| Saltus Fidei Ltd | Wholesale & retail | 2026 |
| SAM Allardyce Investments Limited | Administrative & support | 2012 |
| SAM Allardyce Limited | Arts & recreation | 2003 |
| SAM Cooper's Rightstyle Ltd | Wholesale & retail | 2022 |
| SAM Douglas Education Limited | Education | 2026 |
| SAM Fawcett Ltd | Wholesale & retail | 2023 |
| SAM Hulme Creative Limited | Professional & scientific | 2024 |
| SAM Interior Services Ltd | Other services | 2026 |
| SAM IT Support Ltd | Information & communication | 2020 |
| SAM Logan Limited | Other services | 2011 |
| SAM Property Management Limited | Real estate | 2023 |
| SAM Tech Bolton Ltd | Wholesale & retail | 2023 |
| SAM Witter Personal Training Ltd | Arts & recreation | 2015 |
| Sam's Clothing Ltd | Wholesale & retail | 2025 |
| Samb Properties Ltd | Real estate | 2024 |
| Sambic Investment and Properties Ltd | Real estate | 2025 |
| Sambic Kitchen Ltd | Hospitality | 2025 |
| Sambic Online Store Limited | Wholesale & retail | 2025 |
| Samco Creations Ltd | Wholesale & retail | 2025 |
| Samdofi Health Care Ltd | Administrative & support | 2017 |
| Same Again Pubs Limited | Hospitality | 2017 |
| Same Day Shippers Ltd | Transport & logistics | 2026 |
| Sameday Solutions (Logistics) Limited | | 2010 |
| Sameed Tech Ltd | Wholesale & retail | 2023 |
| Sami Arch Designs Limited | Professional & scientific | 2023 |
| Sami Fried Chicken Ltd | Hospitality | 2023 |
| Sami Mini Market Limited | Wholesale & retail | 2019 |
| Samijand Ltd | Hospitality | 2025 |
| Samin Recruitment Ltd | Administrative & support | 2025 |
| Samira Ltd | Health & social care | 2021 |
| Samosa Shack Limited | Hospitality | 2016 |
| Samot Global Resources Ltd | Transport & logistics | 2023 |
| Samoutsource Ltd | Administrative & support | 2025 |
| Sampson VA Services Ltd | Administrative & support | 2025 |
| Samray Ltd | Real estate | 2020 |
| Samsaa Ltd | Health & social care | 2018 |
| Samu Properties Ltd | Real estate | 2024 |
| Samuel Thistlethwaite Business Analysis Limited | Information & communication | 2023 |
| Samza Trading Limited | Wholesale & retail | 2023 |
| SAN Local Express Ltd | Wholesale & retail | 2025 |
| SAN Pharmaceuticals Limited | Administrative & support | 2025 |
| Sana Clothing Services Limited | Manufacturing | 2025 |
| Sana Taimur Ltd | Public administration | 2022 |
| Sana Travel Services Ltd | Administrative & support | 2016 |
| Sanad Capital Ltd | Real estate | 2025 |
| Sanah Haider Optom Ltd | Health & social care | 2023 |
| Sanar Pharm Ltd | Health & social care | 2023 |
| Sanas Transport & Exports Ltd | Wholesale & retail | 2014 |
| Sanat Concept Limited | Real estate | 2024 |
| Sanat Shah Limited | Real estate | 2009 |
| Sanat Shah Orthopaedics Limited | Health & social care | 2021 |
| Sanber LAB Services Limited | Financial services | 2023 |
| Sanber Limited | Construction | 2001 |
| Sanco Logistics Limited | Transport & logistics | 2025 |
| Sanctuary Tattoo Ltd | Other services | 2023 |
| Sandalwood Properties Limited | Real estate | 2021 |
| Sandbrook Beverages Ltd | Hospitality | 2019 |
| Sandefjord Ltd | Hospitality | 2020 |
| Sandeluxe MAN Limited | Wholesale & retail | 2025 |
| Sanderson Capital Partners Limited | Financial services | 2012 |
| Sandham Build Ltd | Construction | 2025 |
| Sandhof Limited | Real estate | 1991 |
| Sandifords Retail Limited | Wholesale & retail | 2017 |
| Sandown Holdings Limited | Professional & scientific | 2011 |
| Sandown Homes Limited | Real estate | 1993 |
| Sandra Dalli Prai Ltd | Information & communication | 2016 |
| Sandra Hartley Limited | Health & social care | 2017 |
| Sandra Rosa & Co Solicitors Ltd | Professional & scientific | 2023 |
| Sanghani Holding Ltd | Real estate | 2019 |
| Sanghani Ltd | Real estate | 2025 |
| Sangra Transport MCR Limited | Transport & logistics | 2022 |
| Sanian Limited | Information & communication | 2014 |
| Sankey Heating & Plumbing Supplies Ltd | Wholesale & retail | 2006 |
| Sankey-Kearns Limited | Administrative & support | 2016 |
| Sanluca Development Limited | Administrative & support | 2014 |
| Sanson Foods Ltd | Manufacturing | 2020 |
| Sanson Holdings Ltd | Financial services | 2022 |
| Sansovino Developments Limited | Agriculture & fishing | 2019 |
| Sansupplies Limited | Wholesale & retail | 2024 |
| Sant Systems Ltd | Construction | 2014 |
| Santex Limited | Wholesale & retail | 2019 |
| Santora Investment Limited | Wholesale & retail | 2025 |
| Sanya Pharm Ltd | Health & social care | 2023 |
| SAP Properties Ltd | Real estate | 2025 |
| SAP15 UK Limited | Wholesale & retail | 2018 |
| Sapere Digital Ltd | Information & communication | 2026 |
| Saphire Properties Ltd | Real estate | 2021 |
| Sapling Innovation Ltd | Wholesale & retail | 2020 |
| Sapling Leisure Limited | Hospitality | 2025 |
| Sapphire Vehicle Rentals Limited | Administrative & support | 2017 |
| SAQ Pharma Limited | Health & social care | 2023 |
| Saqar Ltd | Wholesale & retail | 2023 |
| SAR Accountants Ltd | Professional & scientific | 2023 |
| SAR Engineering Ltd | Professional & scientific | 2026 |
| SAR Prime Properties Ltd | Real estate | 2026 |
| SAR Travel Ltd | Transport & logistics | 2021 |
| Sara DM Enterprises Ltd. | Wholesale & retail | 2013 |
| Saracen Leather Furniture Ltd. | Manufacturing | 1996 |
| Saraco Industries Holdings Limited | Financial services | 2020 |
| Saraco Industries Limited | Manufacturing | 2005 |