| S W S Machining Limited | Manufacturing | 1999 |
| S&B Property Claims Ltd | Other services | 2025 |
| S. G. Construction (Midlands) Limited | Construction | 2010 |
| S.B.S. Business Systems Limited | Administrative & support | 1985 |
| S.J. Brookes & Associates Consulting Limited | Other services | 2013 |
| S.M.G. Trading Limited | Wholesale & retail | 1988 |
| S.N.A.P. (Special Needs Adventure Playground) Ltd | Other services | 1996 |
| S.O.R. Heating & Plumbing Ltd | Construction | 2012 |
| S.T. Electrical Project Services Ltd | Professional & scientific | 2019 |
| S.T.S. Garage & Industrial Doors Limited | Wholesale & retail | 2001 |
| S.W. Technology Limited | Information & communication | 2023 |
| S.Winfield Limited | Transport & logistics | 1971 |
| S7 Media Limited | Information & communication | 2008 |
| SA Costings Limited | Professional & scientific | 2019 |
| SA Mason Bricklaying Ltd | Construction | 2015 |
| SA Mchale Ltd | Administrative & support | 2024 |
| SA Property Innovations Ltd | Real estate | 2022 |
| Saaam Services Ltd | Real estate | 2017 |
| Sabre Protective Security Ltd | Administrative & support | 2015 |
| Saddlebrook Healthcare Services Ltd | Administrative & support | 2022 |
| Safe Consulting Limited | Professional & scientific | 2019 |
| Safe Driver UK Limited | Professional & scientific | 2012 |
| Safe Haven Training Limited | Education | 2018 |
| Safe-Tile UK Limited | Construction | 2026 |
| Safeguard Building Controls Limited | Construction | 2018 |
| Safelec Holdings Limited | Financial services | 2022 |
| Safelec Ltd | Water & waste | 2012 |
| SAH Surveying Ltd | Professional & scientific | 2023 |
| Salisbury Country Clothing Limited | Wholesale & retail | 2008 |
| Salmon & Associates (Cannock) Ltd | Real estate | 2015 |
| SAM Hart Coaching Limited | Health & social care | 2024 |
| Sams Potatoes Limited | Wholesale & retail | 2003 |
| Samuel & Co Associates Ltd | Real estate | 2012 |
| Samuel & Co Consultancy Limited | Professional & scientific | 2017 |
| Samuel & Co Estates Limited | Real estate | 2017 |
| Samuel & Co Holdings Limited | Real estate | 2017 |
| SAN Properties Limited | Real estate | 2025 |
| Sandford Dental Laboratory Ltd | Health & social care | 2024 |
| Sands Fish Limited | Wholesale & retail | 2016 |
| Sandy Lane Stables and Estates Ltd | Real estate | 2008 |
| Sanifix Service Limited | Wholesale & retail | 2011 |
| Sankey's Express Ltd | Wholesale & retail | 2025 |
| Santon Interiors Limited | Construction | 2025 |
| Sapphire Hair & Hair Extension Training Academy Limited | Other services | 2026 |
| Sarah Food Limited | Hospitality | 2023 |
| Sarah Rand Enterprises Limited | Health & social care | 2010 |
| Sarand Holdings Limited | Financial services | 2025 |
| Saras Catering Limited | Hospitality | 2018 |
| Sarson Properties Ltd | Extraterritorial | 2026 |
| SAS Building Limited | Construction | 2017 |
| Sasco Developments Limited | Administrative & support | 2008 |
| Sasco Investments Limited | Administrative & support | 2008 |
| Sassy Paws Limited | Wholesale & retail | 2025 |
| Savistute Holdings Limited | Administrative & support | 2026 |
| SAW Flooring Services Limited | Construction | 2018 |
| Saxon Gym Limited | Health & social care | 2023 |
| SB MAY Ltd | Real estate | 2021 |
| SB Utilities Ltd | Other services | 2024 |
| SB Vehicle Services Limited | Wholesale & retail | 2022 |
| SBS Insurance Services Limited | Information & communication | 2000 |
| Scholion Consulting Ltd | Professional & scientific | 2026 |
| Score (UK) Limited | Other services | 2012 |
| Scorpion Garage Services Limited | Transport & logistics | 2023 |
| Scott Franklin Associates Limited | Professional & scientific | 2017 |
| Scott Kelly Sealants Limited | Administrative & support | 2017 |
| Scouts View Management Company Limited | Real estate | 2022 |
| Screentechuk Limited | Manufacturing | 2016 |
| SCS WS11 Limited | Wholesale & retail | 2020 |
| SD & SON Utilities Ltd | Administrative & support | 2025 |
| SDB Transport Ltd | Transport & logistics | 2017 |
| SDC Property Services Limited | Construction | 2019 |
| SE Property Holdings Ltd | Financial services | 2023 |
| SE Property Portfolio Ltd | Real estate | 2023 |
| SE Property Renovations Ltd | Real estate | 2023 |
| Sea Raven Developments Ltd | Real estate | 2026 |
| Sea Raven Holdings Ltd | Financial services | 2026 |
| Sean Goodhead Tree Services Limited | Administrative & support | 2017 |
| Season Spice Ltd | Hospitality | 2024 |
| Seasons Direct Limited | Wholesale & retail | 2006 |
| Secure-Fix Installations Limited | Construction | 2010 |
| Securitec Systems Limited | Construction | 2005 |
| Seen on Screen Fitness & Events Limited | Arts & recreation | 2011 |
| Seera Associates Ltd | Administrative & support | 2023 |
| Seesurrun Holdings Limited | Professional & scientific | 2015 |
| Select & Save Express Limited | Other services | 2019 |
| Selene House of Beauty Ltd | Other services | 2024 |
| Sell 2 Recycle Ltd | Information & communication | 2023 |
| Semi-Sel Ltd | Financial services | 2024 |
| Senior Songs Limited | Information & communication | 2020 |
| Sennett Group Limited | Construction | 2023 |
| Senpora Ltd | Wholesale & retail | 2007 |
| Sepa Solutions Ltd | Manufacturing | 2023 |
| SEQUOIA9 Limited | Financial services | 2016 |
| Sercal NON Destructive Test Equipment Limited | Administrative & support | 1999 |
| Serenity 4 Women Ltd | Health & social care | 2024 |
| Serrulata Investments Limited | Financial services | 2024 |
| Serta Systems Ltd | Administrative & support | 2021 |
| Servevast Limited | Other services | 1993 |
| Servovy Limited | Transport & logistics | 2017 |
| SES Security Staff Limited | Administrative & support | 2022 |