| Shaney Store Ltd | Wholesale & retail | 2022 |
| Shangrila City Limited | Real estate | 2025 |
| Sharif Ventures Ltd | Wholesale & retail | 2024 |
| Sharp Hydrographic Limited | Construction | 2012 |
| Shaw`S Builders Limited | Construction | 2004 |
| Shears Red 5 Ltd | Wholesale & retail | 2019 |
| Sheni Ltd | Wholesale & retail | 2025 |
| Sherafza Ltd | Health & social care | 2016 |
| Sherex Fastening Solutions UK Ltd | Wholesale & retail | 2019 |
| Sherlock Media Group Ltd | Professional & scientific | 2024 |
| Shifah Global Limited | Wholesale & retail | 2025 |
| Shilayan Automotive UK Limited | Manufacturing | 2005 |
| Shinwari Mehfil Ltd | Hospitality | 2026 |
| Shipstons of Sabden Limited | Extraterritorial | 2013 |
| Shoo Frenzy Ltd | Wholesale & retail | 2025 |
| Shop at Bowland Forest Ltd | Wholesale & retail | 2025 |
| Shop Local Padiham Limited | Wholesale & retail | 2025 |
| Shop Reed Ltd | Wholesale & retail | 2025 |
| Shopaholic Limited | Wholesale & retail | 2020 |
| Shopbloom Ltd | Wholesale & retail | 2025 |
| Shoporo Ltd | Wholesale & retail | 2026 |
| Shoppiko Ltd | Wholesale & retail | 2025 |
| Shoukat Developments Ltd | Construction | 2025 |
| SHP Group Limited | Real estate | 2017 |
| Sial Legal Services Limited | Professional & scientific | 2026 |
| Siam Thrive Kitchen Limited | Hospitality | 2025 |
| Sibel Varna Ltd | Hospitality | 2026 |
| Sick Cars Ltd | Wholesale & retail | 2026 |
| Sign Options Limited | Administrative & support | 2004 |
| Sign to Communicate Ltd | Education | 2024 |
| Signature Atelier Ltd | Wholesale & retail | 2026 |
| Signature Joinery Limited | Other services | 2013 |
| Silotea Limited | Wholesale & retail | 2024 |
| Silver Slingshot Ltd | Wholesale & retail | 2024 |
| Silverback Construction NW Ltd | Construction | 2024 |
| Silverback Signage Ltd | Construction | 2026 |
| Silverpoint Operations Consulting Ltd | Professional & scientific | 2026 |
| Silverstone Accountancy Ltd | Professional & scientific | 2021 |
| Simbar Construction Ltd | Construction | 2024 |
| Simka Beauty Ltd | Other services | 2025 |
| Simm Property Developments Limited | Construction | 2024 |
| Simm Property Investments Limited | Real estate | 2022 |
| Simmvest Limited | Professional & scientific | 2025 |
| Simonstone Engineering Ltd | Professional & scientific | 2014 |
| Simply Corporate Group Limited | Financial services | 2018 |
| Simply Corporate Limited | Financial services | 2018 |
| Simply Marquees Ltd | Hospitality | 2020 |
| Simply Secure Training Ltd | Education | 2022 |
| Simply Spuds Ltd | Hospitality | 2026 |
| Simplysecuregroup Ltd | Administrative & support | 2020 |
| Singleton Engineering Solutions Ltd | Professional & scientific | 2015 |
| Singletrack Distribution Limited | Wholesale & retail | 2015 |
| Sirca Properties Ltd | Real estate | 2023 |
| Sitesafe Electrical Testing Ltd | Construction | 2025 |
| SIX Connections Community C.I.C. | Health & social care | 2020 |
| SIX Connections Limited | Education | 2020 |
| Sixth Reason Investments Limited | Real estate | 2020 |
| Sizzleandsweet Ltd | Hospitality | 2026 |
| SJ Aakash Limited | Wholesale & retail | 2025 |
| SJA MED Limited | Health & social care | 2021 |
| SJD Consultancy Ltd | Information & communication | 2015 |
| SJG Developments Limited | Construction | 2006 |
| SJL Business Services Ltd | Real estate | 2015 |
| SK & Associates Limited | Wholesale & retail | 2001 |
| SK Training & Management Ltd | Administrative & support | 2026 |
| SKE Ltd | Information & communication | 2014 |
| SKH Investments Ltd | Real estate | 2020 |
| Skills Mastery Limited | Education | 2013 |
| Skipton Health Care Ltd | Administrative & support | 2015 |
| Skipton Skip Hire Ltd | Water & waste | 2021 |
| Skoon Candles Ltd | Manufacturing | 2025 |
| SKS Storage Ltd | Transport & logistics | 2025 |
| Skyline Flex Ltd | Wholesale & retail | 2026 |
| Skyline Integrated Facilities Management Ltd | Administrative & support | 2020 |
| Skynet Motor Sports Ltd | Construction | 2014 |
| Skyways Motors Limited | Wholesale & retail | 2025 |
| SL Bfpm Ltd | Transport & logistics | 2026 |
| Slaters Distribution Ltd | Transport & logistics | 2017 |
| SLE Care Services Limited | Public administration | 2015 |
| Sleeps 12 Plus Limited | Real estate | 2021 |
| Slice & Co UK Limited | Hospitality | 2025 |
| Slickwhips Ltd | Wholesale & retail | 2020 |
| Slurry Pump Services Limited | Wholesale & retail | 2003 |
| SM Network Services Ltd | Information & communication | 2017 |
| Small and Mighty Babies Limited | Manufacturing | 2019 |
| Smart Chocolate Limited | Wholesale & retail | 2023 |
| Smart Choice Point Limited | Wholesale & retail | 2025 |
| Smart Conclusions Ltd | Administrative & support | 2007 |
| Smart Flooring Ltd | Construction | 2024 |
| Smart Garment People Limited | Administrative & support | 2007 |
| Smart Price Home Store Ltd | Wholesale & retail | 2018 |
| Smart Property Ventures Ltd | Real estate | 2020 |
| Smart Scent Group Ltd | Hospitality | 2024 |
| Smart Services 4YOU Ltd | Other services | 2024 |
| Smart Workwear Outlet Limited | Wholesale & retail | 2023 |
| Smartclean North West Limited | Other services | 2017 |
| Smartfixmobiletyres Ltd | Wholesale & retail | 2025 |
| Smartshop 24HOUR (2) Ltd | Wholesale & retail | 2025 |
| SME Contractors Limited | Construction | 2022 |
| Smile Mediation Ltd | Other services | 1998 |