| Safeguarding Today Online Limited | Education | 2023 |
| Safeguarding Union Limited | Education | 2026 |
| Safehouses Fostering Limited | Administrative & support | 2000 |
| Safehouses Limited | Health & social care | 1997 |
| Safepath Property Group Ltd | Real estate | 2025 |
| Saferise Scaffolding Solutions Limited | Construction | 2024 |
| Safeside Construction Limited | Construction | 2025 |
| Safeside Logistics Limited | Transport & logistics | 2025 |
| Safeside Security Limited | Administrative & support | 2022 |
| Safeside Services Limited | Other services | 2025 |
| Safetech Innovation Limited | Wholesale & retail | 2021 |
| Safety Awareness Limited | Administrative & support | 1997 |
| Safety Healthcare Service Ltd | Other services | 2024 |
| Safety Innovation Development - World Wide Wonders - United Kingdom Limited | Information & communication | 2025 |
| Safety IS Everybody's Business Ltd | Professional & scientific | 2023 |
| Safevalue Services Limited | Wholesale & retail | 1994 |
| Safewaters Direct UK Ltd | Wholesale & retail | 2026 |
| Saffrondelta Ltd | Wholesale & retail | 2019 |
| Safiyas Beauty Therapy Bolton Ltd | Other services | 2016 |
| Safr Sojara Ltd | Real estate | 2025 |
| Safraz Patel Limited | Administrative & support | 2025 |
| Safta (PVT) Ltd | Wholesale & retail | 2026 |
| Safta Limited | Wholesale & retail | 2016 |
| Sagem Investment Limited | Real estate | 2025 |
| Saghi Limited | Extraterritorial | 2020 |
| Saghir Services Ltd | Administrative & support | 2023 |
| Sagya Ltd | Wholesale & retail | 2021 |
| SAH Discount Store Ltd | Wholesale & retail | 2025 |
| SAH Shelfco Limited | Information & communication | 2024 |
| Saha Catering Ltd | Hospitality | 2023 |
| Sahajanand Investments Ltd | Real estate | 2015 |
| Sahak Travel Ltd | Administrative & support | 2025 |
| Sahamson Builders Ltd | Extraterritorial | 2018 |
| Sahand & Souziar Ltd | Real estate | 2022 |
| Sahar Pharm Ltd | Administrative & support | 2022 |
| Sahaya Trending Limited | Wholesale & retail | 2022 |
| Sahi Global Services Limited | Transport & logistics | 2020 |
| Sahil Telecom Ltd | Wholesale & retail | 2025 |
| Sahl International Ltd | Manufacturing | 2000 |
| Sahm Medics Ltd | Health & social care | 2023 |
| Sahse Ltd | Construction | 2026 |
| SAI Food Bolton Ltd | Hospitality | 2017 |
| SAI Spice Limited | Hospitality | 2012 |
| Saim Fashion Ltd | Wholesale & retail | 2023 |
| Saimaa Property Limited | Extraterritorial | 2016 |
| Saint Wooden Flooring Limited | Construction | 2001 |
| Saints Champs Limited | Other services | 2022 |
| Sainttbourg Ltd | Wholesale & retail | 2024 |
| Saipen Ltd | Other services | 2022 |
| Saira Ltd | Wholesale & retail | 2024 |
| Sairaf Ltd | Wholesale & retail | 2026 |
| Sairajs Enterprises Ltd | Real estate | 2025 |
| Sajd 2504 Ltd | Wholesale & retail | 2026 |
| Sajibul Company Ltd | Wholesale & retail | 2020 |
| Sajmo Cosmetics Ltd | Wholesale & retail | 2025 |
| Sajoto Limited | Arts & recreation | 2019 |
| Sakah Limited | Information & communication | 2018 |
| Sake Sushi Ltd | Hospitality | 2019 |
| Sakinas Healthcare Limited | Health & social care | 2016 |
| Sakisha Group Ltd | Professional & scientific | 2021 |
| Sakisha Limited | Administrative & support | 2020 |
| Sakmusic Ltd | Arts & recreation | 2022 |
| Saks Holdings Ltd | Real estate | 2015 |
| Saks Investments Ltd | Real estate | 2015 |
| Saks Wigan Ltd | Real estate | 2026 |
| SAL Creative Limited | Information & communication | 2026 |
| Sala Thai Spa Limited | Other services | 2025 |
| Salaam Asia Stores Ltd | Wholesale & retail | 2019 |
| Salaar E-Com Limited | Wholesale & retail | 2024 |
| Salaarz Limited | Wholesale & retail | 2022 |
| Saladishy Limited | Wholesale & retail | 2018 |
| Salahadeen Shawarma Ltd | Hospitality | 2024 |
| Salahuddin Trading Company Ltd | Wholesale & retail | 2025 |
| Salam & Co Consultants Ltd | Administrative & support | 2014 |
| Salamanda Media Ltd | Information & communication | 2020 |
| Salamander Property Limited | Real estate | 2023 |
| Salarlink Ltd | Wholesale & retail | 2024 |
| Salcroft Global Ltd | Wholesale & retail | 2023 |
| Salcroft International Ltd | Wholesale & retail | 2021 |
| Saledrive AI Ltd | Wholesale & retail | 2025 |
| Sales & Strategy Ltd. | Professional & scientific | 2018 |
| Sales at Personal Care Limited | Wholesale & retail | 2016 |
| Sales Geek AMZ Ltd | Professional & scientific | 2021 |
| Salescorner Ltd | Wholesale & retail | 2025 |
| Salesrific Limited | Professional & scientific | 2023 |
| Salford City Football Club Limited | Arts & recreation | 2014 |
| Salford Excavations Construction Limited | Water & waste | 2014 |
| Salim Patel Limited | Wholesale & retail | 2015 |
| Salisbury Construction Limited | Construction | 2015 |
| Salitter Consulting Limited | Professional & scientific | 2018 |
| Salixra Ltd | Health & social care | 2026 |
| Salmed Services Ltd | Health & social care | 2021 |
| Salmons (Caterers) Limited | Hospitality | 1957 |
| Salon and Sisters Ltd | Wholesale & retail | 2022 |
| Salon Eleven Bolton Ltd | Other services | 2021 |
| Salt (Bolton) Ltd | Hospitality | 2024 |
| Salt Gems Ltd | Wholesale & retail | 2017 |
| Salt K Limited | Construction | 2021 |
| Saltech One Limited | Wholesale & retail | 2018 |
| Saltersford Gardens Management Company Limited | Households | 2018 |