| DSW Group Logistics Ltd | Transport & logistics | 2022 |
| Dualpin Limited | Extraterritorial | 1994 |
| DUB Box Limited | Manufacturing | 2010 |
| Ductair Services Limited | Manufacturing | 2013 |
| Dude Food Ltd | Manufacturing | 2022 |
| Dudley Garages Limited | Administrative & support | 2008 |
| Duferco UK Limited | Wholesale & retail | 1998 |
| Duffy Property Group Ltd | Real estate | 2025 |
| Dully BOY Productions Limited | Arts & recreation | 2022 |
| Dunn Company Holdings Limited | Financial services | 2023 |
| Dunn Metals Ltd | Extraterritorial | 2017 |
| Dunns Lettings Ltd | Real estate | 2022 |
| DVC Property Developments Ltd | Real estate | 2023 |
| DW Health & Safety Holdings Limited | Financial services | 2021 |
| DW Health & Safety Limited | Health & social care | 2003 |
| DWG Contracting Services Ltd | Wholesale & retail | 2025 |
| DXD Films Ltd | Administrative & support | 2019 |
| Dynacore Limited | Wholesale & retail | 2025 |
| Dynatherm Limited | Manufacturing | 1976 |
| E & R Property Solutions Limited | Real estate | 2018 |
| E B Properties (UK) Limited | Financial services | 2018 |
| E K Newco Limited | Financial services | 2024 |
| E Webb Equestrian Limited | Arts & recreation | 2020 |
| E-Expanse Media Ltd | Professional & scientific | 2022 |
| E.Byng(Builders)Limited | Real estate | 1960 |
| E.R.C. (Properties) Limited | Real estate | 1981 |
| EA Air Handlers Ltd | Energy | 2022 |
| EA Consultancy & Management Services Ltd | Professional & scientific | 2021 |
| EAM Studio Limited | Arts & recreation | 2022 |
| East Street Pictures Limited | Information & communication | 2018 |
| Eastbourne EYE Clinic Limited | Health & social care | 2013 |
| Eastbowe Ltd | Construction | 2018 |
| Easy Truck Material Handling Limited | Manufacturing | 2009 |
| Eaton Court (Mulroy) Limited | Households | 1991 |
| Eclarity Solutions Limited | Administrative & support | 2000 |
| Eco Security Solutions Limited | Administrative & support | 2012 |
| Eco Specialists Ltd | Manufacturing | 2019 |
| Eco Wheel Motors Company Limited | Wholesale & retail | 2025 |
| Eco-Build Southwest Ltd | Construction | 2019 |
| Eco-Economix Limited | Administrative & support | 2015 |
| Ecoairbox Limited | Manufacturing | 2015 |
| Ecokit Ltd | Administrative & support | 2025 |
| Ecologics Energy Solution Ltd | Construction | 2023 |
| Ecom Cave Ltd | Wholesale & retail | 2026 |
| Ecomaware Store Ltd | Wholesale & retail | 2025 |
| Econergy Solutions Ltd | Professional & scientific | 2023 |
| Economics Tutor Ltd | Education | 2022 |
| Economics Tutoring Global Ltd | Education | 2023 |
| ED Architecture Ltd | Professional & scientific | 2013 |
| EDB Equestrian Limited | Arts & recreation | 2018 |
| EDB Show Jumping Limited | Arts & recreation | 2018 |
| Eden Clarke Property Management Ltd | Real estate | 2025 |
| Eden Stow Limited | Real estate | 2020 |
| Eden Stow Properties Limited | Real estate | 2017 |
| Edgbaston ENT (Eent) Limited | Health & social care | 2023 |
| Edington Storage Ltd | Other services | 2008 |
| Editonepost Ltd | Information & communication | 2026 |
| Edmar Consulting Limited | Professional & scientific | 2022 |
| EDR Developments Limited | Construction | 2014 |
| Educonnect Limited | Construction | 2002 |
| Edward Alain Cook Limited | Wholesale & retail | 1987 |
| Edway Developments Limited | Construction | 2020 |
| Edworks Construction Ltd | Construction | 2023 |
| EET Consulting Limited | Professional & scientific | 2016 |
| Eevil Plan Properties Limited | Real estate | 2013 |
| EGA Aviation Engineering Ltd | Professional & scientific | 2020 |
| EJ Electronics Limited | Manufacturing | 1997 |
| EK Interactive Innovations Ltd | Manufacturing | 2021 |
| Ekdance Ltd | Education | 2024 |
| EL Cube Ltd | Professional & scientific | 2024 |
| Electric Suitcase Limited | Information & communication | 2016 |
| Electric Vehicle Charging Solutions Ltd | Construction | 2022 |
| Electrikore Ltd | Construction | 2026 |
| Electro-Technik Holdings Limited | Professional & scientific | 2007 |
| Electroair Ltd | Professional & scientific | 2020 |
| Elefrela Limited | Administrative & support | 2025 |
| Element Electrical Solutions Ltd | Construction | 2024 |
| Element Real Estate Limited | Real estate | 2018 |
| Eleora Cleaners Ltd | Administrative & support | 2025 |
| Elevate Coaching Ltd | Administrative & support | 2016 |
| Elevate Merch Ltd | Wholesale & retail | 2025 |
| Elevation Studio Ltd | Information & communication | 2026 |
| Eleven a Consulting Limited | Professional & scientific | 2021 |
| Eleven Vicarage Materials Limited | Wholesale & retail | 2026 |
| Elgar Mews RTM Company Limited | Households | 2025 |
| Elgar Plumbing & Heating Limited | Other services | 2013 |
| Elgar Services Limited | Other services | 2016 |
| Elite Civil Engineers Ltd | Construction | 2021 |
| Elite Health Services Limited | Real estate | 2009 |
| Elite Landscapes Holdings Limited | Financial services | 2020 |
| Elite Racking Services Ltd | Construction | 2025 |
| Elixir Ltd | Professional & scientific | 2019 |
| Elle Rose Boutique Ltd | Wholesale & retail | 2022 |
| Ellie's Salon Ltd | Other services | 2017 |
| Ellis Construction Services Ltd | Construction | 2008 |
| Ellis Holdings & Investments (Midlands) Ltd | Financial services | 2023 |
| Ellis Music Limited | Information & communication | 2018 |
| ELM Court Flats (Walsall) Limited | Households | 1961 |
| ELM Court Flats Worcester Limited | Households | 2022 |
| Elmbridge Properties Limited | Other services | 1993 |