| Spring Tooling Limited | Manufacturing | 1974 |
| Spring View Care Limited | Health & social care | 2012 |
| Sproule Developments Ltd | Construction | 2021 |
| SPS Property Management Group Ltd | Real estate | 2023 |
| Square PEG Recruitment South Limited | Administrative & support | 2008 |
| Squareye Television Limited | Information & communication | 2003 |
| Squid Fit Ltd | Arts & recreation | 2024 |
| Squire Plus Ltd | Hospitality | 2024 |
| SR BG Ltd | Hospitality | 2025 |
| SRH RC Limited | Wholesale & retail | 2026 |
| SRI SAI Shiva Private Limited | Wholesale & retail | 2015 |
| SRK Private Limited | Wholesale & retail | 2023 |
| SRR Europa Building Ltd | Real estate | 2023 |
| Sshj Group Limited | Real estate | 2026 |
| ST Catherines Consulting Limited | Real estate | 2023 |
| ST Helen's Place Management Company Limited | Households | 2025 |
| ST Johns Asset Management Limited | Financial services | 2003 |
| ST Laurence Meadows Management Company Limited | Households | 2016 |
| ST Lisaj Limited | Administrative & support | 2013 |
| ST Lisaj Property Limited | Real estate | 2023 |
| ST Oswalds Close Management Company Limited | Other services | 2003 |
| ST. Andrews Carpentry Contractors Limited | Manufacturing | 2004 |
| ST. George's Enabling Limited | Construction | 2004 |
| Staffing Platform Ltd | Administrative & support | 2017 |
| Stam Engineering Limited | Manufacturing | 2018 |
| Stand Tall Design and Fabrication Ltd | Manufacturing | 2007 |
| Staniland Consultancy Ltd | Professional & scientific | 2023 |
| Stanley Build Ltd | Construction | 2025 |
| Stanley Neils Limited | Wholesale & retail | 2023 |
| Starbound Gymnastics Academy LLP | | 2024 |
| Stargirl Limited | Arts & recreation | 2024 |
| Static Free Media Limited | Other services | 2015 |
| Station Twenty Ltd | Information & communication | 2024 |
| Steelhaus Laser and Powder Coating Ltd | Information & communication | 2018 |
| Steelhaus Structures Limited | Manufacturing | 2026 |
| Steer VIN Ltd | Wholesale & retail | 2025 |
| Stemaura Limited | Wholesale & retail | 2025 |
| Step and Store Limited | Manufacturing | 2010 |
| Step and Stride Clinic Limited | Wholesale & retail | 2026 |
| Stephen R. Hughes Limited | Transport & logistics | 2017 |
| Stephens Freeholds Ltd | Households | 2025 |
| Stephens Property Investments Ltd | Real estate | 2018 |
| Steribar Holdings Limited | Financial services | 2013 |
| Steribar Systems Limited | Manufacturing | 2003 |
| Sterley Limited | Information & communication | 2006 |
| Steve Cooper Construction Limited | Construction | 2002 |
| Steve Haskey Design Ltd | Professional & scientific | 2005 |
| Stewlyn Holdings Limited | Financial services | 2014 |
| Stick BOY Limited | Other services | 2024 |
| Stiley Living Limited | Wholesale & retail | 2021 |
| Stingraysoftware Ltd | Information & communication | 2026 |
| Stirling Trade Limited | Wholesale & retail | 2026 |
| Stockfield Estates Limited | Real estate | 2003 |
| Stoic Productions Limited | Arts & recreation | 2020 |
| Stoke Auto Services Limited | Wholesale & retail | 2016 |
| Stoke Road Limited | Hospitality | 2017 |
| Stokes & Hill Group Ltd | Wholesale & retail | 2025 |
| Stokes Hooper Property Limited | Real estate | 2019 |
| Stone and Earth Ltd | Construction | 2011 |
| Stone Consulting Ltd | Professional & scientific | 2008 |
| Stone Cross Plant Hire Ltd | Administrative & support | 2014 |
| Stone Cross Services (Midlands) Ltd | Construction | 2014 |
| Stone Cross Stock Holding Ltd | Financial services | 2022 |
| Stone Cross Surfacing Contractors Ltd | Construction | 2021 |
| Stone Cross Units Limited | Real estate | 2021 |
| Stone Style Cast Paving Ltd | Manufacturing | 2019 |
| Stone Worktop Specialists Ltd | Manufacturing | 2019 |
| Stop AD Limited | Professional & scientific | 2006 |
| Stork for Life Limited | Other services | 2017 |
| Storm Chai Ltd | Manufacturing | 2024 |
| Storyhaus Ltd | Information & communication | 2025 |
| Stoulton Groundcare Limited | Administrative & support | 2006 |
| Stourbridge Gymnastics Academy Ltd | Arts & recreation | 2025 |
| Stout Property Group Ltd | Real estate | 2023 |
| Stoute Group Ltd | Financial services | 2021 |
| Stow (UK) Limited | Manufacturing | 1995 |
| Strandcentre Limited | Real estate | 2024 |
| Strapzie Limited | Manufacturing | 2018 |
| Stratable Ltd | Information & communication | 2024 |
| Strategic Component Sourcing Limited | Information & communication | 2014 |
| Strategic Professionals Limited | Professional & scientific | 2012 |
| Strategic Workforce Solutions Group Limited | Administrative & support | 2013 |
| Stratejin Trade Limited | Wholesale & retail | 2026 |
| Stratus Engineering Ltd | Professional & scientific | 2024 |
| Stratus Properties Ltd | Real estate | 2015 |
| Strawberry Season Ltd | Information & communication | 2019 |
| Streetgrove Investments Limited | Construction | 2023 |
| Strength Associated Ltd | Arts & recreation | 2021 |
| Stretton Mill Limited | Households | 2019 |
| Strides Learning and Development Ltd | Administrative & support | 2013 |
| Strike FX Ltd | Manufacturing | 2020 |
| Strike Youth CIC | Education | 2023 |
| Striving for Excellence Ltd | Administrative & support | 2013 |
| Stronghold Farms Limited | Information & communication | 2016 |
| Studio 27 Holdings Limited | Professional & scientific | 2009 |
| Studio 27 Limited | Professional & scientific | 2003 |
| Studio 3 Photography Ltd | Professional & scientific | 2023 |
| Studio 46 Ltd | Extraterritorial | 2021 |
| Studio Reiss Ltd | Professional & scientific | 2024 |
| Stylish 1 Barber Ltd | Other services | 2025 |