| Smith Pubs Limited | Hospitality | 2012 |
| Smith’S Yard Garage Ltd | Wholesale & retail | 2024 |
| SMJ Transport Ltd | Transport & logistics | 2023 |
| Smkd Imports Ltd | Wholesale & retail | 2013 |
| Smna Medics Ltd | Health & social care | 2025 |
| Smsnorthernproperty Ltd | Real estate | 2025 |
| SMT Developments Ltd | Real estate | 2020 |
| SMT Electrical Services Ltd | Construction | 2015 |
| SN Clothing UK Limited | Wholesale & retail | 2018 |
| SN Consult Limited | Professional & scientific | 2014 |
| SN Pizza Burnley Ltd | Hospitality | 2025 |
| Snft Limited | Wholesale & retail | 2025 |
| SNJ Cargo Limited | Transport & logistics | 2022 |
| Snowshill Allied Holdings Limited | Professional & scientific | 1983 |
| SNS Couriers Ltd | Transport & logistics | 2020 |
| SNS Furniture Ltd | Manufacturing | 2025 |
| Snuff Limited | Wholesale & retail | 2007 |
| Social Rebuild Ltd | Professional & scientific | 2021 |
| Sofa Smart Interiors Ltd | Wholesale & retail | 2018 |
| Sofbella Automotive Group Limited | Financial services | 2020 |
| Soft Priced Hardware Limited | Wholesale & retail | 2002 |
| Softly Does IT Limited | Information & communication | 2002 |
| Sohail Clinical Services Ltd | Health & social care | 2025 |
| Soho DB Ltd | Arts & recreation | 2025 |
| Sohr Ltd | Wholesale & retail | 2014 |
| Sokar Valley Limited | Other services | 2019 |
| Solar Plus Installations Limited | Construction | 2026 |
| Solar Safeguard (NW) Ltd | Manufacturing | 2016 |
| Solidseal Ltd | Construction | 2024 |
| Solvra Global Ltd | Information & communication | 2026 |
| Sonara Health Ltd | Health & social care | 2025 |
| Sonifar Pharma Expert Limited | Manufacturing | 2017 |
| Sonna Kitchens Ltd | Wholesale & retail | 2019 |
| Sonya Little Store Ltd | Wholesale & retail | 2023 |
| Soosa Ltd | Hospitality | 2023 |
| Sorsco Consultancy Limited | Professional & scientific | 2019 |
| SOS Handyman Property Maintenance and Home Improvement Limited | Construction | 2013 |
| Southern Carburetters Limited | Wholesale & retail | 1989 |
| Southerns Property Limited | Real estate | 2024 |
| Southerns Solicitors Limited | Professional & scientific | 2013 |
| Southey Interiors Limited | Wholesale & retail | 2003 |
| SP Burnley Ltd | Hospitality | 2024 |
| SP Nelson Ltd | Hospitality | 2024 |
| SP Padiham Ltd | Hospitality | 2024 |
| SP Rotherham Ltd | Hospitality | 2025 |
| SP Scans Ltd | Health & social care | 2024 |
| Space Digital Limited | Administrative & support | 2006 |
| Spacily Limited | Other services | 2012 |
| Spacious Place Construct Ltd | Construction | 2014 |
| Spacious Place Contact Ltd | Health & social care | 2014 |
| Spacious Place Enterprises Ltd | Health & social care | 2014 |
| Sparescheme Limited | Construction | 1994 |
| Sparky Electrical Ltd | Construction | 2025 |
| Sparta AE Limited | Manufacturing | 2025 |
| Sparta Limited | Manufacturing | 1991 |
| Spartax Monitoring Services Ltd | Administrative & support | 2026 |
| Spartax Solution Ltd | Administrative & support | 2022 |
| Spartax Training & Management Ltd | Administrative & support | 2026 |
| Spatial Properties Limited | Real estate | 2008 |
| Spchr Ltd | Construction | 2019 |
| Spcs Care Ltd | Health & social care | 2025 |
| Spcw Ltd | Construction | 2019 |
| SPE Furnishings Ltd | Health & social care | 2015 |
| Speakman & Sons Precise Developments Ltd | Construction | 2012 |
| Speakman Contractors Ltd | Construction | 2009 |
| Spectrum Global Network Limited | Information & communication | 2024 |
| Spgbrit Limited | Other services | 2019 |
| Spherical Software Limited | Information & communication | 2013 |
| Spin Venture Partners Ltd | Professional & scientific | 2020 |
| Spootless Ltd | Wholesale & retail | 2024 |
| Spotlight Detailing Ltd | Other services | 2026 |
| Springbrook Limited | Wholesale & retail | 1969 |
| Spudzy’S Ltd | Hospitality | 2025 |
| Square & Compass (NW) Ltd | Construction | 2018 |
| Square & Compass Group Ltd | Financial services | 2025 |
| Squeaky Clean Services Limited | Administrative & support | 2024 |
| Squirrel Energy Generation 1 Ltd | Energy | 2021 |
| Squirrel Energy Group Ltd | Construction | 2013 |
| Squirrel Energy Limited | Construction | 2021 |
| Squirrel Energy Services Ltd | Construction | 2020 |
| Squirrel Energy Solar Ltd | Construction | 2020 |
| SR Consultancy Limited | Professional & scientific | 2021 |
| SRS247 Ltd | Wholesale & retail | 2025 |
| SS Medical Healthcare Ltd | Health & social care | 2018 |
| Ss&B Limited | Manufacturing | 2025 |
| Ssdd Limited | Information & communication | 2008 |
| Ssfi Limited | Health & social care | 2011 |
| Sshr Ltd | Health & social care | 2010 |
| Ssmart Investments Ltd | Real estate | 2019 |
| Ssyns Limited | Health & social care | 2019 |
| ST Albans Digital Media Ltd | Information & communication | 2014 |
| ST James Sports & Enterprise Academy Ltd | Education | 2020 |
| ST Ninians Church Bute Ltd | Real estate | 2020 |
| ST Osmunds Community Nursery Limited | Education | 2002 |
| ST Solutions (NW) Limited | Construction | 2017 |
| ST. George's Construction Limited | Construction | 1998 |
| Stanbury Consultancy Limited | Professional & scientific | 2014 |
| Standish Street Dental Ltd | Health & social care | 2015 |
| Stanworth Law Limited | Professional & scientific | 2021 |
| Stanworth Property Holdings Limited | Real estate | 2024 |