| Somerset Resin Bound Ltd | Construction | 2023 |
| Somerset School of Holistics Limited | Health & social care | 2018 |
| Somerset Security Solutions Limited | Administrative & support | 2025 |
| Somerset Skills & Learning CIC | Administrative & support | 2013 |
| Somerset Solutions Limited | Administrative & support | 2007 |
| Somerset Storage and Logistics Ltd | Administrative & support | 2025 |
| Somerset Sunbed Hire Limited | Other services | 2021 |
| Somerset Toilet Hire Ltd | Administrative & support | 2024 |
| Somerset Transport Ltd | Transport & logistics | 2015 |
| Somerset Viking Ltd | Wholesale & retail | 2021 |
| Somerset Wetland Wildlife Foundation Ltd | Professional & scientific | 2009 |
| Somerset Willow (Holdings) Ltd | Financial services | 2019 |
| Somerset Willow England Limited | Extraterritorial | 2016 |
| Somerset Willow Growers Limited | Agriculture & fishing | 2006 |
| Somerset Youth Theatre CIC | Arts & recreation | 2021 |
| South Point Information Management Ltd | Information & communication | 2023 |
| South West Advocates Limited | Professional & scientific | 2014 |
| South West Building Renovations Ltd | Construction | 2019 |
| South West Cleaning Services Limited | Administrative & support | 1998 |
| South West Granite and Quartz Limited | Construction | 2017 |
| South West Property Choices Limited | Real estate | 2009 |
| South West Reclamation Limited | Wholesale & retail | 2003 |
| South West Rodeo Ltd | Wholesale & retail | 2024 |
| South West Roofing Services Limited | Construction | 2024 |
| South West Testing Limited | Professional & scientific | 2023 |
| South West Trade Frames Ltd | Construction | 2022 |
| South West Wifi Ltd | Information & communication | 2021 |
| Southern Counties Animal Products Ltd | Transport & logistics | 2025 |
| Southern Engineers Limited | Manufacturing | 2008 |
| Southern Feathers Ltd | Wholesale & retail | 2025 |
| Southernwest Electrical Ltd | Construction | 2024 |
| Southgate Enterprises Holdings Limited | Financial services | 2018 |
| Southgate Enterprises Limited | Manufacturing | 2013 |
| Southgate Windows Limited | Manufacturing | 2025 |
| Southlea Management Co. Ltd | Real estate | 2021 |
| Southwest Auto Group Ltd | Wholesale & retail | 2026 |
| Southwest Consultancy Ltd | Professional & scientific | 2024 |
| Southwest Cremations Ltd | Other services | 2025 |
| Southwick Village Developments Limited | Real estate | 2021 |
| Southwwest Travel Ltd | Administrative & support | 2025 |
| Sowadiamond Ltd | Education | 2014 |
| SP HSE Services Limited | Professional & scientific | 2019 |
| Space Interiors Ltd | Construction | 2023 |
| Space LET Property Holdings Limited | Real estate | 2016 |
| Spacenet Limited | Real estate | 2012 |
| Spartan Competitions UK Ltd | Wholesale & retail | 2021 |
| Specialist Passenger Solutions Limited | Transport & logistics | 2015 |
| Spencer Muir Ltd | Construction | 2017 |
| Spenny's Sports Bar Limited | Hospitality | 2014 |
| SPG Restaurant Ltd | Hospitality | 2018 |
| Spice Club Bridgwater Limited | Hospitality | 2024 |
| Spiceworld Bridgewater Ltd | Hospitality | 2023 |
| Spin Again Limited | Information & communication | 2025 |
| SPJ Millward Limited | Construction | 2025 |
| Splashback International Limited | Extraterritorial | 1995 |
| Splatt Barn Limited | Agriculture & fishing | 2026 |
| Splatt Farm Gardens Ltd | Agriculture & fishing | 2020 |
| Splatt Growing Community C.I.C. | Agriculture & fishing | 2023 |
| Splatt Mill Ltd | Professional & scientific | 2016 |
| Sporting World Sport Services Ltd | Arts & recreation | 2007 |
| Spotlight Multimedia Group Ltd | Arts & recreation | 2025 |
| Spraytechsw Ltd | Construction | 2022 |
| Spring Farm Trustee Company Limited | Administrative & support | 2003 |
| Springway Vans Limited | Wholesale & retail | 2021 |
| Square Systems Limited | Information & communication | 1995 |
| Squires Real Estate Limited | Real estate | 2022 |
| Squirrel Campers Ltd | Wholesale & retail | 2025 |
| SRC Maintenance Services Limited | Wholesale & retail | 2009 |
| Srcmconsultant Limited | Professional & scientific | 2019 |
| SRT Integrated Security Limited | Administrative & support | 2011 |
| SRW Groundworks Ltd | Construction | 2025 |
| SSK Mobiles Ltd | Wholesale & retail | 2019 |
| Sspe Limited | Professional & scientific | 2021 |
| ST David's Equine Veterinary Practice Limited | Professional & scientific | 2018 |
| ST Marys Court (Bridgwater) Management Company Limited | Real estate | 1988 |
| Stacey's Motors Limited | Wholesale & retail | 2025 |
| Stand OUT Property Ltd | Real estate | 2026 |
| Stanton Haulage Limited | Transport & logistics | 2024 |
| Star Properties (SW) Ltd | Real estate | 2025 |
| Starkey Knight & Ford Group Ltd | Hospitality | 2026 |
| Starry Stays Ltd | Hospitality | 2023 |
| Steadfast Developments Limited | Administrative & support | 2011 |
| Steckler Limited | Administrative & support | 2012 |
| Stengun Drawings Ltd | Manufacturing | 2018 |
| Stephanie Rose Agencies Limited | Administrative & support | 2014 |
| Stephen Dunn Financial Services Ltd | Financial services | 2026 |
| Stephsam Ventures Limited | Wholesale & retail | 2025 |
| Stepping OUT in Somerset CIC | Health & social care | 2020 |
| Steps Advisory Ltd | Professional & scientific | 2019 |
| Sterling Maintenance Services Ltd | Construction | 2025 |
| Steve Payne Consultants Limited | Professional & scientific | 2018 |
| Stick IT Vinyl and Tints Limited | Professional & scientific | 2023 |
| Stickydate Limited | Hospitality | 2015 |
| STK Aesthetics Ltd | Other services | 2021 |
| Stockmoor Cafe Ltd | Hospitality | 2025 |
| Stockmoor Park Management Company Limited | Households | 2007 |
| Stoic Digital Ltd | Information & communication | 2023 |
| Stonegarth Supply Chain Services Ltd | Administrative & support | 2021 |
| Stonemore Ltd | Manufacturing | 2026 |
| Stones Farm (North Newton) Management Company Limited | Households | 2018 |