| Scholes Mcbride Ltd | Hospitality | 2023 |
| Scholes Properties LLP | | 2026 |
| School of Rock Lancashire Ltd | Education | 2025 |
| School Organiser Ltd | Education | 2024 |
| Schur-Bph Ltd | Manufacturing | 2006 |
| Scimitar Property Limited | Real estate | 2025 |
| SCM Recycling Limited | Water & waste | 2025 |
| Scopa Business Solutions Limited | Extraterritorial | 2020 |
| Scorpia Records Limited | Arts & recreation | 2006 |
| Scot Recycling Ltd | Water & waste | 2024 |
| Scotia Properties & Investments Ltd | Construction | 2024 |
| Scott Quigg Promotions Limited | Other services | 2011 |
| Scottie's Tearooms Ltd | Hospitality | 2024 |
| Scream Recovery Ltd | Wholesale & retail | 2023 |
| Scrubbers Clean Commercial Ltd | Administrative & support | 2008 |
| SCS HR Ltd | Information & communication | 2011 |
| Scst Holdings Ltd | Real estate | 2023 |
| SCV Group Ltd | Wholesale & retail | 2023 |
| SDC Leisure Ltd | Arts & recreation | 2025 |
| SDD Property Ltd | Real estate | 2023 |
| SDG Traders Ltd | Wholesale & retail | 2024 |
| SDH Accounting Services Ltd | Professional & scientific | 2021 |
| SDH Logistics Ltd | Transport & logistics | 2023 |
| SDZ (Chorley) Ltd | Agriculture & fishing | 2025 |
| Sea Sound Media Limited | Manufacturing | 2025 |
| Seablue Ltd | Information & communication | 2019 |
| Seabury Legal Limited | Other services | 2015 |
| Sealand Boat Deliveries Limited | Transport & logistics | 1972 |
| Sealhford Properties Limited | Real estate | 2021 |
| Searchmaster Ltd. | Information & communication | 1998 |
| Searchmode Limited | Professional & scientific | 2023 |
| Season Investment Ltd | Real estate | 2025 |
| Season to Taste Ltd | Hospitality | 2023 |
| Seatrex Limited | Extraterritorial | 2021 |
| Sebastian Majchrowski Ltd | Transport & logistics | 2016 |
| Secure Aluminium Limited | Construction | 2011 |
| Secure G.B Limited | Administrative & support | 2019 |
| Secure Licences Ltd | Professional & scientific | 2023 |
| Security and Fire Experts Limited | Administrative & support | 2009 |
| Security Risk Management and Consultants (UK) Limited | Professional & scientific | 2010 |
| Seddon Construction Services Ltd | Construction | 2025 |
| Seddons Trading Ltd | Administrative & support | 2015 |
| Sedgwick Goddard Ltd | Professional & scientific | 2007 |
| Seedfield Bowling Club Company,Limited | Arts & recreation | 1893 |
| Seedfield Designs Limited | Information & communication | 2021 |
| Seek Marketing Partners Ltd. | Information & communication | 2024 |
| Sefar Ltd | Wholesale & retail | 1985 |
| Sehnsa Catering Services Ltd | Hospitality | 2025 |
| Seicho Technology Solutions Ltd | Information & communication | 2026 |
| Seiko NW Ltd | Hospitality | 2024 |
| Select Dream Homes Limited | Real estate | 2022 |
| Select Leastone Limited | Other services | 2004 |
| Select Motor Spares (Bury) Ltd | Wholesale & retail | 2010 |
| Selected One Ltd | Wholesale & retail | 2014 |
| Self Khair CIC | Other services | 2025 |
| Sell Your Car in 60 Seconds Limited | Wholesale & retail | 2020 |
| Sella Interiors Ltd | Construction | 2025 |
| Sellcarinstant Ltd | Information & communication | 2026 |
| Sellermart Ltd | Wholesale & retail | 2022 |
| Semper Ltd | Professional & scientific | 2021 |
| Senafe Ltd | Wholesale & retail | 2020 |
| Send a HUG Ltd | Wholesale & retail | 2026 |
| Senior Waste Removals Ltd | Water & waste | 2015 |
| Sentinel Electrical Ltd | Construction | 2019 |
| Sentinel Engineering & Design Limited | Construction | 2023 |
| Sentinel Web Technologies Ltd | Information & communication | 2008 |
| Sequitur Consulting Limited | Health & social care | 2016 |
| Sercar Agricultural Ltd | Agriculture & fishing | 2022 |
| Seren Scripts Limited | Information & communication | 2014 |
| Serene House UK Limited | Wholesale & retail | 2010 |
| Serenity Oaks Care Ltd | Administrative & support | 2013 |
| Serkota Limited | Manufacturing | 2020 |
| Serlda Limited | Construction | 1934 |
| Service 700 Limited | Manufacturing | 2018 |
| Servtex Limited | Information & communication | 2018 |
| Ses-Online Limited | Wholesale & retail | 2020 |
| Seva Investment Limited | Extraterritorial | 2021 |
| Seven Construction Limited | Construction | 2009 |
| Seven Heavenz Cosmetics Ltd | Wholesale & retail | 2025 |
| Seven Stars Service Limited | Other services | 2015 |
| Seven Three Events Limited | Arts & recreation | 2026 |
| Seventh Disorder Ltd | Information & communication | 2025 |
| Sfcr Limited | Information & communication | 2018 |
| SFG Project Services Ltd | Information & communication | 2008 |
| SG Kentwood Consulting Ltd | Information & communication | 2019 |
| SG Services Hire Limited | Manufacturing | 2013 |
| SGM Fleet Support Limited | Wholesale & retail | 2019 |
| SGX Entertainment Limited | Arts & recreation | 2025 |
| SH Convenience Store Ltd | Wholesale & retail | 2026 |
| SH MCR Ltd | Real estate | 2025 |
| SH360 Ltd | Wholesale & retail | 2021 |
| Shack Wrap Ltd | Wholesale & retail | 2018 |
| Shadsworth Business Park Investments LLP | | 2006 |
| Shadsworth Property Investments LLP | | 2006 |
| Shaer Atelier Ltd | Other services | 2024 |
| Shah Building Solutions Ltd | Construction | 2014 |
| Shah Flooring Ltd | Construction | 2025 |
| Shah Motor Group Ltd | Wholesale & retail | 2023 |
| Shaheen Developments Ltd | Real estate | 2010 |
| Shaheen Foods Ltd | Wholesale & retail | 2015 |