| Slap Abbey Limited | Professional & scientific | 2015 |
| Sleepy Giant Productions Inc. Limited | Information & communication | 2018 |
| Sleepyhead Estates Limited | Real estate | 2025 |
| SLG & Sons Limited | Construction | 2006 |
| Sloanesite Ltd | Construction | 2022 |
| Slow Loris Productions Limited | Households | 2017 |
| SLV Events Ltd | Administrative & support | 2020 |
| Small Stunts Limited | Professional & scientific | 2004 |
| Smart Appliance Service Limited | Manufacturing | 2012 |
| Smart Core Solutions Ltd | Wholesale & retail | 2026 |
| Smart Property Maintenance Services LLP | | 2018 |
| Smart Seal Roofing Ltd | Construction | 2025 |
| Smart Space Garage Conversions Ltd | Construction | 2024 |
| Smart Sugar Pump Limited | Wholesale & retail | 2024 |
| Smart TEC Automation Ltd | Professional & scientific | 2024 |
| Smart Training Solutions Limited | Professional & scientific | 2011 |
| Smart Wolf Ltd | Information & communication | 2015 |
| Smartmove Property Management Ltd | Real estate | 2025 |
| Smartrak Limited | Information & communication | 2016 |
| Smiffy’S Bits Ltd | Manufacturing | 2026 |
| Smiles Childcare Ltd | Education | 2013 |
| Smiles Turkey Ltd | Health & social care | 2025 |
| Smiles Turkish Ltd | Professional & scientific | 2025 |
| Smith & Dean Homes Ltd | Real estate | 2023 |
| Smith & Fong Limited | Manufacturing | 2017 |
| Smith Brothers Brickwork Ltd | Construction | 2025 |
| Smoke and Oakum Property Ltd | Real estate | 2020 |
| Smokey J'S Pizza Ltd | Hospitality | 2024 |
| SMT Plus (Europe) Limited | Wholesale & retail | 2017 |
| Smush POP Part 2 Limited | Arts & recreation | 2022 |
| SMW Property Services Limited | Construction | 2022 |
| Snap Media Digital Ltd | Professional & scientific | 2024 |
| SNH Property Developers Limited | Real estate | 2025 |
| Snicket Films Limited | Information & communication | 2014 |
| Snipz (Hairdressing) Ltd | Other services | 2004 |
| Snjbenjamin Ltd | Health & social care | 2019 |
| Snowfield Business Services Ltd | Professional & scientific | 2011 |
| SNS Accountancy and Advisory Ltd | Professional & scientific | 2025 |
| SNS Consultants Limited | Information & communication | 2016 |
| Snub Ltd | Professional & scientific | 2008 |
| Snug AS a BUG Care Limited | Health & social care | 2025 |
| Social and Stellar Ltd | Professional & scientific | 2024 |
| Social Sticks Bromsgrove Ltd | Arts & recreation | 2024 |
| Soham Business Ltd | Wholesale & retail | 2025 |
| SOL Heating and Plumbing Limited | Construction | 2021 |
| Solarcast Trade Limited | Wholesale & retail | 2026 |
| Solarity Camper Van Conversions Ltd | Wholesale & retail | 2023 |
| Solas Collection Ltd | Administrative & support | 2019 |
| Soldato Limited | Real estate | 2018 |
| Solistay Ltd | Health & social care | 2023 |
| Sollis Solutions Ltd | Administrative & support | 2025 |
| Solo Home Delivery Ltd | Construction | 2018 |
| Somerset Properties Enterprises Ltd | Real estate | 2023 |
| Somerset Security Services Ltd | Administrative & support | 2019 |
| Somewhere Never Limited | Wholesale & retail | 2022 |
| Somnus Organic Limited | Wholesale & retail | 2024 |
| Sonic Edge Technology Limited | Information & communication | 2021 |
| Sonic Images Ultrasound Services Limited | Other services | 2023 |
| Sophia and Cinzia Limited | Information & communication | 2018 |
| Sorvean Enterprise Ltd | Wholesale & retail | 2025 |
| Soterion Estates Ltd | Real estate | 2021 |
| Soterion Holdings Ltd | Real estate | 2021 |
| Soterion Investments Ltd | Real estate | 2021 |
| Soterion Limited | Water & waste | 2009 |
| Soudini Limited | Wholesale & retail | 2011 |
| Sourceco Recruitment Fmcg Limited | Administrative & support | 2022 |
| Sourceco Recruitment Group Holdings Ltd | Financial services | 2022 |
| Sourceco Recruitment Limited | Administrative & support | 2018 |
| South Bromsgrove High Academy Trust | Education | 2013 |
| Sovereign One Ltd | Real estate | 2024 |
| Sowe Management Company Limited | Real estate | 1981 |
| SP Elite Graphics Ltd | Wholesale & retail | 2018 |
| Space - Asset Commercialisation Ltd | Wholesale & retail | 2025 |
| Spadesbourne Homes Limited | Real estate | 2023 |
| Spanclad Construction Limited | Construction | 1979 |
| Spanclad Holdings Limited | Professional & scientific | 2004 |
| Spanclad Roofing Limited | Construction | 1981 |
| Spark Automotive (Wrexham) Ltd | Wholesale & retail | 2020 |
| Spark Engineering Services Ltd | Manufacturing | 2020 |
| Sparklelynclean Ltd | Administrative & support | 2011 |
| Sparkstay Southwest Ltd | Construction | 2026 |
| Spartan Circular Ltd | Manufacturing | 2008 |
| Speedwell Films Ltd | Information & communication | 2022 |
| Speer Solutions Ltd | Construction | 2026 |
| Spektrum Interiors Ltd | Administrative & support | 2015 |
| Spencer & Co Holdings Ltd | Financial services | 2026 |
| Spencer Swinden Design Ltd | Professional & scientific | 2008 |
| Spencers Outdoor Living Ltd | Administrative & support | 2026 |
| Sperop Ltd | Wholesale & retail | 2024 |
| Sphere Sustainable Solutions Limited | Professional & scientific | 2011 |
| Spiral AI Events Limited | Professional & scientific | 2024 |
| Spire Graphics and Signs Ltd | Administrative & support | 2018 |
| Spirehouse Recruitment Limited | Administrative & support | 2023 |
| Spooky Mamas Ltd | Arts & recreation | 2022 |
| Sports and Spinal Physiotherapy Ltd | Health & social care | 2018 |
| SPR779 Ltd | Real estate | 2021 |
| Sprayology UK Limited | Construction | 2018 |
| Spraywell Paints Ltd | Manufacturing | 2024 |
| Spring Electronics Ltd | Manufacturing | 1996 |
| Spring Grove Farm Barns Limited | Hospitality | 1996 |