| Engbear Ltd | Wholesale & retail | 2018 |
| Engineered Design Limited | Professional & scientific | 2013 |
| Engineered to Inspire Limited | Administrative & support | 2022 |
| Engineering Altfel Ltd | Manufacturing | 2025 |
| Engineering and Design Plastics Ltd | Manufacturing | 2002 |
| Engineering Hub Ltd | Professional & scientific | 2015 |
| Engineering Leaders Ltd | Professional & scientific | 2024 |
| Engineering Services JB Ltd | Manufacturing | 2014 |
| Engineering the Blue Limited | Professional & scientific | 2012 |
| Enginehead Ltd | Information & communication | 2003 |
| Engivent Ltd | Information & communication | 2024 |
| English Churchman Trust,Limited(The) | Other services | 1910 |
| Engxcel Ltd | Education | 2021 |
| Enhanced Genomics Limited | Professional & scientific | 2020 |
| Enhanced Speech Technology Ltd | Professional & scientific | 2013 |
| Enie Label Ltd | Manufacturing | 2019 |
| Enigmatic Properties Ltd | Real estate | 2025 |
| Enjoy Shine Trade Ltd | Wholesale & retail | 2024 |
| Enjyo Ltd | Information & communication | 2019 |
| Enku Enterprises Ltd | Real estate | 2025 |
| Enming Art Stone Co., Ltd. | Extraterritorial | 2012 |
| Enmson Electric Ltd | Extraterritorial | 2018 |
| Ennkaye Consulting Limited | Information & communication | 2021 |
| Ensocell Ltd | Professional & scientific | 2023 |
| Ensygnia IP Ltd | Information & communication | 2015 |
| Ensygnia Ltd | Information & communication | 2010 |
| Enterosorb Limited | Professional & scientific | 2024 |
| Enterprise Analytics Uk&I Ltd | Information & communication | 2022 |
| Enterprise Business Applications Limited | Information & communication | 2019 |
| Enterprise Consulting (UK) Ltd | Information & communication | 2002 |
| Enterprise Support Alliance Limited | Administrative & support | 2018 |
| Entertainment Technology Press Limited | Information & communication | 1999 |
| Entire Group Ltd | Construction | 2007 |
| Entomics Biosystems Limited | Agriculture & fishing | 2015 |
| Entrust Security UK Limited | Wholesale & retail | 2018 |
| Envea UK Ltd | Manufacturing | 1990 |
| Environ Systems Ltd | Manufacturing | 2014 |
| Environmental Material Management Ltd | Water & waste | 2019 |
| Environmental Research and Assessment (ERA) Limited | Professional & scientific | 1999 |
| Environmentally Friendly Cars Limited | Transport & logistics | 2023 |
| Envisia Learning Ltd. | Administrative & support | 2014 |
| Envision Greenwise Holdings (UK) Ltd. | Water & waste | 2025 |
| Envision Technical Solutions Ltd | Administrative & support | 2024 |
| Enway Education Ltd | Information & communication | 2024 |
| EOS Biotech Co., Ltd | Extraterritorial | 2011 |
| Eousun International Enterprises Limited | Wholesale & retail | 2011 |
| Epaika Limited | Information & communication | 2025 |
| Epay Trading Company Limited | Wholesale & retail | 2024 |
| EPE Leisure Limited | Arts & recreation | 2017 |
| EPG Development V LLP | | 2014 |
| Ephyra Limited | Professional & scientific | 2022 |
| Epic Garlic Ltd | Wholesale & retail | 2021 |
| Epic Medicine Limited | Information & communication | 2024 |
| Epic Services Limited | Administrative & support | 2023 |
| Epic Squib Limited | Financial services | 2020 |
| Epica Star World Limited | Wholesale & retail | 2025 |
| Epicam Limited | Manufacturing | 1999 |
| Epicharge Limited | Manufacturing | 2010 |
| Epicsa Limited | Hospitality | 2018 |
| Epilayers Limited | Professional & scientific | 2025 |
| Epiny Trade Ltd | Wholesale & retail | 2023 |
| Epiphany Theatre Ltd | Arts & recreation | 2024 |
| Epiqair Limited | Manufacturing | 2005 |
| Episys Limited | Information & communication | 1987 |
| Epitopea Limited | Professional & scientific | 2021 |
| Epmg Facilities Management Limited | Administrative & support | 2006 |
| Epmg Legal Limited | Extraterritorial | 2011 |
| Epmg Surveyors Limited | Extraterritorial | 2012 |
| Epmk Management Limited | Real estate | 1999 |
| Epoch Wires Limited | Manufacturing | 2013 |
| Epokay Ltd | Information & communication | 2021 |
| Epotechnologies Develop X Ltd | Real estate | 2021 |
| Epotechnologies Development Ltd | Real estate | 2019 |
| Epperstone Manor Freehold Limited | Households | 2020 |
| Epperstone Manor Management Company Limited | Households | 2008 |
| EPR Workflow Analysis Limited | Information & communication | 2022 |
| Epro Select Limited | Wholesale & retail | 2023 |
| EPS (Geomatics) Ltd | Professional & scientific | 2019 |
| EPS (Leeds) Ltd | Professional & scientific | 2019 |
| Epure Brand Ltd | Wholesale & retail | 2026 |
| EPV Investments Ltd | Real estate | 2016 |
| Eqsystems.Io Ltd | Professional & scientific | 2016 |
| EQU & Fair Ltd | Construction | 2025 |
| Equadata Ltd | Information & communication | 2023 |
| Equanimity International Ltd | Real estate | 2022 |
| Equatorial Grove Limited | Construction | 2025 |
| Equawake Ltd | Professional & scientific | 2026 |
| Equilibrium KIT Cars Ltd | Manufacturing | 2021 |
| Equilibrium Nutrition Ltd | Other services | 2022 |
| Equine Amigos U.K. Ltd | Agriculture & fishing | 2024 |
| Equine Respiratory Screening Ltd | Professional & scientific | 2013 |
| Equine Services Ltd | Other services | 2021 |
| Equinox Graphics Ltd | Information & communication | 2009 |
| Equisci Ltd | Manufacturing | 2025 |
| Equistock Ltd | Professional & scientific | 2002 |
| Equitas Estates Ltd | Administrative & support | 2012 |
| Equivital Holdings Limited | Financial services | 2014 |
| Equivital Limited | Manufacturing | 2007 |
| Er&Mg Holdings Ltd | Wholesale & retail | 2023 |
| ERA Films Limited | Information & communication | 2010 |