| Seven Cleaning &Co Limited | Administrative & support | 2026 |
| Seven Property Staffs Ltd | Households | 2018 |
| Seymour Displays Limited | Wholesale & retail | 2009 |
| Seymour's Spraying Training & Development Ltd | Education | 2023 |
| SF Bookkeeping Limited | Professional & scientific | 2025 |
| Sgcatering Group Ltd | Administrative & support | 2019 |
| SGF Commercials Ltd | Wholesale & retail | 2025 |
| SH (2024) Limited | Professional & scientific | 2024 |
| SH Consultancy International Ltd | Professional & scientific | 2024 |
| Shadow Insurance Services Limited | Financial services | 2013 |
| Shady Bakes Ltd | Hospitality | 2025 |
| Shake That Patty Ltd | Hospitality | 2025 |
| Shalloe Cooper Estates Ltd | Real estate | 2015 |
| Shardlow Digital Ltd | Professional & scientific | 2023 |
| Shareflow Management Limited | Households | 2026 |
| Shareshill Motor Company Limited | Wholesale & retail | 2002 |
| Sharrard Ltd | Wholesale & retail | 2010 |
| Shaw Bishop Holdings Ltd | Financial services | 2016 |
| Shaw Lettings Ltd | Real estate | 2016 |
| Shaw Property Management Services Ltd | Households | 2021 |
| Sheep Fair Management Ltd | Households | 2021 |
| Sheldon Buchanan Ltd | Manufacturing | 2020 |
| Shelvoke, Pickering, Janney LLP | | 2013 |
| Shillco Investments Ltd | Professional & scientific | 2024 |
| Shilling Group Limited | Professional & scientific | 2022 |
| Shilling Mergers Limited | Other services | 2009 |
| Shilling Property Limited | Real estate | 2020 |
| Shilling Trading Limited | Professional & scientific | 2014 |
| Shilling Trustee Holdings Limited | Professional & scientific | 2019 |
| Shirewood Holdings Limited | Real estate | 2020 |
| Shirley Transport Solutions Limited | Transport & logistics | 2019 |
| Shoal 57 Limited | Construction | 2024 |
| Shop 4 U Limited | Wholesale & retail | 2008 |
| Shorade Accident Repair Centre Limited | Wholesale & retail | 2003 |
| Shore and Country Ltd | Construction | 2023 |
| Shorecroft Stables Limited | Arts & recreation | 2025 |
| Showcase Crewing Services Limited | Information & communication | 2017 |
| Showker Holdings Limited | Financial services | 2018 |
| SID Lettings Limited | Households | 2021 |
| Side by Side Advocacy Ltd | Other services | 2026 |
| Signature Clinics Limited | Health & social care | 2021 |
| Signature Short Stays Limited | Households | 2026 |
| Signature Sofas Limited | Wholesale & retail | 2007 |
| Sikh AID Foundation Ltd | Health & social care | 2017 |
| Silvaflame-Cleervue Co. Ltd | Administrative & support | 2007 |
| Silverbrick (Clayhanger) Ltd | Real estate | 2020 |
| Silverbrick Holdings Limited | Professional & scientific | 2022 |
| Silverbrick Investments Ltd | Real estate | 2020 |
| Silverbrick Limited | Construction | 2013 |
| Silverline Accommodations Ltd | Real estate | 2026 |
| Silverline Home Improvements Ltd | Construction | 2022 |
| SIM Solutions (UK) Ltd | Manufacturing | 2009 |
| Simon John Crosby Limited | Construction | 2002 |
| Simon Quinton Limited | Other services | 2018 |
| Simone Joy Holdings Limited | Real estate | 2024 |
| Simple Subs Ltd | Hospitality | 2025 |
| Simpler Business Solutions Ltd | Professional & scientific | 2025 |
| Simply Storage-Dangerfield Co Ltd | Construction | 2017 |
| Simplycafe Limited | Hospitality | 2026 |
| Simplymind Meditation Ltd | Health & social care | 2019 |
| Simpson Khan Holdings Ltd | Financial services | 2021 |
| Simtrans Holdings Limited | Professional & scientific | 2023 |
| Simtrans Investments Limited | Professional & scientific | 2023 |
| Singh Captures Ltd | Information & communication | 2025 |
| Site Clear Solutions Ltd | Water & waste | 2007 |
| Sitech Technology Systems Limited | Wholesale & retail | 2013 |
| SJ Automotive Trading Limited | Wholesale & retail | 2025 |
| SJ Doors Ltd | Manufacturing | 2022 |
| SJA Precast Ltd | Construction | 2021 |
| SJA Training Services Ltd | Education | 2022 |
| SJB Golf Tuition Limited | Arts & recreation | 2010 |
| SJB Retail Ltd | Wholesale & retail | 2023 |
| SJC Pointing & Landscaping Ltd | Construction | 2024 |
| SJH Computing & Technical Services Limited | Information & communication | 2020 |
| SJP Heating Services Limited | Construction | 2019 |
| Sjssalessolutions (Midlands) Ltd | Professional & scientific | 2025 |
| SK Direct (UK) Limited | Wholesale & retail | 2005 |
| SK MAT Logistics Ltd | Transport & logistics | 2023 |
| SKG Electrical Limited | Construction | 2010 |
| Skinthetics by Sophie Limited | Other services | 2025 |
| SKP Carpentry Services Limited | Construction | 2017 |
| SKP Support Senses Ltd | Health & social care | 2025 |
| Skyline Timber Systems Ltd | Administrative & support | 2017 |
| SL PUB Co Ltd | Hospitality | 2018 |
| Slade Carpentry Limited | Construction | 2023 |
| Slade Signs Limited | Manufacturing | 2004 |
| Slann Developments Limited | Real estate | 2025 |
| Slarnt Capital Partners Limited | Financial services | 2016 |
| SLB Rigging Services Limited | Construction | 2014 |
| Sleep Assured Limited | Wholesale & retail | 2020 |
| Sleep Developments Properties Limited | Real estate | 2019 |
| Sleep Superstore Limited | Wholesale & retail | 2021 |
| Slice Culture Ltd | Hospitality | 2020 |
| SLJ Building Services Limited | Construction | 2023 |
| Sljpubs Ltd | Hospitality | 2026 |
| SLR Ceilings and Partitions Limited | Construction | 2019 |
| Slwacf Ltd | Health & social care | 2022 |
| Slyzviw Ltd | Health & social care | 2019 |
| SM Dental Care Limited | Health & social care | 2014 |
| SM Installations (West Midlands) Limited | Construction | 2021 |