & scientific | 2012 |
| Steventon Assessments Limited | Health & social care | 2021 |
| Stickershack Ltd | Wholesale & retail | 2024 |
| Stikit Label Company Limited | Manufacturing | 1996 |
| Stique Limited | Manufacturing | 2014 |
| Stirling Educational Advisory Services Limited | Education | 2024 |
| Stober Drives Limited | Manufacturing | 2000 |
| Stock Must Go Limited | Extraterritorial | 2021 |
| Stockdown Holdings Ltd | Financial services | 2026 |
| Stonebeech Court Management Company Limited | Real estate | 2020 |
| Stoneycroft Gardens External Management Limited | Households | 1989 |
| Stoneycroft Gardens Internal Management Limited | Households | 1989 |
| Storage Equipment Manufacturing Company Limited | Manufacturing | 1998 |
| Storm Clinical Response Limited | Health & social care | 2026 |
| Storm Performance Centre Ltd | Arts & recreation | 2025 |
| Storytale Seekers Ltd | Health & social care | 2025 |
| Stove Flue Supplies Limited | Construction | 2016 |
| Streamline Fabrications Ltd | Manufacturing | 2025 |
| Strength Department Supplements Ltd | Wholesale & retail | 2025 |
| Strike Safe Limited | Other services | 2022 |
| Strokes Swimming Limited | Education | 2024 |
| Strokes Swimming School Limited | Education | 2024 |
| Strucsta Scope Limited | Professional & scientific | 2024 |
| Studio Kiki Ltd | Manufacturing | 2021 |
| Styled by Leah Ltd | Other services | 2022 |
| Styled by Limited | Other services | 2018 |
| Subscents Limited | Wholesale & retail | 2020 |
| Subscranners Ltd | Hospitality | 2025 |
| Subway Stores Plaza Limited | Hospitality | 2009 |
| Succeeding Ltd | Professional & scientific | 2022 |
| Suitescale Ltd | Information & communication | 2026 |
| Summer Vibe 365 Ltd | Wholesale & retail | 2025 |
| Summit Marketing Global Ltd | Professional & scientific | 2023 |
| Summit North West Limited | Professional & scientific | 2021 |
| Summit Scanner Ltd | Information & communication | 2026 |
| Sunbed Studio & Wellness Ltd | Other services | 2021 |
| Sunday Hair Co. Ltd | Wholesale & retail | 2026 |
| Sunfield Build Ltd | Construction | 2017 |
| Supaprint (Cannock) Limited | Manufacturing | 2006 |
| Super Sharky's Swim School Limited | Arts & recreation | 2006 |
| Super Smart Service Ltd | Transport & logistics | 2015 |
| Superior Finish Decorating Services Ltd | Construction | 2010 |
| Supersxcgemabackup Ltd | Wholesale & retail | 2025 |
| Supreme Car Detailing - Birmingham Ltd | Wholesale & retail | 2024 |
| Supreme Car Detailing - Stafford Ltd | Wholesale & retail | 2025 |
| Supreme Car Detailing - Walsall Ltd | Wholesale & retail | 2025 |
| Supreme Car Detailing - Wolverhampton Ltd | Other services | 2024 |
| Supreme Car Detailing Coventry Limited | Wholesale & retail | 2026 |
| Supreme Car Detailing Derby Limited | Wholesale & retail | 2026 |
| Supreme Car Detailing Ltd | Wholesale & retail | 2022 |
| Supreme Car Detailing Stoke Limited | Wholesale & retail | 2026 |
| Supreme Car Detailing Telford Limited | Wholesale & retail | 2026 |
| Supreme Interior Solutions Ltd | Construction | 2018 |
| Supreme Investments (Midlands) Ltd | Real estate | 2026 |
| Supreme Partner Programme Limited | Financial services | 2026 |
| Sure Chemicals Limited | Manufacturing | 1988 |