| Shift Happens Car Sales and Recovery Ltd | Wholesale & retail | 2026 |
| Shine Bright Window Cleaning Limited | Administrative & support | 2023 |
| Shire Integrated Property Holdings Limited | Real estate | 2025 |
| Shire Integrated Solutions Limited | Professional & scientific | 2007 |
| Shire Integrated Systems Limited | Construction | 1995 |
| Shirebrook Limited | Real estate | 1983 |
| Shirlstar (Holdings) Limited | Financial services | 1988 |
| Shirlstar Finance Limited | Administrative & support | 1983 |
| Shirlstar Group (Holdings) Limited | Financial services | 1999 |
| Shirlstar Overseas (Holdings) Limited | Financial services | 1999 |
| Shizam Ltd | Wholesale & retail | 2026 |
| Shoot Blue Limited | Administrative & support | 2020 |
| Shore to Shore Properties Limited | Real estate | 2017 |
| Shorebreak Group Limited | Financial services | 2024 |
| Shorebreak Property Services Limited | Construction | 2024 |
| Shortcut to Fame Ltd | Professional & scientific | 2019 |
| Shree Krishna UK Enterprises Ltd | Wholesale & retail | 2016 |
| Shree Yamuna Enterprises UK Ltd | Wholesale & retail | 2025 |
| Shreenath Enterprises UK Ltd | Wholesale & retail | 2025 |
| Shyfish Designs Limited | Other services | 2019 |
| Si-Ness Property Limited | Real estate | 2020 |
| Sidwick Holdings Limited | Hospitality | 2026 |
| Sienna-Nova Ltd | Transport & logistics | 2019 |
| Sigma Code Ltd | Information & communication | 2024 |
| Sigma Squared Solutions Limited | Wholesale & retail | 2005 |
| Signature Care Group Ltd | Public administration | 2025 |
| Signature Install Co Limited | Manufacturing | 2025 |
| Silicode Limited | Information & communication | 2016 |
| Silver Willow Ltd. | Wholesale & retail | 1998 |
| SIM Racing Machines Ltd | Manufacturing | 2020 |
| Simmons Homes Ltd | Real estate | 2025 |
| Simply Pizza Bridgwater Limited | Hospitality | 2026 |
| Single EYE Focus Films Limited | Information & communication | 2025 |
| SIP HUS Ltd | Construction | 2015 |
| Siren Industrial Limited | Construction | 2008 |
| Site Services (London) Limited | Construction | 1999 |
| Sitec Housing Limited | Extraterritorial | 2013 |
| Sitetech Solutions Ltd | Construction | 2026 |
| Sixothree Marketing Limited | Administrative & support | 2017 |
| SJA Medical Services Limited | Health & social care | 2014 |
| Skltn Events Limited | Hospitality | 2024 |
| Sky Thrills Ltd | Arts & recreation | 2025 |
| Sky View Observation Wheel Ltd | Arts & recreation | 2024 |
| Sky-Net Geomatics Ltd | Professional & scientific | 2026 |
| Skye Specialist Lettings & Management Limited | Other services | 2005 |
| SL Plastics Ltd | Water & waste | 2016 |
| SL Plastics Material Recycling Limited | Water & waste | 2024 |
| SLA on Line Sales Ltd | Wholesale & retail | 2023 |
| Slashdotdash Ltd | Information & communication | 2021 |
| SLB Investment Holdings Ltd | Financial services | 2023 |
| SLC Carpentry & Building Limited | Construction | 2018 |
| Sleep on Limited | Manufacturing | 2009 |
| Sleep Softly Limited | Wholesale & retail | 2013 |
| Slot Monkey Studios Limited | Information & communication | 2025 |
| SLS IFA Ltd | Professional & scientific | 2025 |
| SM Trading Group Limited | Wholesale & retail | 2019 |
| Small Business Accountancy Ltd | Professional & scientific | 2023 |
| Smart Build Solutions Ltd | Construction | 2018 |
| Smart Construct Solutions Ltd | Construction | 2017 |
| Smartrov Ltd | Manufacturing | 2017 |
| Smartstress Ltd | Professional & scientific | 2016 |
| SMF Freelance Ltd | Information & communication | 2024 |
| Smiles 4 U Chippenham Limited | Health & social care | 2025 |
| Smoky Plum Ltd | Hospitality | 2025 |
| Snowdrop Property Management Limited | Real estate | 2021 |
| Social Media Directions Ltd | Information & communication | 2016 |
| Socially Enterprising Ltd | Information & communication | 2025 |
| Soda & RYE Ltd | Hospitality | 2025 |
| Softerform Limited | Administrative & support | 2024 |
| Softform Limited | Administrative & support | 2018 |
| Somas Home UK Limited | Wholesale & retail | 2023 |
| Somax Consulting Ltd | Wholesale & retail | 2023 |
| Somax Finance Ltd | Information & communication | 2023 |
| Somax Group Ltd | Professional & scientific | 2023 |
| Somax Systems Ltd | Information & communication | 2025 |
| Somer Event Hire Limited | Hospitality | 2024 |
| Somerrock Festivals Limited | Administrative & support | 2024 |
| Somerrock Limited | Administrative & support | 2006 |
| Somerset Access Training Ltd | Construction | 2025 |
| Somerset Bakehouse LLP | | 2023 |
| Somerset Bar Hire Ltd | Hospitality | 2005 |
| Somerset Boat Centre Ltd | Arts & recreation | 2021 |
| Somerset Car Sales Limited | Wholesale & retail | 1991 |
| Somerset Carpenters Limited | Construction | 1997 |
| Somerset Carpet Care Ltd | Administrative & support | 2019 |
| Somerset Cider Vinegar Company Limited | Manufacturing | 2004 |
| Somerset Film and Video Ltd | Information & communication | 1997 |
| Somerset Finance Department Ltd | Professional & scientific | 2024 |
| Somerset Heat Pump & Solar Ltd | Construction | 2026 |
| Somerset Home Surveys Ltd | Professional & scientific | 2016 |
| Somerset Investments Limited | Real estate | 2009 |
| Somerset Joinery Solutions Ltd | Manufacturing | 2021 |
| Somerset Laundry Services Limited | Other services | 2014 |
| Somerset Minibus Hire Limited | Transport & logistics | 2021 |
| Somerset Motor Services Ltd | Wholesale & retail | 2025 |
| Somerset Plant Training Ltd | Construction | 2024 |
| Somerset Property Holiday Letting Limited | Hospitality | 2022 |
| Somerset Pubs (South) Ltd | Hospitality | 2025 |
| Somerset Pubs Management Ltd | Hospitality | 2023 |
| Somerset Residents Association Limited | Extraterritorial | 2024 |