| Deeptech Labs Fund 1 LP | | 2021 |
| Deepti Healthcare Ltd | Health & social care | 2015 |
| Deepverse Ltd | Information & communication | 2020 |
| Deepvista Innovations Ltd | Information & communication | 2025 |
| Deepz Cleaning Ltd | Administrative & support | 2025 |
| Deevee Properties Ltd | Real estate | 2022 |
| Defence Shield Systems Limited | Public administration | 2025 |
| Define Creative Ltd | Professional & scientific | 2021 |
| Definia Tech Foundation | Information & communication | 2025 |
| Definitive Accounts Limited | Professional & scientific | 2005 |
| Defyent Studios Limited | Information & communication | 2020 |
| Dehler Group Co., Ltd | Transport & logistics | 2021 |
| Deian Healthcare Limited | Health & social care | 2017 |
| Deimantas Composites Limited | Manufacturing | 2022 |
| DEL Group Maintenance Limited | Construction | 2023 |
| Delbeck Accountancy Limited | Professional & scientific | 2005 |
| Delbeck Limited | Professional & scientific | 2003 |
| Deliciously Guilt Free Ltd | Hospitality | 2020 |
| Delik Ltd | Manufacturing | 2025 |
| Delizia Media Limited | Professional & scientific | 2021 |
| Della Kaur Limited | Wholesale & retail | 2013 |
| Delphinium FOX Ltd | Real estate | 2023 |
| Delta (Cambridge) Limited | Transport & logistics | 2014 |
| Delta and North Ltd | Wholesale & retail | 2023 |
| Delta Design and Engineering Limited | Manufacturing | 1991 |
| Delta M&E Ltd | Professional & scientific | 2024 |
| Delta Project Management Ltd. | Other services | 2011 |
| Delta-Fluidx Limited | Professional & scientific | 2025 |
| Deltasun Limited | | 1982 |
| Delves Construction Ltd | Construction | 2023 |
| Delwych Limited | Information & communication | 2010 |
| Demade Limited | Real estate | 2025 |
| Demand AI (UK) Ltd | Professional & scientific | 2024 |
| Demcko Limited | Information & communication | 2022 |
| Demeza Holdings Limited | Extraterritorial | 2019 |
| Demol Demol Services Limited | Health & social care | 2013 |
| Demont Properties Ltd | Real estate | 2021 |
| DEN of Antiquity International Limited | Wholesale & retail | 2003 |
| Den-San SRL Ltd | Manufacturing | 2025 |
| Denbigh House Residents Association (Norwich) Limited | Real estate | 1978 |
| Denchi EOT Limited | Extraterritorial | 2024 |
| Denchi Group Limited | Manufacturing | 2013 |
| Dencorn Ltd | Manufacturing | 2024 |
| Dendritx Ltd | Professional & scientific | 1997 |
| Denefield Gardens Management Company Limited | Households | 2004 |
| Dengrove Country Park Limited | Hospitality | 2018 |
| Denham Soho Ltd | Real estate | 2026 |
| Denham Vicarage Farm Limited | Agriculture & fishing | 2014 |
| Denis Air Ltd | Manufacturing | 2024 |
| Denis Paint Restoration Ltd | Wholesale & retail | 2026 |
| Denman & Partners LLP | | 2024 |
| Denmark House Wellness Centre Limited | Other services | 2025 |
| Denmatt Holdings Limited | Real estate | 2023 |
| Dennis FA Chemical Co., Ltd | Manufacturing | 2024 |
| Dennis Jinks Broadcast Engineering Limited | Professional & scientific | 2011 |
| Denniz Limited | Hospitality | 2016 |
| Densley Charles (Coachcraft) Ltd | Wholesale & retail | 2025 |
| Dentastique Limited | Extraterritorial | 2011 |
| Dentavet Equine Dentistry Ltd | Professional & scientific | 2020 |
| Dentium Medical Ltd | Health & social care | 2013 |
| Dentons Carpets Limited | Wholesale & retail | 2010 |
| Dents 2 Go Ltd | Manufacturing | 2023 |
| Denu Limited | Information & communication | 2009 |
| Depe International Ltd | Professional & scientific | 2018 |
| Dereasy Limited | Wholesale & retail | 2024 |
| Derek Bruce Limited | Professional & scientific | 2016 |
| Derisk Systems Ltd | Information & communication | 2025 |
| Derma SD Limited | Health & social care | 2025 |
| Dermazone Solutions Ltd | Other services | 2024 |
| Dermocore Ltd. | Wholesale & retail | 2012 |
| Dernford Farm Limited | Hospitality | 2025 |
| Dernford Investment Limited | Administrative & support | 2020 |
| Deronbrook Freehold Limited | Households | 2014 |
| Deronbrook Management Limited | Households | 1999 |
| Derringer Enterprises Limited | Extraterritorial | 2019 |
| Derui Home Industry Co., Ltd | Manufacturing | 2022 |
| Derwent House Holding Limited | Financial services | 2013 |
| Derwent Housing Management Company Limited | Households | 1982 |
| Derya Glass Design Ltd | Wholesale & retail | 2018 |
| DES Trade Ltd | Wholesale & retail | 2025 |
| DES3D Limited | Professional & scientific | 2026 |
| Deshmukh PVT Ltd | Health & social care | 2025 |
| Deshpande Limited | Health & social care | 2007 |
| Desi CAM Chaat Limited | Hospitality | 2025 |
| Design and Motion Ltd | Information & communication | 2025 |
| Design Care Professionals Ltd | Health & social care | 2025 |
| Design Edge Cambridge Limited | Professional & scientific | 1996 |
| Design for Life Properties Limited | Real estate | 2024 |
| Design IS Alive Limited | Information & communication | 2012 |
| Design Leaders Ltd | Manufacturing | 2018 |
| Design Lifecycle Limited | Information & communication | 1997 |
| Design Momentum Limited | Professional & scientific | 2015 |
| Design Seeder Ltd | Information & communication | 2026 |
| Desk Wise Limited | Manufacturing | 2004 |
| Deskora Ltd | Other services | 2025 |
| Desler Consulting Limited | Professional & scientific | 1993 |
| Desmo Concept Ltd | Wholesale & retail | 2024 |
| Destanie Enterprises Limited | Professional & scientific | 1998 |
| Detail Decorating Limited | Construction | 2018 |
| Devana Properties Limited | Construction | 2006 |