| Star Mobile & Parts Ltd. | Wholesale & retail | 2016 |
| Starbuck PUB Company Ltd | Hospitality | 2024 |
| Starclean Blackpool Services Ltd | Administrative & support | 2019 |
| Starcleanz Ltd | Administrative & support | 2026 |
| Starfish Lodge Ltd | Hospitality | 2026 |
| Staroto Ucheliste Ltd | Information & communication | 2019 |
| Starr Gate Tanning Ltd | Other services | 2025 |
| Stars Pizza Milano Ltd | Hospitality | 2021 |
| Starz Fusion Ltd | Arts & recreation | 2026 |
| Station Yard Garage Limited | Wholesale & retail | 2003 |
| Statsquo Ltd | Information & communication | 2019 |
| Status Assets UK Ltd | Hospitality | 2012 |
| Stavely Developments Limited | Construction | 2020 |
| Stay Blackpool 190 Limited | Hospitality | 2021 |
| Stay Warm Energy (UK) Ltd | Construction | 2017 |
| Stay-Fit Forget Routine Workouts Ltd | Information & communication | 2014 |
| Stayblackpool Community Interest Company | Hospitality | 1947 |
| Stayinginn Limited | Hospitality | 2025 |
| Staynest Properties Limited | Real estate | 2025 |
| Stays in Blackpool Ltd | Hospitality | 2023 |
| Steadfast Scaffolding Services Ltd | Construction | 2022 |
| Steamy Windows Limited | Construction | 2009 |
| Steel Appeal Workshop Limited | Manufacturing | 2000 |
| Steel Connections (NW) Ltd | Professional & scientific | 2019 |
| Steel Loches Ltd | Wholesale & retail | 2025 |
| Steelwind Dynamics Ltd | Professional & scientific | 2025 |
| Steep Gravity Limited | Information & communication | 2014 |
| Stefanispizzeria Limited | Hospitality | 2017 |
| Stelfox Electrical Solutions Ltd | Construction | 2025 |
| Stellar Incorperated Limited | Administrative & support | 2024 |
| Stellar UK Properties Ltd | Real estate | 2020 |
| Stemsphere Education Ltd | Education | 2024 |
| STEP9 Consulting Limited | Information & communication | 2014 |
| Stephen Mangham Marketing Consultancy Ltd | Professional & scientific | 2019 |
| Stephen Mclaughlin Golf Ltd | Wholesale & retail | 2025 |
| Stephens Malthouse Ltd | Wholesale & retail | 2025 |
| Stephensons Property Limited | Real estate | 2016 |
| Sterich Maintenance and Construction Limited | Construction | 1998 |
| Steve Dickinson and Co.Electrical Services Limited | Other services | 2002 |
| Steve Hastings Drain Services Limited | Water & waste | 2008 |
| Steve Hawley Plastering Ltd | Construction | 2025 |
| Steve Lynn Building Contractors Limited | Construction | 2009 |
| Steve Taylor Haulage Ltd | Transport & logistics | 2012 |
| Steve Walsh Safety Solutions Ltd | Professional & scientific | 2025 |
| Stevens Lettings Ltd | Real estate | 2025 |
| Stew B Electrical Ltd | Manufacturing | 2018 |
| Stewart Dick IT Services Ltd | Information & communication | 2017 |
| Stewco Limited | Hospitality | 2012 |
| STEWCO2 Limited | Education | 2023 |
| Stingray Solutions Ltd | Information & communication | 2019 |
| Stirling Claims Solutions Ltd | Financial services | 2025 |
| Stirling Film and TV Production Ltd | Wholesale & retail | 2025 |
| Stirling Point Limited | Real estate | 2019 |
| Stock Properties North West Limited | Real estate | 2023 |
| Stockghyll Management Limited | Households | 1991 |
| Stone House Hotel Blackpool Ltd | Hospitality | 2019 |
| Stone Jetty Professional Limited | Professional & scientific | 2015 |
| Stone Key Investments Ltd | Real estate | 2020 |
| Stone SET Northwest Ltd | Administrative & support | 2023 |
| Stonecroft Developments Limited | Construction | 1988 |
| Stoneygate 48 Limited | Administrative & support | 2002 |
| Stop Cybercrime Ltd | Information & communication | 2019 |
| Stopandnibble Ltd | Hospitality | 2025 |
| Stopped Clock Holdings Ltd | Financial services | 2021 |
| Storage Solutions (Thornton Cleveleys) Ltd | Administrative & support | 2016 |
| Storage Solutions 4U Ltd | Transport & logistics | 2025 |
| Stormfix Roofing Ltd | Construction | 2023 |
| Storrs Park Management Company Limited | Households | 1993 |
| Storton Property Limited | Real estate | 2023 |
| Stove Industry Supplies Limited | Wholesale & retail | 2014 |
| Stpkp Estates Limited | Real estate | 2025 |
| STR Plumbing Ltd | Construction | 2025 |
| Strachan Travel Limited | Administrative & support | 1983 |
| Straight a Films Ltd | Information & communication | 2024 |
| Stranmillis Ltd | Wholesale & retail | 2025 |
| Strategic Partnering (Global) Ltd | Professional & scientific | 2021 |
| Strategy Consultation Limited | Information & communication | 2017 |
| Strategy Leadership and Transformation Consulting Ltd | Information & communication | 2017 |
| Stratford Lingley Ltd | Wholesale & retail | 2025 |
| Streamside East Ltd | Wholesale & retail | 2025 |
| Street Proof Ltd | Professional & scientific | 2026 |
| Street to Shelter Limited | Real estate | 2025 |
| Streetwise Legal Limited | Professional & scientific | 2016 |
| Strevalls Ltd | Information & communication | 2017 |
| Stringermusicpublishing Limited | Information & communication | 2021 |
| Strompf Properties Ltd | Real estate | 2014 |
| Strompf Sales Ltd | Wholesale & retail | 2019 |
| Strong Football Community C.I.C. | Health & social care | 2024 |
| STT Yachting Limited | Extraterritorial | 2022 |
| Stuart Doyle UK Limited | Construction | 2020 |
| Stuart Hotel Blackpool Limited | Hospitality | 2025 |
| Stuart Lockwood Plumbing & Heating Limited | Construction | 1998 |
| Stuart Lowe Roofing & Co. Limited | Construction | 2018 |
| Studio 36 Digital Limited | Professional & scientific | 2020 |
| Studio Luxe Beauty Ltd | Other services | 2025 |
| Studio Nails ST Annes Ltd | Other services | 2025 |
| Studio Towers Limited | Information & communication | 2017 |
| Stuff IT Ltd | Manufacturing | 2011 |
| SUB (Market Street) Limited | Hospitality | 2022 |
| SUB Rosa International Limited | Administrative & support | 2021 |