| Salplex Limited | Wholesale & retail | 2026 |
| Salva - Burnley Limited | Hospitality | 2024 |
| Salva Eats Ltd | Information & communication | 2023 |
| Samco Property Ltd | Real estate | 2019 |
| Sammon Estates Limited | Construction | 2003 |
| Samsonz Trading Ltd | Wholesale & retail | 2021 |
| Sand Hairdressing Limited | Other services | 2003 |
| Sanderson Contractors Ltd | Construction | 2020 |
| Sanderson Steel Structures Ltd | Professional & scientific | 2021 |
| Sands Burnley Ltd | Hospitality | 2025 |
| Sandwood Group Limited | Financial services | 2026 |
| Sandygate Cars Ltd | Wholesale & retail | 2014 |
| Sandygate Sports Bar Ltd | Arts & recreation | 2023 |
| Sapfi Ltd | Professional & scientific | 2015 |
| Sapling Green Farm School & Nursery Ltd | Education | 2024 |
| Sapphia Trading Ltd | Wholesale & retail | 2016 |
| Sardarji Store Limited | Wholesale & retail | 2026 |
| Sarfraz Enterprise Limited | Wholesale & retail | 2026 |
| SAS Store Private Ltd | Wholesale & retail | 2025 |
| Satippers Ltd | Manufacturing | 2025 |
| Satisfix Ltd | Construction | 2017 |
| Saturn Management Entertainment & Leisure Ltd | Hospitality | 2025 |
| Saul Parker Design Consultants Ltd | Professional & scientific | 2004 |
| Saversclick Ltd | Wholesale & retail | 2020 |
| SAW Doctors Forestry Ltd | Agriculture & fishing | 2017 |
| SB 7 Property Limited | Real estate | 2018 |
| SB Lettings NW Ltd | Real estate | 2018 |
| SB Music Limited | Information & communication | 2021 |
| SB Real Estate Limited | Real estate | 2008 |
| SBK Priya & Co Limited | Wholesale & retail | 2022 |
| Sblb Limited | Wholesale & retail | 2025 |
| SBS Electrical, Heating & Plumbing Services Limited | Construction | 1998 |
| SC Medical (Lancs) Limited | Health & social care | 2023 |
| Scalje Limited | Information & communication | 2013 |
| Scalyzon Ltd | Wholesale & retail | 2025 |
| Schoolwear Direct Ltd | Wholesale & retail | 2025 |
| Scion Group Holdings Ltd | Financial services | 2026 |
| Scion Labs Ltd | Professional & scientific | 2026 |
| Scofers Property Development Ltd | Real estate | 2020 |
| Scope Electrical Engineering Ltd | Manufacturing | 2025 |
| Scope Fire and Security Ltd | Other services | 2019 |
| Scoped Solutions Ltd | Information & communication | 2009 |
| Scoria Investments 1 Ltd | Real estate | 2025 |
| Scott Dawson Advertising Limited | Professional & scientific | 1990 |
| Scottilling Ltd | Professional & scientific | 2017 |
| Scrim an Skim Finishing Ltd | Construction | 2025 |
| SCS European (Burnley) Ltd | Transport & logistics | 2011 |
| Sculpt Reformer Ltd | Arts & recreation | 2026 |
| SDB Haulage Ltd | Transport & logistics | 2018 |
| SDL Group (2025) Holdings Limited | Financial services | 2025 |
| SDM Express Cuisine Ltd | Hospitality | 2026 |
| Sean Parker Haulage Limited | Transport & logistics | 2019 |
| Sean Thomas Construction Ltd | Construction | 2017 |
| Seaways Services (U.K.) Holdings Limited | Professional & scientific | 2011 |
| Secondsole Ltd | Wholesale & retail | 2026 |
| SEE Thru Windows Ltd | Wholesale & retail | 2024 |
| Seeds of Dawn Ltd | Administrative & support | 2026 |
| Seertek Ltd | Professional & scientific | 2015 |
| Sehl Marketing and Business Support Functions Ltd | Extraterritorial | 2026 |
| Sehnsa Properties Ltd | Real estate | 2024 |
| Selby Property Ltd | Real estate | 2020 |
| Select Facades Limited | Construction | 2005 |
| Select Marketing (Northwest) Ltd | Administrative & support | 1999 |
| Sell UK Property Ltd | Real estate | 2018 |
| Semantrix Sessions, Ltd. | Education | 2022 |
| Sensible Price Car & Van Hire Limited | Administrative & support | 1994 |
| Sensuous Ltd | Other services | 2026 |
| Sepulchre Limited | Real estate | 2000 |
| Serene Homes North Limited | Real estate | 2019 |
| Serene Lettings Ltd | Households | 2024 |
| Serene North Holdings Limited | Real estate | 2025 |
| Serene Slumber Essentials Ltd | Wholesale & retail | 2024 |
| Serenity Pilates Studios Ltd | Arts & recreation | 2025 |
| Seriun Communications Limited | Information & communication | 2013 |
| Seriun Consultancy Limited | Information & communication | 2000 |
| Seriun Holdings Limited | Financial services | 2024 |
| Seriun Limited | Information & communication | 2003 |
| Service Alliance Limited | Administrative & support | 2005 |
| Seven Sisters Music Ltd. | Information & communication | 2016 |
| Sevilla Ltd | Wholesale & retail | 2026 |
| SFX Tiling Contractors Ltd | Construction | 2016 |
| SFX Trading Ltd | Financial services | 2021 |
| SGH Architects Limited | Professional & scientific | 2020 |
| SH Tech Limited | Information & communication | 2026 |
| Sh&F Properties Ltd | Real estate | 2025 |
| Shabz & a Limited | Wholesale & retail | 2025 |
| Shades N Space Ltd | Construction | 2025 |
| Shafer Ltd | Wholesale & retail | 2022 |
| Shafi Properties Ltd | Real estate | 2019 |
| Shafi Traders Limited | Wholesale & retail | 2025 |
| Shagor Indian Takeaway Ltd | Hospitality | 2026 |
| Shah Global Health Consulting Ltd | Professional & scientific | 2025 |
| Shah Ventures Group Ltd | Financial services | 2024 |
| Shaheen Snuff Ltd | Other services | 2019 |
| Shaheen Trading Ltd | Wholesale & retail | 2026 |
| Shakira Khan Ltd | Professional & scientific | 2026 |
| Shaks Autos Limited | Wholesale & retail | 2024 |
| Shalimar Traders Ltd | Wholesale & retail | 2023 |
| Shama Proper T Ltd | Real estate | 2025 |
| Shaney Ltd | Wholesale & retail | 2020 |