| Shahzad Optical Ltd | Professional & scientific | 2014 |
| Shahzoor & Sons Properties Limited | Households | 2024 |
| Shah’S Indian Ltd | Hospitality | 2026 |
| Shalkel Property Management & Development Limited | Real estate | 2019 |
| Shammi Rouf Implants Ltd | Health & social care | 2023 |
| Shamz Courier Service Ltd | Transport & logistics | 2025 |
| Shanevach Limited | Construction | 2024 |
| Shanishah Limited | Professional & scientific | 2019 |
| Shaped by Emily Ltd | Health & social care | 2023 |
| Shaped Co. Medical Spa Ltd | Other services | 2023 |
| Shaq Chippy Limited | Hospitality | 2025 |
| Sharda Limited | Wholesale & retail | 2014 |
| Shark Analytics Limited | Administrative & support | 2025 |
| Shark CUT Ltd | Wholesale & retail | 2024 |
| Sharmar Developments Ltd | Real estate | 2022 |
| Sharp Tech Consultancy Services Ltd | Information & communication | 2016 |
| Shaw Lodge Management Company Limited | Households | 2006 |
| Shaw Tech Solutions Ltd | Administrative & support | 2021 |
| Shazia's Catering & Takeaway Services Limited | Hospitality | 2024 |
| Shazia's Street Food Limited | Hospitality | 2016 |
| SHC Gifting Limited | Real estate | 2022 |
| SHD Lighting Consultancy Limited | Professional & scientific | 2019 |
| Sheeba Riaz Limited | Education | 2014 |
| Sheep HEY Management Company Limited | Households | 2010 |
| Shek Tech Limited | Wholesale & retail | 2024 |
| Shellbys Investments Ltd | Construction | 2025 |
| Shellco 142 Limited | Real estate | 2014 |
| Shelley Bailey Care Ltd | Health & social care | 2021 |
| Sheppylee Consultancy Ltd | Health & social care | 2025 |
| Sheridan Bar Investments Limited | Hospitality | 2015 |
| Sheridan Construction Manchester Limited | Construction | 2025 |
| Sheridan FM Limited | Construction | 2025 |
| Sheridan Group Lift Services Ltd | Professional & scientific | 2025 |
| Sheridan Property Group Ltd | Construction | 2023 |
| Sheridan Waste Managment Limited | Water & waste | 2025 |
| Sheridans Construction Ltd | Construction | 2025 |
| Sherwood(Uk) Limited | Other services | 2007 |
| Shibusa Consultancy Limited | Transport & logistics | 2014 |
| Shift G Ltd | Professional & scientific | 2023 |
| Shifters Waste Removal Ltd | Water & waste | 2025 |
| Shine & Refresh Ltd | Administrative & support | 2023 |
| Shine Double Glazzing Limited | Manufacturing | 2016 |
| Shine Fashions Ltd | Manufacturing | 2022 |
| Shine Source Footwear (UK) Ltd | Wholesale & retail | 2016 |
| Shipsave Ltd | Administrative & support | 2022 |
| Shiraz Market & Bakery Ltd | Wholesale & retail | 2026 |
| Shiredale Homes Limited | Construction | 2004 |
| SHM Media Ltd | Professional & scientific | 2023 |
| Shohab Salim Limited | Professional & scientific | 2013 |
| Shomron Associates Limited | Professional & scientific | 2011 |
| Shop Ondemand Ltd | Wholesale & retail | 2020 |
| Shopiver Ltd | Wholesale & retail | 2025 |
| Shoplane Ltd | Wholesale & retail | 2026 |
| Shopsavvyuk Limited | Wholesale & retail | 2024 |
| SHOPSTORE24 Ltd | Wholesale & retail | 2025 |
| Shoptok MCR Limited | Wholesale & retail | 2024 |
| Shopzio Ltd | Wholesale & retail | 2025 |
| Showcase Media Productions Ltd | Information & communication | 2017 |
| Showtime Fabrications Ltd | Manufacturing | 2025 |
| Shuku Aura Limited | Other services | 2026 |
| Sian Miller Aesthetics Ltd | Other services | 2026 |
| Sians Properties Ltd | Households | 2022 |
| Sibsco Limited | Other services | 2019 |
| Sicamour Creations Ltd | Wholesale & retail | 2023 |
| Side Street Burgers Ltd | Hospitality | 2019 |
| Sideways Sound Limited | Information & communication | 2014 |
| Sidewinder Global Ltd | Wholesale & retail | 2024 |
| Sidr Productions Limited | Education | 2025 |
| Sienco Holdings Limited | Professional & scientific | 2018 |
| Sign Print Design Limited | Manufacturing | 2018 |
| Signal Electronic Systems Limited | Construction | 2016 |
| Signature Conveyancing Limited | Administrative & support | 2026 |
| Signature Funerals Ltd | Other services | 2018 |
| SIGNING4SILENCE Limited | Professional & scientific | 2025 |
| Silcock Brothers Ltd | Arts & recreation | 2015 |
| Silentpeak Solutions Ltd | Construction | 2024 |
| Silicon Web and Graphic Design Ltd | Information & communication | 2025 |
| Silver Key Lettings Ltd | Real estate | 2025 |
| Silverfox Management Group Ltd | Professional & scientific | 2022 |
| Silverlink Investments Limited | Real estate | 2025 |
| Silverwell Home Care Services Ltd | Health & social care | 2022 |
| Silverworth Ltd | Transport & logistics | 2019 |
| Simber Consulting Group Limited | Professional & scientific | 2020 |
| Simply Auto Enrolment Solutions Limited | Financial services | 2013 |
| Simply Pensions Ltd | Financial services | 2001 |
| Simply Review UK Ltd | Construction | 2020 |
| Simply Rewards Limited | Financial services | 2017 |
| Simply Smiles Manchester Ltd | Health & social care | 2009 |
| Simply Wills and Probate Ltd | Other services | 2024 |
| Simpsons Food Ltd | Hospitality | 2023 |
| Simran and Ayaan Ltd | Wholesale & retail | 2025 |
| Singer & Friedlander Bridging Finance Limited | Financial services | 2025 |
| Singer & Friedlander Property Finance Limited | Financial services | 2025 |
| Singer & Friedlander Specialised Finance Limited | Financial services | 2025 |
| Sintifex Solutions Ltd | Information & communication | 2026 |
| SIR Cleans a LOT Window Cleaning Services Limited | Administrative & support | 2017 |
| Sirius Software and Development Ltd | Information & communication | 2025 |
| Sisz Limited | Wholesale & retail | 2014 |
| Site Engineering Works Limited | Professional & scientific | 2024 |
| Site Movements UK Limited | Transport & logistics | 2017 |