| S&K Property Solutions NW Limited | Construction | 2025 |
| S&K UK Logistics Ltd | Transport & logistics | 2022 |
| S&N UK Logistics Ltd | Transport & logistics | 2022 |
| S&Qa Ltd | Wholesale & retail | 2026 |
| S&S Electrical Services (NW) Limited | Extraterritorial | 2020 |
| S&W Travels Ltd | Transport & logistics | 2019 |
| S. H. Enterprises (MCR) Ltd | Hospitality | 2017 |
| S.B Welder Ltd | Manufacturing | 2016 |
| S.C. Flats Management Limited | Households | 1971 |
| S.D.Woodcock Limited | Construction | 2005 |
| S.P. Rentals Limited | Real estate | 2016 |
| S.P.A. Sales Ltd | Wholesale & retail | 2025 |
| SA Clinical Services Limited | Professional & scientific | 2024 |
| Saba Ramsbottom Ltd | Hospitality | 2025 |
| Sabina Limited | Wholesale & retail | 2025 |
| Sabira Limited | Real estate | 2024 |
| SABT2 Limited | Hospitality | 2009 |
| Sacred Arts Foundation | Education | 2013 |
| Sadhaf Ahmed Ltd | Information & communication | 2019 |
| Sadiqpharma Ltd | Health & social care | 2024 |
| Sadlers (Lytham) Limited | Professional & scientific | 1946 |
| Saeedsultani Ltd | Wholesale & retail | 2022 |
| Safe Access and Platforms Limited | Construction | 2025 |
| Safe Automation & Gates Limited | Manufacturing | 2024 |
| Safe Build and Maintain Limited | Construction | 2023 |
| Safe Fabrication Limited | Manufacturing | 2025 |
| Safe Group Holdings Limited | Financial services | 2020 |
| Safe Place Solutions Limited | Wholesale & retail | 2023 |
| Safe Plant and Civils Limited | Construction | 2022 |
| Saferoof Solutions Ltd | Administrative & support | 2025 |
| Safety Management Consultants Ltd | Administrative & support | 2021 |
| Safeview Home Improvements Ltd | Construction | 2019 |
| SAI Care Limited | Real estate | 2015 |
| SAI Care Properties Limited | Real estate | 2020 |
| Saia Property Holdings Ltd | Real estate | 2026 |
| Saif Property Maintenance Ltd | Other services | 2022 |
| Saitek (UK) Limited | Professional & scientific | 2014 |
| SAJ Security Limited | Administrative & support | 2022 |
| Sajjuna Ltd | Transport & logistics | 2025 |
| Sajjuna Property & Investment Ltd | Real estate | 2025 |
| Salary Sacrifice Car Scheme Limited | Financial services | 2025 |
| Saleemi Enterprise Ltd | Real estate | 2018 |
| Sales Angels Services Ltd | Administrative & support | 2024 |
| Salford Waste Services Limited | Extraterritorial | 2016 |
| Salient Group Ltd | Professional & scientific | 2018 |
| Salisbury & Sons Ltd | Real estate | 2025 |
| Salon Refreshed Limited | Other services | 2022 |
| Salvatores Pizza Ltd | Hospitality | 2025 |
| SAM Express Ltd | Hospitality | 2019 |
| SAM GUY Creative Ltd | Professional & scientific | 2025 |
| SAM Properties Limited | Real estate | 2003 |
| Samantha Ainsworth Legal Limited | Professional & scientific | 2023 |
| Sambogdan Ltd | Transport & logistics | 2016 |
| Sams 313 Ltd | Real estate | 2024 |
| Samson Collier Ltd | Professional & scientific | 2021 |
| Samuel Cooke & Co Limited | Extraterritorial | 2012 |
| Samuel J Commercials Limited | Wholesale & retail | 2025 |
| SAN Plan Limited | Professional & scientific | 2021 |
| Sanctuary Therapy Centre Ltd | Professional & scientific | 2024 |
| Sandala Safety Solutions Ltd | Professional & scientific | 2018 |
| Sandifords Retouch Studio Limited | Professional & scientific | 2022 |
| Sandown Properties (NW) Ltd | Real estate | 2019 |
| Sandy Lane (Management Company) Limited | Households | 2006 |
| Santa-Fe Pipe Services Ltd | Professional & scientific | 2012 |
| Santali Properties Ltd | Real estate | 2020 |
| Santora Limited | Extraterritorial | 2021 |
| Santos Art Ltd | Other services | 2023 |
| Santra Housing Providers Ltd | Real estate | 2022 |
| Saphire Property Consultants (SPC) Ltd | Construction | 2021 |
| Sapphire Flat 604 Ltd | Real estate | 2023 |
| Sapphire Glazing Ltd | Manufacturing | 2021 |
| Sarsawa Takeaway&Catering Ltd | Hospitality | 2024 |
| Sarsfield Residential Ltd | Real estate | 2020 |
| Sartex Limited | Extraterritorial | 2024 |
| Sarwari Ltd | Wholesale & retail | 2022 |
| Sasco Associates Limited | Extraterritorial | 2021 |
| Saturn Facilities Group Ltd | Administrative & support | 2022 |
| Saturn Super Distribution Limited | Administrative & support | 1994 |
| Savannah Property Developments Ltd | Real estate | 2021 |
| Savershop Limited | Wholesale & retail | 2024 |
| Savvy Models Limited | Other services | 2013 |
| Savvy Property Management Limited | Real estate | 2020 |
| Savvylash Ltd | Wholesale & retail | 2005 |
| Sawadee Thai Dining Ltd | Hospitality | 2025 |
| Sawcz.Uk Ltd | Information & communication | 2017 |
| Sayyed Aqib Ltd | Public administration | 2021 |
| Sbaa Academy Ltd | Arts & recreation | 2016 |
| Sbft NW Ltd | Hospitality | 2024 |
| SBG Bury Limited | Arts & recreation | 2022 |
| SBH Pharma Ltd | Health & social care | 2023 |
| SBL Camden 22 Ltd | Information & communication | 2000 |
| SBM Agency Limited | Education | 2019 |
| SC Autotex Ltd | Wholesale & retail | 2025 |
| Scarhill Properties Ltd | Construction | 2025 |
| SCC Luxury Cars Ltd | Wholesale & retail | 2020 |
| Scentroyale Ltd | Wholesale & retail | 2025 |
| Schilter Limited | Real estate | 2010 |
| Scholes Electrical Services (NW) Ltd | Construction | 2023 |
| Scholes Estates Limited | Real estate | 2026 |
| Scholes Hand Car Wash Ltd | Administrative & support | 2025 |