| Stanworths Ltd | Wholesale & retail | 2024 |
| Star Barber NW Ltd | Other services | 2022 |
| Star Cafe (Burnley) Ltd | Hospitality | 2015 |
| Stars Transport Ltd | Transport & logistics | 2023 |
| Start Media Services Ltd | Administrative & support | 2017 |
| Stawrex Brands INT Ltd | Wholesale & retail | 2024 |
| Stay at Bowland Forest Ltd | Hospitality | 2025 |
| Staystrong Transport Services Ltd | Transport & logistics | 2016 |
| Stazcare Ltd | Health & social care | 2017 |
| Stazcarehomes Ltd | Administrative & support | 2020 |
| Steam Training Club Ltd | Arts & recreation | 2015 |
| Stella Experts Limited | Hospitality | 2012 |
| Steon Holdings Ltd | Manufacturing | 2016 |
| Steon Ltd | Manufacturing | 1971 |
| Stepford Apparel Ltd | Wholesale & retail | 2025 |
| Steph Cole Occupational Therapy Ltd | Health & social care | 2020 |
| Sterling Trade Group Ltd | Wholesale & retail | 2026 |
| Steve Durkin Vehicle Services Limited | Wholesale & retail | 2002 |
| Steve Swales Dairy Limited | Agriculture & fishing | 2013 |
| Steve's Automotive Spares Limited | Wholesale & retail | 2025 |
| Steven Wiggin Electrical Installations Limited | Construction | 2025 |
| Stewart Chanter Ltd | Wholesale & retail | 2009 |
| STF Solutions Limited | Construction | 2007 |
| Stockleys Sweets Limited | Manufacturing | 2009 |
| Stolle EMS Group Limited | Financial services | 2013 |
| Stolle Machinery UK Ltd | Manufacturing | 2008 |
| Stone Made Driveways Ltd | Administrative & support | 2020 |
| Stonehaven Properties Ltd | Real estate | 2020 |
| Stonehill Nurseries & Garden Centre Limited | Wholesale & retail | 1996 |
| Stonevale Property Management Limited | Real estate | 2025 |
| Stoneyhealth Limited | Health & social care | 2015 |
| Stoneyhurst Enterprises (Holdings) Limited | Professional & scientific | 2022 |
| Stop Shop Ltd | Wholesale & retail | 2014 |
| Store First Limited | Extraterritorial | 2024 |
| Store First Self Storage Ltd | Real estate | 2019 |
| Store First ST Helens Limited | Real estate | 2015 |
| Storm Live AGE Ltd | Wholesale & retail | 2025 |
| Stoudemire International Ltd | Financial services | 2026 |
| Straitsvale Ltd | Real estate | 2024 |
| Strawberry Enterprise Limited | Information & communication | 2010 |
| Street CAM Limited | Manufacturing | 1999 |
| Street Kitchen Limited | Hospitality | 2025 |
| Street Machine Limited | Wholesale & retail | 2026 |
| Streetbiteskitchen Ltd | Hospitality | 2024 |
| Stretched & Fired Operations Ltd | Hospitality | 2022 |
| Strikeprosupplies Ltd | Manufacturing | 2024 |
| Striking Features Ltd | Information & communication | 2016 |
| String Invest Ltd | Real estate | 2024 |
| Stronger Things Ltd | Wholesale & retail | 2026 |
| Stronghouse Limited | Real estate | 2015 |
| Structural Coating Solutions Ltd | Construction | 2025 |
| STS Manufacturing Limited | Professional & scientific | 2003 |
| Stsaa Ltd | Wholesale & retail | 2026 |
| Stuart Surridge & Company Limited | Wholesale & retail | 2011 |
| Study Consultants Limited | Education | 2021 |
| Style Residence Ltd | Other services | 2004 |
| Sudall Property Services Ltd | Wholesale & retail | 2026 |
| Sufi TV Limited | Information & communication | 2013 |
| Sugar Lettings Limited | Real estate | 2024 |
| Suldia Ltd | Wholesale & retail | 2025 |
| SULEMAN7 Limited | Wholesale & retail | 2026 |
| Sullivan's Properties Ltd | Real estate | 2025 |
| Sultan Real Estate Limited | Real estate | 2025 |
| Sumbuls Kebab Ltd | Hospitality | 2026 |
| Sumf Limited | Construction | 2025 |
| Summit Asset Ventures Ltd | Wholesale & retail | 2026 |
| Summit Auto Bodies Limited | Wholesale & retail | 2012 |
| Summit Recycling Solutions Ltd | Wholesale & retail | 2023 |
| Summit Sourcing Ltd | Wholesale & retail | 2025 |
| Sun & Skewers Limited | Wholesale & retail | 2023 |
| Sunkiss Tanning Studio Ltd | Other services | 2024 |
| Sunkissed Glow Sunbeds Ltd | Other services | 2026 |
| Sunny (NW) Ltd | Other services | 2022 |
| Sunny Dealers Ltd | Wholesale & retail | 2024 |
| Sunnydale Support Services Limited | Administrative & support | 2024 |
| Sunray Pubs Limited | Other services | 2020 |
| Sunshine Roofers Ltd | Construction | 2020 |
| Suntec Blinds Retail Limited | Wholesale & retail | 2011 |
| Supashed Rochdale Limited | Construction | 2019 |
| Super CUT Burnley Ltd | Other services | 2019 |
| Super Mario Cleaning Service Ltd | Administrative & support | 2026 |
| Super Pound Plus Store (Burnley) Ltd | Wholesale & retail | 2019 |
| SUPER328 Limited | Hospitality | 2013 |
| Superdry Roofing Limited | Construction | 2017 |
| Superspec Associates Limited | Real estate | 2000 |
| Support R US Limited | Administrative & support | 2023 |
| Sureguard Security Solutions Ltd | Administrative & support | 2023 |
| Surevac Ltd | Manufacturing | 2016 |
| Sureway Civil Engineering Limited | Professional & scientific | 2013 |
| Sureway Groundwork Ltd | Construction | 2006 |
| Sureway Site Contractors Limited | Extraterritorial | 2014 |
| Surge Properties Ltd | Construction | 2020 |
| Surteco UK Limited | Manufacturing | 1961 |
| Suruchi Express Takeaway Ltd | Hospitality | 2026 |
| Suruchi Indian Takeaway Ltd | Hospitality | 2025 |
| Sussex Pallet Services Ltd | Transport & logistics | 2016 |
| Sustainable Interiors Ltd | Wholesale & retail | 2015 |
| Sustainable Projects Limited | Administrative & support | 2016 |
| Suzannah Celik Laser and Skin Clinic Ltd | Other services | 2024 |
| Suzannes of Colne Ltd | Wholesale & retail | 2012 |